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Differential Expression of the Inhibitory IgG Fc Receptor FcRIIB on Germinal Center Cells: Implications for Selection of High-Affinity B Cells¹

Kimmel Cancer Center and Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107

The murine low-affinity receptor for IgG, FcRIIB, mediates inhibition of B cell receptor-triggered events in primary B cells. We investigated the expression of FcRIIB on germinal center (GC) cells to better understand its role in memory B cell development. Immunohistological analyses demonstrated differential regulation of FcRIIB on GC cells. Its levels are markedly down-regulated on GC B cells and up-regulated on follicular dendritic cells (FDC) at all times during the GC response. Analyses of surface expression of FcRIIB by flow cytometry and FcRIIB mRNA levels by RT-PCR analysis confirmed that this FcR is down-regulated in GC B cells. In mice lacking FcRIIB, the development of the secondary FDC reticulum in GCs is substantially delayed, although the overall kinetics of the GC response are unaltered. These findings have direct implications for models proposed to account for the selection of high-affinity B cells in the GC and suggest a role for FcRIIB in promoting the maturation of the FDC reticulum.

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