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CD8+ T Cells in Experimental Cerebral Malaria1
* Département d’Immunologie, Institut Cochin, Institut National de la Santé et de la Recherche Médicale Unité 567, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Hôpital Cochin, Université René Descartes, and
Unité de Parasitologie Biomédicale et Centre National de la Recherche Scientifique Unité de Recherche Associée 1960, Institut Pasteur, Paris, France; and
Department of Cell Biology and Immunology, Faculty of Medicine, Amsterdam, The Netherlands
Cerebral malaria (CM) develops in a small proportion of persons
infected with Plasmodium falciparum and accounts for a
substantial proportion of the mortality due to this parasite. The
actual pathogenic mechanisms are still poorly understood, and in humans
investigations of experimental CM are unethical. Using an established
Plasmodium berghei-mouse CM model, we have investigated
the role of host immune cells at the pathological site, the brain. We
report in this study the detailed quantification and characterization
of cells, which migrated and sequestered to the brain of mice with CM.
We demonstrated that CD8+ 
T cells, which sequester
in the brain at the time when neurological symptoms appear, were
responsible for CM mortality. These observations suggest a mechanism
which unifies disparate observations in humans.
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