| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cutting Edge |
Promoter in the Toll-Like Receptor Signaling1
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation, Suita, Osaka, Japan
MyD88 is a Toll/IL-1 receptor (TIR) domain-containing
adapter common to signaling pathways via Toll-like receptor (TLR)
family. However, accumulating evidence demonstrates the existence of a
MyD88-independent pathway, which may explain unique biological
responses of individual TLRs, particularly TLR3 and TLR4. TIR
domain-containing adapter protein (TIRAP)/MyD88 adapter-like, a
second adapter harboring the TIR domain, is essential for
MyD88-dependent TLR2 and TLR4 signaling pathways, but not for
MyD88-independent pathways. Here, we identified a novel TIR
domain-containing molecule, named TIR domain-containing adapter
inducing IFN-
(TRIF). As is the case in MyD88 and TIRAP,
overexpression of TRIF activated the NF-
B-dependent promoter.
A dominant-negative form of TRIF inhibited TLR2-, TLR4-, and
TLR7-dependent NF-B activation. Furthermore, TRIF, but neither MyD88
nor TIRAP, activated the IFN- promoter. Dominant-negative TRIF
inhibited TLR3-dependent activation of both the NF-B-dependent and
IFN- promoters. TRIF associated with TLR3 and IFN regulatory factor
3. These findings suggest that TRIF is involved in the TLR signaling,
particularly in the MyD88-independent pathway.
This article has been cited by other articles:
|
|
 |
|
  V. D. Menachery and D. A. Leib Control of Herpes Simplex Virus Replication Is Mediated through an Interferon Regulatory Factor 3-Dependent Pathway J. Virol., December 1, 2009; 83(23): 12399 - 12406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Piao, C. Song, H. Chen, M. A. Quevedo Diaz, L. M. Wahl, K. A. Fitzgerald, L. Li, and A. E. Medvedev Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-{beta}-dependent pathways and increases expression of negative regulators of TLR signaling J. Leukoc. Biol., October 1, 2009; 86(4): 863 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F. Kenny, S. Talbot, M. Gong, D. T. Golenbock, C. E. Bryant, and L. A. J. O'Neill MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3 J. Immunol., September 15, 2009; 183(6): 3642 - 3651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Verstak, K. Nagpal, S. P. Bottomley, D. T. Golenbock, P. J. Hertzog, and A. Mansell MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-{kappa}B Proinflammatory Responses J. Biol. Chem., September 4, 2009; 284(36): 24192 - 24203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Li, A. D'Alessio, and J. S. Pober Lipopolysaccharide Can Trigger a Cathepsin B-Dependent Programmed Death Response in Human Endothelial Cells Am. J. Pathol., September 1, 2009; 175(3): 1124 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. de Vos, J. M. Pater, P. S. van den Pangaart, M. D. de Kruif, C. van 't Veer, and T. van der Poll In Vivo Lipopolysaccharide Exposure of Human Blood Leukocytes Induces Cross-Tolerance to Multiple TLR Ligands J. Immunol., July 1, 2009; 183(1): 533 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tirapu, B. Giquel, L. Alexopoulou, S. Uematsu, R. Flavell, S. Akira, and S. S. Diebold PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation Int. Immunol., July 1, 2009; 21(7): 871 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Schwartz, R. Malgor, E. Dickerson, A. T. Weeraratna, A. Slominski, J. Wortsman, N. Harii, A. D. Kohn, R. T. Moon, F. L. Schwartz, et al. Phenylmethimazole Decreases Toll-Like Receptor 3 and Noncanonical Wnt5a Expression in Pancreatic Cancer and Melanoma Together with Tumor Cell Growth and Migration Clin. Cancer Res., June 15, 2009; 15(12): 4114 - 4122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kenzel, S. Santos-Sierra, S. D. Deshmukh, I. Moeller, B. Ergin, K. A. Fitzgerald, E. Lien, S. Akira, D. T. Golenbock, and P. Henneke Role of p38 and Early Growth Response Factor 1 in the Macrophage Response to Group B Streptococcus Infect. Immun., June 1, 2009; 77(6): 2474 - 2481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. K. Rathinam, D. M. Appledorn, K. A. Hoag, A. Amalfitano, and L. S. Mansfield Campylobacter jejuni-Induced Activation of Dendritic Cells Involves Cooperative Signaling through Toll-Like Receptor 4 (TLR4)-MyD88 and TLR4-TRIF Axes Infect. Immun., June 1, 2009; 77(6): 2499 - 2507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, C. Li, P. Xue, B. Zhong, A.-P. Mao, Y. Ran, H. Chen, Y.-Y. Wang, F. Yang, and H.-B. Shu ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response PNAS, May 12, 2009; 106(19): 7945 - 7950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Klaschik, D. Tross, and D. M. Klinman Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo J. Leukoc. Biol., May 1, 2009; 85(5): 788 - 795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. Radhakrishnan, Q. Yu, J. S. Harms, and G. A. Splitter Brucella TIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP J. Biol. Chem., April 10, 2009; 284(15): 9892 - 9898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Mogensen Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses Clin. Microbiol. Rev., April 1, 2009; 22(2): 240 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. De Miranda, K. Yaddanapudi, M. Hornig, and W. I. Lipkin Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5 FASEB J, April 1, 2009; 23(4): 1064 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Remy, P. Blancou, L. Tesson, V. Tardif, R. Brion, P. J. Royer, R. Motterlini, R. Foresti, M. Painchaut, S. Pogu, et al. Carbon Monoxide Inhibits TLR-Induced Dendritic Cell Immunogenicity J. Immunol., February 15, 2009; 182(4): 1877 - 1884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Miyahira, A. Shahangian, S. Hwang, R. Sun, and G. Cheng TANK-Binding Kinase-1 Plays an Important Role during In Vitro and In Vivo Type I IFN Responses to DNA Virus Infections J. Immunol., February 15, 2009; 182(4): 2248 - 2257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Endoh, Y. M. Chung, I. A. Clark, C. L. Geczy, and K. Hsu IL-10-Dependent S100A8 Gene Induction in Monocytes/Macrophages by Double-Stranded RNA J. Immunol., February 15, 2009; 182(4): 2258 - 2268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yanagimoto, K. Tatsuno, S. Okugawa, T. Kitazawa, K. Tsukada, K. Koike, T. Kodama, S. Kimura, Y. Shibasaki, and Y. Ota A Single Amino Acid of Toll-like Receptor 4 That Is Pivotal for Its Signal Transduction and Subcellular Localization J. Biol. Chem., February 6, 2009; 284(6): 3513 - 3520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Murawski, G. N. Bowen, A. M. Cerny, L. J. Anderson, L. M. Haynes, R. A. Tripp, E. A. Kurt-Jones, and R. W. Finberg Respiratory Syncytial Virus Activates Innate Immunity through Toll-Like Receptor 2 J. Virol., February 1, 2009; 83(3): 1492 - 1500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Richez, K. Yasuda, A. A. Watkins, S. Akira, R. Lafyatis, J. M. van Seventer, and I. R. Rifkin TLR4 Ligands Induce IFN-{alpha} Production by Mouse Conventional Dendritic Cells and Human Monocytes after IFN-{beta} Priming J. Immunol., January 15, 2009; 182(2): 820 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Deng, M. Shi, M. Han, J. Zhong, Z. Li, W. Li, Y. Hu, L. Yan, J. Wang, Y. He, et al. Negative Regulation of Virus-triggered IFN-{beta} Signaling Pathway by Alternative Splicing of TBK1 J. Biol. Chem., December 19, 2008; 283(51): 35590 - 35597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Ashtekar, P. Zhang, J. Katz, C. C. S. Deivanayagam, P. Rallabhandi, S. N. Vogel, and S. M. Michalek TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensis J. Leukoc. Biol., December 1, 2008; 84(6): 1434 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-S. Shi and J. H. Kehrl MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages J. Biol. Chem., November 28, 2008; 283(48): 33175 - 33182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chen, R. Sorrentino, K. Shimada, Y. Bulut, T. M. Doherty, T. R. Crother, and M. Arditi Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88-Dependent and -Independent Signaling and Is Reciprocally Modulated by Liver X Receptor Activation J. Immunol., November 15, 2008; 181(10): 7186 - 7193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hu, K.-H. Park-Min, A. Yarilina, and L. B. Ivashkiv Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-{alpha} and PGE2 J. Leukoc. Biol., November 1, 2008; 84(5): 1353 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tamassia, V. Le Moigne, M. Rossato, M. Donini, S. McCartney, F. Calzetti, M. Colonna, F. Bazzoni, and M. A. Cassatella Activation of an Immunoregulatory and Antiviral Gene Expression Program in Poly(I:C)-Transfected Human Neutrophils J. Immunol., November 1, 2008; 181(9): 6563 - 6573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kubota, M. Matsuoka, T.-H. Chang, P. Tailor, T. Sasaki, M. Tashiro, A. Kato, and K. Ozato Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression J. Biol. Chem., September 12, 2008; 283(37): 25660 - 25670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Wilson, P. F. de Sessions, M. A. Leon, and F. Scholle West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal Transduction J. Virol., September 1, 2008; 82(17): 8262 - 8271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shingai, M. Azuma, T. Ebihara, M. Sasai, K. Funami, M. Ayata, H. Ogura, H. Tsutsumi, M. Matsumoto, and T. Seya Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction Int. Immunol., September 1, 2008; 20(9): 1169 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fukuda, T. Watanabe, T. Tokisue, T. Tsujita, S. Nishikawa, T. Hasegawa, T. Seya, and M. Matsumoto Modulation of Double-stranded RNA Recognition by the N-terminal Histidine-rich Region of the Human Toll-like Receptor 3 J. Biol. Chem., August 15, 2008; 283(33): 22787 - 22794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Semnani, P. G. Venugopal, C. A. Leifer, S. Mostbock, H. Sabzevari, and T. B. Nutman Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites Blood, August 15, 2008; 112(4): 1290 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, K. Kimura, R. Yanai, T.-i. Chikama, and T. Nishida Cytokine, Chemokine, and Adhesion Molecule Expression Mediated by MAPKs in Human Corneal Fibroblasts Exposed to Poly(I:C) Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3336 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Huang, D. J. Moore, R. J. Ketchum, C. S. Nunemaker, B. Kovatchev, A. L. McCall, and K. L. Brayman Resolving the Conundrum of Islet Transplantation by Linking Metabolic Dysregulation, Inflammation, and Immune Regulation Endocr. Rev., August 1, 2008; 29(5): 603 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Paulmann, T. Magulski, R. Schwarz, L. Heitmann, B. Flehmig, A. Vallbracht, and A. Dotzauer Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation J. Gen. Virol., July 1, 2008; 89(7): 1593 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hayashi, H. B. Cottam, M. Chan, G. Jin, R. I. Tawatao, B. Crain, L. Ronacher, K. Messer, D. A. Carson, and M. Corr Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7 Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R123 - R132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Abe, M. Matsuda, H. Kobayashi, Y. Miyata, Y. Nakayama, R. Komuro, A. Fukuhara, and I. Shimomura Effects of Statins on Adipose Tissue Inflammation: Their Inhibitory Effect on MyD88-Independent IRF3/IFN-{beta} Pathway in Macrophages Arterioscler Thromb Vasc Biol, May 1, 2008; 28(5): 871 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Dogusan, M. Garcia, D. Flamez, L. Alexopoulou, M. Goldman, C. Gysemans, C. Mathieu, C. Libert, D. L. Eizirik, and J. Rasschaert Double-Stranded RNA Induces Pancreatic {beta}-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways Diabetes, May 1, 2008; 57(5): 1236 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fan, S. Chen, Y. Liu, Y. Lin, H. Liu, L. Guo, B. Lin, S. Huang, and A. Xu Zebrafish TRIF, a Golgi-Localized Protein, Participates in IFN Induction and NF-{kappa}B Activation J. Immunol., April 15, 2008; 180(8): 5373 - 5383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bhushan, S. Tchatalbachev, J. Klug, M. Fijak, C. Pineau, T. Chakraborty, and A. Meinhardt Uropathogenic Escherichia coli Block MyD88-Dependent and Activate MyD88-Independent Signaling Pathways in Rat Testicular Cells J. Immunol., April 15, 2008; 180(8): 5537 - 5547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Velazquez, B. Wei, M. McPherson, L. M. A. Mendoza, S. L. Nguyen, O. Turovskaya, M. Kronenberg, T. T. Huang, M. Schrage, L. N. Lobato, et al. Villous B Cells of the Small Intestine Are Specialized for Invariant NK T Cell Dependence J. Immunol., April 1, 2008; 180(7): 4629 - 4638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kaczorowski, K. P. Mollen, R. Edmonds, and T. R. Billiar Early events in the recognition of danger signals after tissue injury J. Leukoc. Biol., March 1, 2008; 83(3): 546 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Farhat, S. Riekenberg, H. Heine, J. Debarry, R. Lang, J. Mages, U. Buwitt-Beckmann, K. Roschmann, G. Jung, K.-H. Wiesmuller, et al. Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling J. Leukoc. Biol., March 1, 2008; 83(3): 692 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Johnson, X. Li, and E. Pearlman MyD88 Functions as a Negative Regulator of TLR3/TRIF-induced Corneal Inflammation by Inhibiting Activation of c-Jun N-terminal Kinase J. Biol. Chem., February 15, 2008; 283(7): 3988 - 3996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Piao, C. Song, H. Chen, L. M. Wahl, K. A. Fitzgerald, L. A. O'Neill, and A. E. Medvedev Tyrosine Phosphorylation of MyD88 Adapter-like (Mal) Is Critical for Signal Transduction and Blocked in Endotoxin Tolerance J. Biol. Chem., February 8, 2008; 283(6): 3109 - 3119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sillanpaa, P. Kaukinen, K. Melen, and I. Julkunen Hepatitis C virus proteins interfere with the activation of chemokine gene promoters and downregulate chemokine gene expression J. Gen. Virol., February 1, 2008; 89(2): 432 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Randall and S. Goodbourn Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures J. Gen. Virol., January 1, 2008; 89(1): 1 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ghose, D. White, T. Guo, J. Vallejo, and S. J. Karpen Regulation of Hepatic Drug-Metabolizing Enzyme Genes by Toll-Like Receptor 4 Signaling Is Independent of Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein Drug Metab. Dispos., January 1, 2008; 36(1): 95 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Asai, Y. Makimura, A. Kawabata, and T. Ogawa Soluble CD14 Discriminates Slight Structural Differences between Lipid As That Lead to Distinct Host Cell Activation J. Immunol., December 1, 2007; 179(11): 7674 - 7683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. McAleer, D. J. Zammit, L. Lefrancois, R. J. Rossi, and A. T. Vella The Lipopolysaccharide Adjuvant Effect on T Cells Relies on Nonoverlapping Contributions from the MyD88 Pathway and CD11c+ Cells J. Immunol., November 15, 2007; 179(10): 6524 - 6535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Funami, M. Sasai, Y. Ohba, H. Oshiumi, T. Seya, and M. Matsumoto Spatiotemporal Mobilization of Toll/IL-1 Receptor Domain-Containing Adaptor Molecule-1 in Response to dsRNA J. Immunol., November 15, 2007; 179(10): 6867 - 6872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Devaraj, N. Wang, Z. Chen, Z. Chen, M. Tseng, N. Barretto, R. Lin, C. J. Peters, C.-T. K. Tseng, S. C. Baker, et al. Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus J. Biol. Chem., November 2, 2007; 282(44): 32208 - 32221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shingai, T. Ebihara, N. A. Begum, A. Kato, T. Honma, K. Matsumoto, H. Saito, H. Ogura, M. Matsumoto, and T. Seya Differential Type I IFN-Inducing Abilities of Wild-Type versus Vaccine Strains of Measles Virus J. Immunol., November 1, 2007; 179(9): 6123 - 6133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. D. Gilfoy and P. W. Mason West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKR J. Virol., October 15, 2007; 81(20): 11148 - 11158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirata, A. H. Broquet, L. Menchen, and M. F. Kagnoff Activation of Innate Immune Defense Mechanisms by Signaling through RIG-I/IPS-1 in Intestinal Epithelial Cells J. Immunol., October 15, 2007; 179(8): 5425 - 5432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Loiarro, F. Capolunghi, N. Fanto, G. Gallo, S. Campo, B. Arseni, R. Carsetti, P. Carminati, R. De Santis, V. Ruggiero, et al. Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound J. Leukoc. Biol., October 1, 2007; 82(4): 801 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. McCall, N. Harii, C. J. Lewis, R. Malgor, W. Bae Kim, M. Saji, A. D. Kohn, R. T. Moon, and L. D. Kohn High Basal Levels of Functional Toll-Like Receptor 3 (TLR3) and Noncanonical Wnt5a Are Expressed in Papillary Thyroid Cancer and Are Coordinately Decreased by Phenylmethimazole Together with Cell Proliferation and Migration Endocrinology, September 1, 2007; 148(9): 4226 - 4237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Sheedy and L. A. J. O'Neill The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling J. Leukoc. Biol., August 1, 2007; 82(2): 196 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, T. Chen, C. Han, D. He, H. Liu, H. An, Z. Cai, and X. Cao Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4 Blood, August 1, 2007; 110(3): 962 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Diao, S. Li, Y. Tian, M. Zhang, L.-G. Xu, Y. Zhang, R.-P. Wang, D. Chen, Z. Zhai, B. Zhong, et al. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase PNAS, July 10, 2007; 104(28): 11706 - 11711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. J. Roberts, N. Goutagny, P.-Y. Perera, H. Kato, H. Kumar, T. Kawai, S. Akira, R. Savan, D. van Echo, K. A. Fitzgerald, et al. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis J. Exp. Med., July 9, 2007; 204(7): 1559 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mastronardi, H. Tsui, S. Winer, D. Wood, T. Selvanantham, C. Galligan, E. Fish, H-M. Dosch, and M. Moscarello Synergy between paclitaxel plus an exogenous methyl donor in the suppression of murine demyelinating diseases Multiple Sclerosis, June 1, 2007; 13(5): 596 - 609. [Abstract] [PDF]
|
|
|
|
|
|
A. E. Medvedev, W. Piao, J. Shoenfelt, S. H. Rhee, H. Chen, S. Basu, L. M. Wahl, M. J. Fenton, and S. N. Vogel Role of TLR4 Tyrosine Phosphorylation in Signal Transduction and Endotoxin Tolerance J. Biol. Chem., June 1, 2007; 282(22): 16042 - 16053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Venkataraman, M. Valdes, R. Elsby, S. Kakuta, G. Caceres, S. Saijo, Y. Iwakura, and G. N. Barber Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses J. Immunol., May 15, 2007; 178(10): 6444 - 6455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Obonyo, M. Sabet, S. P. Cole, J. Ebmeyer, S. Uematsu, S. Akira, and D. G. Guiney Deficiencies of Myeloid Differentiation Factor 88, Toll-Like Receptor 2 (TLR2), or TLR4 Produce Specific Defects in Macrophage Cytokine Secretion Induced by Helicobacter pylori Infect. Immun., May 1, 2007; 75(5): 2408 - 2414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tarang, A. Sodhi, and P. Chauhan Differential expression of Toll-like receptors in murine peritoneal macrophages in vitro on treatment with cisplatin Int. Immunol., May 1, 2007; 19(5): 635 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ishida, K. Li, M. Yi, and S. M. Lemon p21-activated Kinase 1 Is Activated through the Mammalian Target of Rapamycin/p70 S6 Kinase Pathway and Regulates the Replication of Hepatitis C Virus in Human Hepatoma Cells J. Biol. Chem., April 20, 2007; 282(16): 11836 - 11848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sullivan, J. H. Postlethwait, C. R. Lage, P. J. Millard, and C. H. Kim Evidence for Evolving Toll-IL-1 Receptor-Containing Adaptor Molecule Function in Vertebrates J. Immunol., April 1, 2007; 178(7): 4517 - 4527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Derbigny, S.-C. Hong, M. S. Kerr, M. Temkit, and R. M. Johnson Chlamydia muridarum Infection Elicits a Beta Interferon Response in Murine Oviduct Epithelial Cells Dependent on Interferon Regulatory Factor 3 and TRIF Infect. Immun., March 1, 2007; 75(3): 1280 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Stanley, J. E. Johndrow, P. Manzanillo, and J. S. Cox The Type I IFN Response to Infection with Mycobacterium tuberculosis Requires ESX-1-Mediated Secretion and Contributes to Pathogenesis J. Immunol., March 1, 2007; 178(5): 3143 - 3152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Power, B. Li, M. Yamamoto, S. Akira, and T.-J. Lin A Role of Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-beta in the Host Response to Pseudomonas aeruginosa Lung Infection in Mice J. Immunol., March 1, 2007; 178(5): 3170 - 3176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Winkler, D. Ghadimi, J. Schrezenmeir, and J.-P. Kraehenbuhl Molecular and Cellular Basis of Microflora-Host Interactions J. Nutr., March 1, 2007; 137(3): 756S - 772S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Sacre, A. M. C. Lundberg, E. Andreakos, C. Taylor, M. Feldmann, and B. M. Foxwell Selective Use of TRAM in Lipopolysaccharide (LPS) and Lipoteichoic Acid (LTA) Induced NF-{kappa}B Activation and Cytokine Production in Primary Human Cells: TRAM Is an Adaptor for LPS and LTA Signaling J. Immunol., February 15, 2007; 178(4): 2148 - 2154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pevsner-Fischer, V. Morad, M. Cohen-Sfady, L. Rousso-Noori, A. Zanin-Zhorov, S. Cohen, I. R. Cohen, and D. Zipori Toll-like receptors and their ligands control mesenchymal stem cell functions Blood, February 15, 2007; 109(4): 1422 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-F. Tsan and Baochong Gao Review: Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors Innate Immunity, February 1, 2007; 13(1): 6 - 14. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Nasu, H. Itoh, A. Yuge, M. Nishida, and H. Narahara Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection Hum. Reprod., February 1, 2007; 22(2): 356 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Chen, Y. Benureau, R. Rijnbrand, J. Yi, T. Wang, L. Warter, R. E. Lanford, S. A. Weinman, S. M. Lemon, A. Martin, et al. GB Virus B Disrupts RIG-I Signaling by NS3/4A-Mediated Cleavage of the Adaptor Protein MAVS J. Virol., January 15, 2007; 81(2): 964 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Hise, K. Daehnel, I. Gillette-Ferguson, E. Cho, H. F. McGarry, M. J. Taylor, D. T. Golenbock, K. A. Fitzgerald, J. W. Kazura, and E. Pearlman Innate Immune Responses to Endosymbiotic Wolbachia Bacteria in Brugia malayi and Onchocerca volvulus Are Dependent on TLR2, TLR6, MyD88, and Mal, but Not TLR4, TRIF, or TRAM J. Immunol., January 15, 2007; 178(2): 1068 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bagchi, E. A. Herrup, H. S. Warren, J. Trigilio, H.-S. Shin, C. Valentine, and J. Hellman MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists J. Immunol., January 15, 2007; 178(2): 1164 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Hardarson, J. S. Baker, Z. Yang, E. Purevjav, C.-H. Huang, L. Alexopoulou, N. Li, R. A. Flavell, N. E. Bowles, and J. G. Vallejo Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H251 - H258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhou, B. M. Lapointe, S. R. Clark, L. Zbytnuik, and P. Kubes A Requirement for Microglial TLR4 in Leukocyte Recruitment into Brain in Response to Lipopolysaccharide J. Immunol., December 1, 2006; 177(11): 8103 - 8110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hacker and M. Karin Regulation and Function of IKK and IKK-Related Kinases Sci. Signal., October 17, 2006; 2006(357): re13 - re13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Weighardt, S. Kaiser-Moore, S. Schlautkotter, T. Rossmann-Bloeck, U. Schleicher, C. Bogdan, and B. Holzmann Type I IFN Modulates Host Defense and Late Hyperinflammation in Septic Peritonitis J. Immunol., October 15, 2006; 177(8): 5623 - 5630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Jiang and D. S. Pisetsky The Role of IFN-{alpha} and Nitric Oxide in the Release of HMGB1 by RAW 264.7 Cells Stimulated with Polyinosinic-Polycytidylic Acid or Lipopolysaccharide. J. Immunol., September 1, 2006; 177(5): 3337 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Abrahams, T. M. Schaefer, J. V. Fahey, I. Visintin, J. A. Wright, P. B. Aldo, R. Romero, C. R. Wira, and G. Mor Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C) Hum. Reprod., September 1, 2006; 21(9): 2432 - 2439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Pawar, P. S. Patole, M. Wornle, and H.-J. Anders Microbial nucleic acids pay a Toll in kidney disease Am J Physiol Renal Physiol, September 1, 2006; 291(3): F509 - F516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hayashi, L. C. Hooper, M. S. Chin, C. N. Nagineni, B. Detrick, and J. J. Hooks Herpes simplex virus 1 (HSV-1) DNA and immune complex (HSV-1-human IgG) elicit vigorous interleukin 6 release from infected corneal cells via Toll-like receptors. J. Gen. Virol., August 1, 2006; 87(Pt 8): 2161 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Pietras, S. K. Saha, and Genhong Cheng The interferon response to bacterial and viral infections Innate Immunity, August 1, 2006; 12(4): 246 - 250. [Abstract] [PDF]
|
|
|
|
|
|
S. M. Miggin and L. A. J. O'Neill New insights into the regulation of TLR signaling J. Leukoc. Biol., August 1, 2006; 80(2): 220 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Turner, R. S. Langley, K. L. Johnston, G. Egerton, S. Wanji, and M. J. Taylor Wolbachia Endosymbiotic Bacteria of Brugia malayi Mediate Macrophage Tolerance to TLR- and CD40-Specific Stimuli in a MyD88/TLR2-Dependent Manner J. Immunol., July 15, 2006; 177(2): 1240 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Warger, P. Osterloh, G. Rechtsteiner, M. Fassbender, V. Heib, B. Schmid, E. Schmitt, H. Schild, and M. P. Radsak Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo Blood, July 15, 2006; 108(2): 544 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Bekeredjian-Ding, S. I. Roth, S. Gilles, T. Giese, A. Ablasser, V. Hornung, S. Endres, and G. Hartmann T Cell-Independent, TLR-Induced IL-12p70 Production in Primary Human Monocytes. J. Immunol., June 15, 2006; 176(12): 7438 - 7446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, I. Sabroe, J. D. Hasday, and S. N. Vogel Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease Innate Immunity, June 1, 2006; 12(3): 133 - 150. [Abstract] [PDF]
|
|
|
|
|
|
G. Cheng, J. Zhong, and F. V. Chisari Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms PNAS, May 30, 2006; 103(22): 8499 - 8504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Lopez, J. S. Yount, T. Hermesh, and T. M. Moran Sendai Virus Infection Induces Efficient Adaptive Immunity Independently of Type I Interferons J. Virol., May 1, 2006; 80(9): 4538 - 4545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Rowe, A. F. McGettrick, E. Latz, B. G. Monks, N. J. Gay, M. Yamamoto, S. Akira, L. A. O'Neill, K. A. Fitzgerald, and D. T. Golenbock The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction PNAS, April 18, 2006; 103(16): 6299 - 6304. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
