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The Journal of Immunology, 2002, 169: 2842-2845.
Copyright © 2002 by The American Association of Immunologists

Cutting Edge

Cutting Edge: Thymocyte-Independent and Thymocyte-Dependent Phases of Epithelial Patterning in the Fetal Thymus1

David B. Klug2,3, Carla Carter3, Irma B. Gimenez-Conti and Ellen R. Richie4

Department of Carcinogenesis, University of Texas, M. D. Anderson Cancer Center, Smithville, TX 78957

Thymic epithelial cells (TECs) in adult mice have been classified into distinct subsets based on keratin expression profiles. To explore the emergence of TEC subsets during ontogeny, we analyzed keratin 8 and keratin 5 expression at several stages of fetal development in normal C57BL/6J mice. In addition, thymic epithelial development and compartmentalization were explored in recombination-activating gene 2/common cytokine receptor {gamma}-chain-deficient and Ikaros-null mice that sustain early and profound blocks in thymocyte differentiation. The results demonstrate that initial patterning of the thymic epithelial compartment as defined by differential keratin expression does not depend on inductive signals from hematopoietic cells. However, thymocyte-derived signals are required during late fetal stages for continued development and maintenance of TEC subsets in the neonate and adult.




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