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Cutting Edge |
Departments of
* Medicine and Biochemistry, and
Microbiology and Immunology and Medicine, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202; and Walther Cancer Institute, Indianapolis, IN 46206
A novel cytokine termed IL-17D was cloned using nested RACE PCR.
It is a secreted cytokine with homology to the IL-17 family of
proteins. IL-17D is preferentially expressed in skeletal muscle, brain,
adipose tissue, heart, lung, and pancreas. Treatment of endothelial
cells with purified rIL-17D protein stimulated the production of IL-6,
IL-8, and GM-CSF. The increased expression of IL-8 was found to be
NF-
B-dependent. rIL-17D also demonstrated an inhibitory effect on
hemopoiesis of myeloid progenitor cells in colony formation
assays.
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