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The Journal of Immunology, 2002, 169: 6659-6663.
Copyright © 2002 by The American Association of Immunologists

Cutting Edge

Cutting Edge: B7/CD28 Interactions Regulate Cell Cycle Progression Independent of the Strength of TCR Signaling1

Jody L. Bonnevier and Daniel L. Mueller2

Rheumatic and Autoimmune Diseases Division and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455

The role of B7/CD28 signals in Ag-induced cell cycle progression of CD4+ T cells was examined using the technique of CFSE dye dilution and flow cytometry. In wild-type T cells, proliferation was directly related to the concentration of Ag available to the APC. Consistent with this, the rate of G0->G1 cell cycle progression varied with the concentration of Ag. However, cell division by T cell blasts occurred at a constant rate, independent of Ag concentration. G0->G1 phase progression by CD28-deficient CD4+ T cells or wild-type T cells cultured in the presence of neutralizing anti-B7 mAbs was slowed, confirming that a synergy does exist between TCR and CD28 signaling in the initial activation of the T cells. However, unlike the TCR, the strength of CD28 stimulation was also shown to play a unique role in controlling the rate of cell division by T cell blasts.




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