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Cutting Edge: IL-17D, a Novel Member of the IL-17 Family, Stimulates Cytokine Production and Inhibits Hemopoiesis¹

Trevor Starnes^*, Hal E. Broxmeyer, Michael J. Robertson^* and Robert Hromas^2,*

Departments of ^* Medicine and Biochemistry, and Microbiology and Immunology and Medicine, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202; and Walther Cancer Institute, Indianapolis, IN 46206

A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-B-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.

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