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Cutting Edge |
* Department of Immunology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany; and
Department of Nephrology, University of Kiel, Kiel, Germany
It has been proposed that expression of the chemokine receptor
CCR7 represents a defining factor for nonpolarized central
(CCR7+) and polarized effector memory (CCR7-)
T cells. In this study, we have tested this hypothesis using in
vivo-activated T cells from P14 and SMARTA TCR-transgenic (tg)
mice specific for MHC class I- and II-restricted epitopes of the
lymphocytic choriomeningitis virus (LCMV) glycoprotein. CCR7 cell
surface expression on TCR-tg cells was monitored with a CC chemokine
ligand 19-Ig fusion protein. CC chemokine ligand 19-Ig staining
separated TCR-tg cells activated by LCMV infection into
CCR7- and CCR7+ effector/memory T cell
populations. Nonetheless, both T cell populations isolated from spleen
and liver produced identical amounts of IFN-
after short-term Ag
stimulation. Furthermore, CCR7+ and CCR7- CD8
TCR-tg cells from LCMV-infected mice exhibited similar lytic activity
against LCMV peptide-coated target cells. These results question the
proposed concept of differential effector cell function of
CCR7+ and CCR7- memory T
cells.
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L. E. Gamadia, E. B. M. Remmerswaal, J. F. Weel, F. Bemelman, R. A. W. van Lier, and I. J. M. Ten Berge Primary immune responses to human CMV: a critical role for IFN-gamma -producing CD4+ T cells in protection against CMV disease Blood, April 1, 2003; 101(7): 2686 - 2692. [Abstract] [Full Text] [PDF]
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J. M. Blander, D. B. Sant'Angelo, D. Metz, S.-W. Kim, R. A. Flavell, K. Bottomly, and C. A. Janeway Jr. A Pool of Central Memory-Like CD4 T Cells Contains Effector Memory Precursors J. Immunol., March 15, 2003; 170(6): 2940 - 2948. [Abstract] [Full Text] [PDF]
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E. M. Aandahl, J. K. Sandberg, K. P. Beckerman, K. Tasken, W. J. Moretto, and D. F. Nixon CD7 Is a Differentiation Marker That Identifies Multiple CD8 T Cell Effector Subsets J. Immunol., March 1, 2003; 170(5): 2349 - 2355. [Abstract] [Full Text] [PDF]
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E. V. Ravkov, C. M. Myrick, and J. D. Altman Immediate Early Effector Functions of Virus-Specific CD8+CCR7+ Memory Cells in Humans Defined by HLA and CC Chemokine Ligand 19 Tetramers J. Immunol., March 1, 2003; 170(5): 2461 - 2468. [Abstract] [Full Text] [PDF]
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R. L. Hengel, V. Thaker, M. V. Pavlick, J. A. Metcalf, G. Dennis Jr., J. Yang, R. A. Lempicki, I. Sereti, and H. C. Lane Cutting Edge: L-Selectin (CD62L) Expression Distinguishes Small Resting Memory CD4+ T Cells That Preferentially Respond to Recall Antigen J. Immunol., January 1, 2003; 170(1): 28 - 32. [Abstract] [Full Text] [PDF]
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