| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cutting Edge |
B Pathway1
* Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322;
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109; and
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390
Secreted prokaryotic effector proteins have evolved to modulate
the cellular functions of specific eukaryotic hosts. Generally, these
proteins are considered virulence factors that facilitate parasitism.
However, in certain plant and insect eukaryotic/prokaryotic
relationships, effector proteins are involved in the establishment of
commensal or symbiotic interactions. In this study, we report that the
AvrA protein from Salmonella typhimurium, a common
enteropathogen of humans, is an effector molecule that inhibits
activation of the key proinflammatory NF-
B transcription factor and
augments apoptosis in human epithelial cells. This activity is
similar but mechanistically distinct from that described for YopJ, an
AvrA homolog expressed by the bacterial pathogen
Yersinia. We suggest that AvrA may limit virulence in
vertebrates in a manner analogous to avirulence factors in plants, and
as such, is the first bacterial effector from a mammalian pathogen that
has been ascribed such a function.
This article has been cited by other articles:
|
|
 |
|
  G. O. Canny and B. A. McCormick Bacteria in the Intestine, Helpful Residents or Enemies from Within? Infect. Immun., August 1, 2008; 76(8): 3360 - 3373. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Le Negrate, B. Faustin, K. Welsh, M. Loeffler, M. Krajewska, P. Hasegawa, S. Mukherjee, K. Orth, S. Krajewski, A. Godzik, et al. Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF-{kappa}B, Suppresses I{kappa}B{alpha} Ubiquitination and Modulates Innate Immune Responses J. Immunol., April 1, 2008; 180(7): 5045 - 5056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Billips, S. G. Forrestal, M. T. Rycyk, J. R. Johnson, D. J. Klumpp, and A. J. Schaeffer Modulation of Host Innate Immune Response in the Bladder by Uropathogenic Escherichia coli Infect. Immun., November 1, 2007; 75(11): 5353 - 5360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Ye, E. O. Petrof, D. Boone, E. C. Claud, and J. Sun Salmonella Effector AvrA Regulation of Colonic Epithelial Cell Inflammation by Deubiquitination Am. J. Pathol., September 1, 2007; 171(3): 882 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Giacomodonato, S. Uzzau, D. Bacciu, R. Caccuri, S. H. Sarnacki, S. Rubino, and M. C. Cerquetti SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium are synthesized at late stages of infection in mice Microbiology, April 1, 2007; 153(4): 1221 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. de Oliveira-Marques, L. Cyrne, H. S. Marinho, and F. Antunes A Quantitative Study of NF-{kappa}B Activation by H2O2: Relevance in Inflammation and Synergy with TNF-{alpha} J. Immunol., March 15, 2007; 178(6): 3893 - 3902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rytkonen, J. Poh, J. Garmendia, C. Boyle, A. Thompson, M. Liu, P. Freemont, J. C. D. Hinton, and D. W. Holden SseL, a Salmonella deubiquitinase required for macrophage killing and virulence PNAS, February 27, 2007; 104(9): 3502 - 3507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Neish TLRS in the Gut. II. Flagellin-induced inflammation and antiapoptosis Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G462 - G466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mittal, S.-Y. Peak-Chew, and H. T. McMahon Acetylation of MEK2 and I{kappa}B kinase (IKK) activation loop residues by YopJ inhibits signaling PNAS, December 5, 2006; 103(49): 18574 - 18579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vijay-Kumar, H. Wu, R. Jones, G. Grant, B. Babbin, T. P. King, D. Kelly, A. T. Gewirtz, and A. S. Neish Flagellin Suppresses Epithelial Apoptosis and Limits Disease during Enteric Infection Am. J. Pathol., November 1, 2006; 169(5): 1686 - 1700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Fehr, C. Casanova, A. Liverman, H. Blazkova, K. Orth, D. Dobbelaere, J. Frey, and S. E. Burr AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-{kappa}B signalling pathway. Microbiology, September 1, 2006; 152(Pt 9): 2809 - 2818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sharma, S. Tesfay, F. L. Tomson, R. P. Kanteti, V. K. Viswanathan, and G. Hecht Balance of bacterial pro- and anti-inflammatory mediators dictates net effect of enteropathogenic Escherichia coli on intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, April 1, 2006; 290(4): G685 - G694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-T. Tien, S. E. Girardin, B. Regnault, L. Le Bourhis, M.-A. Dillies, J.-Y. Coppee, R. Bourdet-Sicard, P. J. Sansonetti, and T. Pedron Anti-Inflammatory Effect of Lactobacillus casei on Shigella-Infected Human Intestinal Epithelial Cells J. Immunol., January 15, 2006; 176(2): 1228 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Newman, P. Salunkhe, A. Godzik, and J. C. Reed Identification and Characterization of a Novel Bacterial Virulence Factor That Shares Homology with Mammalian Toll/Interleukin-1 Receptor Family Proteins Infect. Immun., January 1, 2006; 74(1): 594 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zeng, H. Wu, V. Sloane, R. Jones, Y. Yu, P. Lin, A. T. Gewirtz, and A. S. Neish Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G96 - G108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Creuzburg, J. Recktenwald, V. Kuhle, S. Herold, M. Hensel, and H. Schmidt The Shiga Toxin 1-Converting Bacteriophage BP-4795 Encodes an NleA-Like Type III Effector Protein J. Bacteriol., December 15, 2005; 187(24): 8494 - 8498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Troisfontaines and G. R. Cornelis Type III Secretion: More Systems Than You Think Physiology, October 1, 2005; 20(5): 326 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Geddes, M. Worley, G. Niemann, and F. Heffron Identification of New Secreted Effectors in Salmonella enterica Serovar Typhimurium Infect. Immun., October 1, 2005; 73(10): 6260 - 6271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Hunstad, S. S. Justice, C. S. Hung, S. R. Lauer, and S. J. Hultgren Suppression of Bladder Epithelial Cytokine Responses by Uropathogenic Escherichia coli Infect. Immun., July 1, 2005; 73(7): 3999 - 4006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, M. E. Hobert, Y. Duan, A. S. Rao, T.-C. He, E. B. Chang, and J. L. Madara Crosstalk between NF-{kappa}B and {beta}-catenin pathways in bacterial-colonized intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, July 1, 2005; 289(1): G129 - G137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Knodler, B. B. Finlay, and O. Steele-Mortimer The Salmonella Effector Protein SopB Protects Epithelial Cells from Apoptosis by Sustained Activation of Akt J. Biol. Chem., March 11, 2005; 280(10): 9058 - 9064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hapfelmeier, B. Stecher, M. Barthel, M. Kremer, A. J. Muller, M. Heikenwalder, T. Stallmach, M. Hensel, K. Pfeffer, S. Akira, et al. The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms J. Immunol., February 1, 2005; 174(3): 1675 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Trosky, S. Mukherjee, D. L. Burdette, M. Roberts, L. McCarter, R. M. Siegel, and K. Orth Inhibition of MAPK Signaling Pathways by VopA from Vibrio parahaemolyticus J. Biol. Chem., December 10, 2004; 279(50): 51953 - 51957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, M. E. Hobert, A. S. Rao, A. S. Neish, and J. L. Madara Bacterial activation of {beta}-catenin signaling in human epithelia Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G220 - G227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Lin, P. O. Simon Jr., A. T. Gewirtz, A. S. Neish, A. J. Ouellette, J. L. Madara, and W. I. Lencer Paneth Cell Cryptdins Act in Vitro as Apical Paracrine Regulators of the Innate Inflammatory Response J. Biol. Chem., May 7, 2004; 279(19): 19902 - 19907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Haraga and S. I. Miller A Salmonella enterica Serovar Typhimurium Translocated Leucine-Rich Repeat Effector Protein Inhibits NF-{kappa}B-Dependent Gene Expression Infect. Immun., July 1, 2003; 71(7): 4052 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yoon, Z. Liu, Y. Eyobo, and K. Orth Yersinia Effector YopJ Inhibits Yeast MAPK Signaling Pathways by an Evolutionarily Conserved Mechanism J. Biol. Chem., January 17, 2003; 278(4): 2131 - 2135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chan, S. Baker, C. C. Kim, C. S. Detweiler, G. Dougan, and S. Falkow Genomic Comparison of Salmonella enterica Serovars and Salmonella bongori by Use of an S. enterica Serovar Typhimurium DNA Microarray J. Bacteriol., January 15, 2003; 185(2): 553 - 563. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
