| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Life Sciences, King’s College London, London, United Kingdom
Induced mucosal tolerance has been shown to be beneficial in
preventing or treating a number of murine and human autoimmune
disorders. However, this particular form of therapy has not been
thoroughly tested in systemic lupus erythematosus. In this study, we
investigated the conditions for induction of nasal tolerance using a
histone peptide named H471 expressing a dominant T cell epitope in the
histone protein H4 of mononucleosome in lupus-prone SNF1
female mice. We also tested the effect of chronic peptide nasal
treatment on the development of autoimmune reactivities in these mice.
Results demonstrated that a dose-dependent nasal tolerance to peptide
H471 can be achieved before or after peptide sensitization in
SNF1 mice. In addition, tolerance to mononucleosomes was
induced by nasal instillation of SNF1 mice with H471. This
was accompanied by an increase in IL-10 and suppression of IFN-
production by lymph node cells. Suppression of Th1-type cytokines was
also observed in SNF1 mice that were nasally administered
with H471 before intradermal injection with the peptide. Finally,
chronic nasal instillation of mice with the H471 peptide not only
suppressed the development of autoantibodies, but also altered the
severity of glomerulonephritis in lupus-prone SNF1
mice.
This article has been cited by other articles:
|
|
 |
|
  H. Wu, E. Center, G. Tsokos, and H. Weiner Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells Lupus, June 1, 2009; 18(7): 586 - 596. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Y. Wu, F. J. Quintana, and H. L. Weiner Nasal Anti-CD3 Antibody Ameliorates Lupus by Inducing an IL-10-Secreting CD4+CD25-LAP+ Regulatory T Cell and Is Associated with Down-Regulation of IL-17+CD4+ICOS+CXCR5+ Follicular Helper T Cells J. Immunol., November 1, 2008; 181(9): 6038 - 6050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-K. Kang, M. Liu, and S. K. Datta Low-Dose Peptide Tolerance Therapy of Lupus Generates Plasmacytoid Dendritic Cells That Cause Expansion of Autoantigen-Specific Regulatory T Cells and Contraction of Inflammatory Th17 Cells J. Immunol., June 15, 2007; 178(12): 7849 - 7858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-K. Kang, M. A. Michaels, B. R. Berner, and S. K. Datta Very Low-Dose Tolerance with Nucleosomal Peptides Controls Lupus and Induces Potent Regulatory T Cell Subsets J. Immunol., March 15, 2005; 174(6): 3247 - 3255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C G Katsiari and G C Tsokos Re-establishment of tolerance: the prospect of developing specific treatment for human lupus Lupus, July 1, 2004; 13(7): 485 - 488. [PDF]
|
|
|
|
 |
|
 J.-G. Chai, E. James, H. Dewchand, E. Simpson, and D. Scott Transplantation tolerance induced by intranasal administration of HY peptides Blood, May 15, 2004; 103(10): 3951 - 3959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Y Wu and N A Staines A deficiency of CD4+ CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen Lupus, March 1, 2004; 13(3): 192 - 200. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Takeda, M. Spatz, C. Ruetzler, R. McCarron, K. Becker, J. Hallenbeck, N. Feuerstein, S. Goldman, and G. Feuerstein Induction of Mucosal Tolerance to E-Selectin Prevents Ischemic and Hemorrhagic Stroke in Spontaneously Hypertensive Genetically Stroke-Prone Rats * Editorial Comment Stroke, September 1, 2002; 33(9): 2156 - 2164. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
