HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Oehen, S. Articles by López-Macías, C. Search for Related Content PubMed PubMed Citation Articles by Oehen, S. Articles by López-Macías, C.

Marginal Zone Macrophages and Immune Responses Against Viruses¹

Stephan Oehen^2,*, Bernhard Odermatt^*, Urs Karrer^3,*, Hans Hengartner^*, Rolf Zinkernagel^* and Constantino López-Macías

^* Institute for Experimental Immunology, University Hospital, Zurich, Switzerland; and Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, México City, México

The effective establishment of antiviral protection requires a coordinated interplay between the innate and adaptive immune system. Using osteopetrotic (op^-/-) mice, this study investigated the influence of marginal zone macrophages in controlling and initiating a protective immune response against a cytopathic vs a non- or low-cytopathic virus. Despite the generation of potent adaptive immune responses, antiviral protection against cytopathic vesicular stomatitis virus critically depended on the presence of marginal zone macrophages. Infection with low doses (100 PFU) of non- or low-cytopathic lymphocytic choriomeningitis virus was rarely cleared and usually resulted in a carrier state in the majority of mice. This shows that the early innate immune system provides an important preparatory phase to the adaptive immune system and is particularly important for antiviral protection.

This article has been cited by other articles:

				J. Louten, N. van Rooijen, and C. A. Biron Type 1 IFN Deficiency in the Absence of Normal Splenic Architecture during Lymphocytic Choriomeningitis Virus Infection. J. Immunol., September 1, 2006; 177(5): 3266 - 3272. [Abstract] [Full Text] [PDF]

				H. C. Probst and M. van den Broek Priming of CTLs by Lymphocytic Choriomeningitis Virus Depends on Dendritic Cells J. Immunol., April 1, 2005; 174(7): 3920 - 3924. [Abstract] [Full Text] [PDF]

				S. Camelo, A. Shanley, A. S. P. Voon, and P. G. McMenamin The Distribution of Antigen in Lymphoid Tissues following Its Injection into the Anterior Chamber of the Rat Eye J. Immunol., May 1, 2004; 172(9): 5388 - 5395. [Abstract] [Full Text] [PDF]

				P. Bjorck Dendritic Cells Exposed to Herpes Simplex Virus In Vivo Do Not Produce IFN-{alpha} after Rechallenge with Virus In Vitro and Exhibit Decreased T Cell Alloreactivity J. Immunol., May 1, 2004; 172(9): 5396 - 5404. [Abstract] [Full Text] [PDF]

				M. A. Nolte, R. Arens, M. Kraus, M. H. J. van Oers, G. Kraal, R. A. W. van Lier, and R. E. Mebius B Cells Are Crucial for Both Development and Maintenance of the Splenic Marginal Zone J. Immunol., March 15, 2004; 172(6): 3620 - 3627. [Abstract] [Full Text] [PDF]

				P. Aichele, J. Zinke, L. Grode, R. A. Schwendener, S. H. E. Kaufmann, and P. Seiler Macrophages of the Splenic Marginal Zone Are Essential for Trapping of Blood-Borne Particulate Antigen but Dispensable for Induction of Specific T Cell Responses J. Immunol., August 1, 2003; 171(3): 1148 - 1155. [Abstract] [Full Text] [PDF]