| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, United Kingdom; and
Center for Rheumatic Diseases, University Department of Medicine, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, United Kingdom
Transferring collagen-pulsed, bone marrow-derived dendritic cells (DCs) into congenic DBA/1 recipient mice produced arthritis in joints adjacent to the site of DC transfer and could be inhibited by treatment with TNF antagonists. Disease was Ag specific, as transfer of control, unpulsed DCs, or DCs pulsed with OVA did not produce arthritis. In contrast to other experimental arthritis models, DC-induced arthritis localized to the site of injection and did not spontaneously generalize to uninvolved joints, despite the demonstration of circulating collagen-reactive T cells. Similarly, transfer of T cells primed by collagen/DCs was not sufficient to produce arthritis in recipient mice. In collagen/DC-primed mice however, disease could be induced in uninvolved joints by local administration of noncollagen-pulsed DCs and this could be reduced through TNF inhibition. Similarly, injection of collagen/DC-primed mice with low-dose TNF also resulted in local induction of arthritis, as did administration of TNF to mice receiving T cells from collagen/DC but not OVA/DC-primed mice. Thus, we have demonstrated for the first time that administration of collagen-pulsed mature DCs is sufficient for the induction of arthritis. Furthermore, this disease process is mediated through both adaptive and innate effects of DCs; first, priming of autoreactive T cells and, second, induction of local inflammation via mediators such as TNF.
This article has been cited by other articles:
|
|
 |
|
  A. L. Zhang, P. Colmenero, U. Purath, C. Teixeira de Matos, W. Hueber, L. Klareskog, I. H. Tarner, E. G. Engleman, and K. Soderstrom Natural killer cells trigger differentiation of monocytes into dendritic cells Blood, October 1, 2007; 110(7): 2484 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Izawa, N. Ishimaru, K. Moriyama, M. Kohashi, R. Arakaki, and Y. Hayashi Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance Blood, July 1, 2007; 110(1): 242 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T R D J Radstake, K C A M Nabbe, M H Wenink, M F Roelofs, A Oosterlaar, A W T van Lieshout, P Barrera, P L E M van Lent, and W B van den Berg Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc{gamma}RII expression, which has clear functional consequences Ann Rheum Dis, December 1, 2005; 64(12): 1737 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Moghaddami, L. G. Cleland, and G. Mayrhofer MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro Int. Immunol., August 1, 2005; 17(8): 1103 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yoshitomi, N. Sakaguchi, K. Kobayashi, G. D. Brown, T. Tagami, T. Sakihama, K. Hirota, S. Tanaka, T. Nomura, I. Miki, et al. A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice J. Exp. Med., March 21, 2005; 201(6): 949 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A W T van Lieshout, P Barrera, R L Smeets, G J Pesman, P L C M van Riel, W B van den Berg, and T R D J Radstake Inhibition of TNF{alpha} during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF{alpha} blockade in rheumatoid arthritis Ann Rheum Dis, March 1, 2005; 64(3): 408 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Maffia, J. M. Brewer, J. A. Gracie, A. Ianaro, B. P. Leung, P. J. Mitchell, K. M. Smith, I. B. McInnes, and P. Garside Inducing Experimental Arthritis and Breaking Self-Tolerance to Joint-Specific Antigens with Trackable, Ovalbumin-Specific T Cells J. Immunol., July 1, 2004; 173(1): 151 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T R D J Radstake, P L E M van Lent, G J Pesman, A B Blom, F G J Sweep, J Ronnelid, G J Adema, P Barrera, and W B van den Berg High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon Fc{gamma}R triggering Ann Rheum Dis, June 1, 2004; 63(6): 696 - 702. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. S. Davis A Question of Transformation: The Synovial Fibroblast in Rheumatoid Arthritis Am. J. Pathol., May 1, 2003; 162(5): 1399 - 1402. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
