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Cutting Edge |
* Trudeau Institute and
Trudeau Institute Molecular Biology Core Facility, Saranac Lake, NY 12983; and
Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105
Recent studies have shown that CD4+ memory T cells
persist in nonlymphoid organs following infections. However, the
development and phenotype of these peripheral memory cells are poorly
defined. In this study, multimerized MHC-Ig fusion proteins, with a
covalently attached peptide sequence from the Sendai virus
hemagglutinin/neuraminidase gene, have been used to identify
virus-specific CD4+ T cells during Sendai virus infection
and the establishment of peripheral CD4+ memory populations
in the lungs. We show declining frequencies of virus-specific
CD4+ T cells in the lungs over the course of 
3 mo after
infection. Like peripheral CD8+ T cells, the
CD4+ have an acutely activated phenotype, suggesting that a
high level of differentiation is required to reach the airways and
persist as memory cells. Differences in CD25 and CD11a expression
indicate that the CD4+ cells from the lung airways and
parenchyma are distinct memory populations.
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