The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Christiansen, S. C.
Right arrow Articles by Zuraw, B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Christiansen, S. C.
Right arrow Articles by Zuraw, B. L.
The Journal of Immunology, 2002, 169: 2054-2060.
Copyright © 2002 by The American Association of Immunologists

Up-Regulation of Functional Kinin B1 Receptors in Allergic Airway Inflammation1

Sandra C. Christiansen*, Jane Eddleston*, Katharine M. Woessner*, Sandra S. Chambers*, Richard Ye{dagger}, Zhixing K. Pan* and Bruce L. Zuraw2,*

* Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037; and {dagger} Department of Pharmacology, University of Illinois, Chicago, IL 60612

B1 receptors are known to be induced during allergic airway inflammation in animal models. However, little is known regarding in vivo B1 receptor expression in humans. We examined B1 receptor mRNA expression in nasal tissue samples from allergic rhinitis and normal subjects. Allergic rhinitis subjects displayed significantly higher expression of B1 receptor mRNA than did the normal subjects, and nasal allergen challenge increased B1 receptor mRNA expression at 8 to 24 h time points in allergic rhinitis subjects. No significant difference was found in B2 receptor expression. To confirm B2 and B1 receptor functional activity, subjects were challenged with kinin agonists. Nasal challenge with the B1 receptor ligand, Lys-des-Arg-bradykinin (BK), activated extracellular signal-regulated kinase in allergic rhinitis, but not normal, subjects. Nasal challenge with the B2 receptor ligand, BK, activated extracellular signal-regulated kinase in both allergic rhinitis and normal subjects. The consequences of B1 receptor activation were investigated using the human airway epithelial cell lines A549 and BEAS-2B. We demonstrated that Lys-des-Arg-BK activates the transcription factor AP-1. Taken together, these results show that functional B1 receptors are induced in the airway during allergic inflammation and suggest that they participate in the regulation of gene expression.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. Liu, A. M. Freyer, and I. P. Hall
Bradykinin activates calcium-dependent potassium channels in cultured human airway smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L898 - L907.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
F. G. Pelorosso, A. V. Halperin, A. M. Palma, W. Nowak, A. E. Errasti, and R. P. Rothlin
Neutral Endopeptidase Up-Regulation in Isolated Human Umbilical Artery: Involvement in Desensitization of Bradykinin-Induced Vasoconstrictor Effects
J. Pharmacol. Exp. Ther., February 1, 2007; 320(2): 713 - 720.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. H. Bengtson, S. B. Phagoo, A. Norrby-Teglund, L. Pahlman, M. Morgelin, B. L. Zuraw, L. M. F. Leeb-Lundberg, and H. Herwald
Kinin receptor expression during Staphylococcus aureus infection
Blood, September 15, 2006; 108(6): 2055 - 2063.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J.-P. Fortin, L. Gera, J. Bouthillier, J. M. Stewart, A. Adam, and F. Marceau
Endogenous Aminopeptidase N Decreases the Potency of Peptide Agonists and Antagonists of the Kinin B1 Receptors in the Rabbit Aorta
J. Pharmacol. Exp. Ther., September 1, 2005; 314(3): 1169 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. L.M. Cruden, G. H. Tse, K. A.A. Fox, C. A. Ludlam, I. Megson, and D. E. Newby
B1 Kinin Receptor Does Not Contribute to Vascular Tone or Tissue Plasminogen Activator Release in the Peripheral Circulation of Patients With Heart Failure
Arterioscler. Thromb. Vasc. Biol., April 1, 2005; 25(4): 772 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. M. F. Leeb-Lundberg, F. Marceau, W. Muller-Esterl, D. J. Pettibone, and B. L. Zuraw
International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences
Pharmacol. Rev., March 1, 2005; 57(1): 27 - 77.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
G. Morissette, J.-P. Fortin, S. Otis, J. Bouthillier, and F. Marceau
A Novel Nonpeptide Antagonist of the Kinin B1 Receptor: Effects at the Rabbit Receptor
J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1121 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. E. Ramos-Nino, L. Scapoli, M. Martinelli, S. Land, and B. T. Mossman
Microarray Analysis and RNA Silencing Link fra-1 to cd44 and c-met Expression in Mesothelioma
Cancer Res., July 1, 2003; 63(13): 3539 - 3545.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.