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Cutting Edge |
Department of Carcinogenesis, University of Texas, M. D. Anderson Cancer Center, Smithville, TX 78957
Thymic epithelial cells (TECs) in adult mice have been
classified into distinct subsets based on keratin expression profiles.
To explore the emergence of TEC subsets during ontogeny, we analyzed
keratin 8 and keratin 5 expression at several stages of fetal
development in normal C57BL/6J mice. In addition, thymic epithelial
development and compartmentalization were explored in
recombination-activating gene 2/common cytokine receptor
-chain-deficient and Ikaros-null mice that sustain early and
profound blocks in thymocyte differentiation. The results demonstrate
that initial patterning of the thymic epithelial compartment as defined
by differential keratin expression does not depend on inductive signals
from hematopoietic cells. However, thymocyte-derived signals are
required during late fetal stages for continued development and
maintenance of TEC subsets in the neonate and
adult.
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