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DNAX Research, Palo Alto, CA 94304
Skin homing T cells carry memory for cutaneous Ags and play an
important sentinel and effector role in host defense against pathogens
that enter via the skin. CCR10 is a chemokine receptor that is
preferentially expressed among blood leukocytes by a subset of memory
CD4 and CD8 T cells that coexpress the skin-homing receptor cutaneous
lymphocyte Ag (CLA), but not the gut-homing receptor
4
7. Homing and chemokine receptor
coexpression studies detailed in this study suggest that the
CLA+/CCR10+ memory CD4 T cell population
contains members that have access to both secondary lymphoid organ and
skin compartments; and therefore, can act as both "central" and
"effector" memory T cells. Consistent with this effector phenotype,
CLA+/CCR10+ memory CD4 T cells from normal
donors secrete TNF and IFN-
but minimal IL-4 and IL-10 following in
vitro stimulation. Interactions of CCR10 and its skin-associated ligand
CC ligand 27 may play an important role in facilitating memory T
cell entry into cutaneous sites during times of
inflammation.
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