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* Graduate Group in Immunology and
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104
NK T cells are a lymphocyte lineage that is selected by CD1d and is
characterized by the ability to rapidly secrete large amounts of both
IFN-
and IL-4 after TCR stimulation. Using reactivity to CD1d
tetramers to define presumptive NK T cells, several NK T cell
progenitor populations were characterized based upon NK marker
expression and CD4 vs CD8 expression. The earliest populations were
found to be negative for NK markers and could proliferate to IL-7,
while mature NK T cells did not. The NK1.1- NK T cell
progenitors were capable of up-regulating NK1.1 when transferred in
vivo. Upon stimulation, the NK1.1- populations secrete
IL-4, but little IFN-. As the cells mature and up-regulate NK1.1,
they acquire the ability to secrete IFN-. Finally, the Tec family
tyrosine kinase Itk is necessary for optimal NK1.1 up-regulation and
hence final maturation of NK T cells. The
itk-/- mice also display a
progressive decrease in NK T cells in older animals, suggesting a
further role in peripheral maintenance.
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