The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Freudenberg, M. A.
Right arrow Articles by Galanos, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Freudenberg, M. A.
Right arrow Articles by Galanos, C.
The Journal of Immunology, 2002, 169: 1665-1668.
Copyright © 2002 by The American Association of Immunologists

Cutting Edge

Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-{gamma} Induction by Gram-Negative Bacteria Based on STAT4 Activation by Type I IFN and IL-18 Signaling1

Marina A. Freudenberg2,*, Thomas Merlin3,*, Christoph Kalis*, Yolande Chvatchko{dagger}, Hella Stübig* and Chris Galanos*

* Max-Planck-Institut für Immunbiologie, Freiburg, Germany; and {dagger} Serono Pharmaceutical Research Institute, Geneva, Switzerland

IFN-{alpha}{beta} is a potent immunoregulatory cytokine involved in the defense against viral and bacterial infections. In this study, we describe an as yet undefined IFN-{alpha}{beta}-dependent pathway of IFN-{gamma} induction in mice. This pathway is based on a synergism of IFN-{alpha}{beta} and IL-18, and is independent of IL-12 signaling yet dependent on STAT4. In contradiction to current dogma, we show further that IFN-{alpha}{beta} alone induces tyrosine phosphorylation of STAT4 in murine splenocytes of different mouse strains. This pathway participates in the induction of IFN-{gamma} by Gram-negative bacteria and is therefore expected to play a role whenever IFN-{alpha} or IFN-{beta} and IL-18 are produced concomitantly during bacterial, viral, or other infections.




This article has been cited by other articles:


Home page
 Infect. Immun.Home page
V. A. K. Rathinam, D. M. Appledorn, K. A. Hoag, A. Amalfitano, and L. S. Mansfield
Campylobacter jejuni-Induced Activation of Dendritic Cells Involves Cooperative Signaling through Toll-Like Receptor 4 (TLR4)-MyD88 and TLR4-TRIF Axes
Infect. Immun., June 1, 2009; 77(6): 2499 - 2507.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. F. Martin, J. C. Dudda, E. Bachtanian, A. Lembo, S. Liller, C. Durr, M. M. Heimesaat, S. Bereswill, G. Fejer, R. Vassileva, et al.
Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity
J. Exp. Med., September 1, 2008; 205(9): 2151 - 2162.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Qiu, Y. Fan, A. G. Joyee, S. Wang, X. Han, H. Bai, L. Jiao, N. Van Rooijen, and X. Yang
Type I IFNs Enhance Susceptibility to Chlamydia muridarum Lung Infection by Enhancing Apoptosis of Local Macrophages
J. Immunol., August 1, 2008; 181(3): 2092 - 2102.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Miyagi, M. P. Gil, X. Wang, J. Louten, W.-M. Chu, and C. A. Biron
High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells
J. Exp. Med., October 1, 2007; 204(10): 2383 - 2396.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. J. Ramos, A. M. Davis, T. C. George, and J. D. Farrar
IFN-{alpha} Is Not Sufficient to Drive Th1 Development Due to Lack of Stable T-bet Expression
J. Immunol., September 15, 2007; 179(6): 3792 - 3803.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. A. Byrnes, D.-Y. Li, K. Park, D. Thompson, C. Mocilnikar, P. Mohan, J. P. Molleston, M. Narkewicz, H. Zhou, S. F. Wolf, et al.
Modulation of the IL-12/IFN-{gamma} axis by IFN-{alpha} therapy for hepatitis C
J. Leukoc. Biol., March 1, 2007; 81(3): 825 - 834.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. Romics Jr, A. Dolganiuc, A. Velayudham, K. Kodys, P. Mandrekar, D. Golenbock, E. Kurt-Jones, and G. Szabo
Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes
J. Leukoc. Biol., December 1, 2005; 78(6): 1255 - 1264.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Shirota, I. Gursel, M. Gursel, and D. M. Klinman
Suppressive Oligodeoxynucleotides Protect Mice from Lethal Endotoxic Shock
J. Immunol., April 15, 2005; 174(8): 4579 - 4583.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Dikopoulos, A. Bertoletti, A. Kroger, H. Hauser, R. Schirmbeck, and J. Reimann
Type I IFN Negatively Regulates CD8+ T Cell Responses through IL-10-Producing CD4+ T Regulatory 1 Cells
J. Immunol., January 1, 2005; 174(1): 99 - 109.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. E. Persky, K. M. Murphy, and J. D. Farrar
IL-12, but Not IFN-{alpha}, Promotes STAT4 Activation and Th1 Development in Murine CD4+ T Cells Expressing a Chimeric Murine/Human Stat2 Gene
J. Immunol., January 1, 2005; 174(1): 294 - 301.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Mattner, A. Wandersee-Steinhauser, A. Pahl, M. Rollinghoff, G. R. Majeau, P. S. Hochman, and C. Bogdan
Protection against Progressive Leishmaniasis by IFN-{beta}
J. Immunol., June 15, 2004; 172(12): 7574 - 7582.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. J. Lund, Z. Chen, J. Scheinin, and R. Lahesmaa
Early Target Genes of IL-12 and STAT4 Signaling in Th Cells
J. Immunol., June 1, 2004; 172(11): 6775 - 6782.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. G. Rothfuchs, C. Trumstedt, H. Wigzell, and M. E. Rottenberg
Intracellular Bacterial Infection-Induced IFN-{gamma} Is Critically but Not Solely Dependent on Toll-Like Receptor 4-Myeloid Differentiation Factor 88-IFN-{alpha}{beta}-STAT1 Signaling
J. Immunol., May 15, 2004; 172(10): 6345 - 6353.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Athie-Morales, H. H. Smits, D. A. Cantrell, and C. M. U. Hilkens
Sustained IL-12 Signaling Is Required for Th1 Development
J. Immunol., January 1, 2004; 172(1): 61 - 69.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
M. A. Freudenberg, C. Kalis, Y. Chvatchko, T. Merlin, M. Gumenscheimer, and C. Galanos
Role of interferons in LPS hypersensitivity
Innate Immunity, October 1, 2003; 9(5): 308 - 312.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
H. Kuipers, D. Hijdra, V. C. de Vries, H. Hammad, J.-B. Prins, A. J. Coyle, H. C. Hoogsteden, and B. N. Lambrecht
Lipopolysaccharide-Induced Suppression of Airway Th2 Responses Does Not Require IL-12 Production by Dendritic Cells
J. Immunol., October 1, 2003; 171(7): 3645 - 3654.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. Melchjorsen, L. N. Sorensen, and S. R. Paludan
Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function
J. Leukoc. Biol., September 1, 2003; 74(3): 331 - 343.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. B. Mailliard, Y.-I. Son, R. Redlinger, P. T. Coates, A. Giermasz, P. A. Morel, W. J. Storkus, and P. Kalinski
Dendritic Cells Mediate NK Cell Help for Th1 and CTL Responses: Two-Signal Requirement for the Induction of NK Cell Helper Function
J. Immunol., September 1, 2003; 171(5): 2366 - 2373.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Krug, R. Veeraswamy, A. Pekosz, O. Kanagawa, E. R. Unanue, M. Colonna, and M. Cella
Interferon-producing Cells Fail to Induce Proliferation of Naive T Cells but Can Promote Expansion and T Helper 1 Differentiation of Antigen-experienced Unpolarized T Cells
J. Exp. Med., April 7, 2003; 197(7): 899 - 906.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Raman, M. H. Kaplan, C. M. Hogaboam, A. Berlin, and N. W. Lukacs
STAT4 Signal Pathways Regulate Inflammation and Airway Physiology Changes in Allergic Airway Inflammation Locally Via Alteration of Chemokines
J. Immunol., April 1, 2003; 170(7): 3859 - 3865.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.