The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mold, C.
Right arrow Articles by Du Clos, T. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mold, C.
Right arrow Articles by Du Clos, T. W.
The Journal of Immunology, 2002, 169: 7019-7025.
Copyright © 2002 by The American Association of Immunologists

C-Reactive Protein Mediates Protection from Lipopolysaccharide Through Interactions With Fc{gamma}R1

Carolyn Mold{ddagger}, Wilfredo Rodriguez{dagger}, Bojana Rodic-Polic{ddagger} and Terry W. Du Clos2,*,{dagger}

* Department of Veterans Affairs Medical Center, Albuquerque, NM 87108; Departments of {dagger} Internal Medicine and {ddagger} Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131

C-reactive protein (CRP) is a component of the acute phase response to infection, inflammation, and trauma. A major activity of acute phase proteins is to limit the inflammatory response. It has been demonstrated that CRP protects mice from lethal doses of LPS. In the mouse, CRP binds to the regulatory receptor, Fc{gamma}RIIb, and to the {gamma}-chain-associated receptor, Fc{gamma}RI. The goal ofthis study was to determine whether Fc{gamma}Rs are necessary for the protective effect of CRP. The ability of CRP to protect mice from a lethal dose of LPS was confirmed using injections of 500 and 250 µg of CRP at 0 and 12 h. CRP treatment of Fc{gamma}RIIb-deficient mice increased mortality after LPS challenge and increased serum levels of TNF and IL-12 in response to LPS. CRP did not protect FcR {gamma}-chain-deficient mice from LPS-induced mortality. Treatment of normal mice, but not {gamma}-chain-deficient mice, with CRP increased IL-10 levels following LPS injection. In vitro, in the presence of LPS, CRP enhanced IL-10 synthesis and inhibited IL-12 synthesis by bone marrow macrophages from normal, but not {gamma}-chain-deficient mice. The protective effect of CRP appears to be mediated by binding to Fc{gamma}RI and Fc{gamma}RII resulting in enhanced secretion of the anti-inflammatory cytokine IL-10 and the down-regulation of IL-12. These results suggest that CRP can alter the cytokine profile of mouse macrophages by acting through Fc{gamma}R leading to a down-regulation of the inflammatory response.




This article has been cited by other articles:


Home page
 J DAIRY SCIHome page
D. G. V. Emmanuel, S. M. Dunn, and B. N. Ametaj
Feeding High Proportions of Barley Grain Stimulates an Inflammatory Response in Dairy Cows
J Dairy Sci, February 1, 2008; 91(2): 606 - 614.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. Mitra, S. Bansal, W. Wang, S. Falk, E. Zolty, and R. W. Schrier
Erythropoietin ameliorates renal dysfunction during endotoxaemia
Nephrol. Dial. Transplant., August 1, 2007; 22(8): 2349 - 2353.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Thomas-Rudolph, T. W. Du Clos, C. M. Snapper, and C. Mold
C-Reactive Protein Enhances Immunity to Streptococcus pneumoniae by Targeting Uptake to Fc{gamma}R on Dendritic Cells
J. Immunol., June 1, 2007; 178(11): 7283 - 7291.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. V. Suresh, S. K. Singh, D. A. Ferguson Jr., and A. Agrawal
Human C-Reactive Protein Protects Mice from Streptococcus pneumoniae Infection without Binding to Pneumococcal C-Polysaccharide
J. Immunol., January 15, 2007; 178(2): 1158 - 1163.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Rodriguez, C. Mold, M. Kataranovski, J. A. Hutt, L. L. Marnell, J. S. Verbeek, and T. W. Du Clos
C-Reactive Protein-Mediated Suppression of Nephrotoxic Nephritis: Role of Macrophages, Complement, and Fc{gamma} Receptors
J. Immunol., January 1, 2007; 178(1): 530 - 538.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
U. Singh, S. Devaraj, M. R. Dasu, D. Ciobanu, J. Reusch, and I. Jialal
C-Reactive Protein Decreases Interleukin-10 Secretion in Activated Human Monocyte-Derived Macrophages via Inhibition of Cyclic AMP Production
Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2469 - 2475.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
K. Nishihira, T. Imamura, A. Yamashita, K. Hatakeyama, Y. Shibata, Y. Nagatomo, H. Date, T. Kita, T. Eto, and Y. Asada
Increased expression of interleukin-10 in unstable plaque obtained by directional coronary atherectomy
Eur. Heart J., July 2, 2006; 27(14): 1685 - 1689.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Mold and T. W. Du Clos
C-Reactive Protein Increases Cytokine Responses to Streptococcus pneumoniae through Interactions with Fc{gamma} Receptors.
J. Immunol., June 15, 2006; 176(12): 7598 - 7604.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Tedgui and Z. Mallat
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Physiol Rev, April 1, 2006; 86(2): 515 - 581.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. V. Suresh, S. K. Singh, D. A. Ferguson Jr., and A. Agrawal
Role of the Property of C-Reactive Protein to Activate the Classical Pathway of Complement in Protecting Mice from Pneumococcal Infection
J. Immunol., April 1, 2006; 176(7): 4369 - 4374.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. P. Schleimer
Innate Immune Responses and Chronic Obstructive Pulmonary Disease: "Terminator" or "Terminator 2"?
Proceedings of the ATS, November 1, 2005; 2(4): 342 - 346.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Cunningham, D. C. Wilcockson, S. Campion, K. Lunnon, and V. H. Perry
Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration
J. Neurosci., October 5, 2005; 25(40): 9275 - 9284.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Black, A. Wilson, and D. Samols
An Intact Phosphocholine Binding Site Is Necessary for Transgenic Rabbit C-Reactive Protein to Protect Mice against Challenge with Platelet-Activating Factor
J. Immunol., July 15, 2005; 175(2): 1192 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Black, I. Kushner, and D. Samols
C-reactive Protein
J. Biol. Chem., November 19, 2004; 279(47): 48487 - 48490.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Chi, E. Messas, R. A. Levine, D. T. Graves, and S. Amar
Interleukin-1 Receptor Signaling Mediates Atherosclerosis Associated With Bacterial Exposure and/or a High-Fat Diet in a Murine Apolipoprotein E Heterozygote Model: Pharmacotherapeutic Implications
Circulation, September 21, 2004; 110(12): 1678 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. B. Bodman-Smith, R. E. Gregory, P. T. Harrison, and J. G. Raynes
Fc{gamma}RIIa expression with Fc{gamma}RI results in C-reactive protein- and IgG-mediated phagocytosis
J. Leukoc. Biol., June 1, 2004; 75(6): 1029 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. M. Hirschfield, J. Herbert, M. C. Kahan, and M. B. Pepys
Human C-Reactive Protein Does Not Protect against Acute Lipopolysaccharide Challenge in Mice
J. Immunol., December 1, 2003; 171(11): 6046 - 6051.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.