| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
* Medicine,
Anatomic Pathology,
Dermatology,
Biochemistry,
¶ Microbiology and Immunology, and ||Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202
Haemophilus ducreyi causes the sexually transmitted
disease chancroid, which facilitates HIV-1 transmission. Skin biopsies
were obtained from subjects experimentally infected with H.
ducreyi to study the evolution of the immune response and
immunophenotypes relevant to transmission of HIV-1. Compared with
peripheral blood, there was an enrichment of T cells and macrophages
after 48 h of infection in the skin. Neutrophils became the
predominant cell type by 7–9 days. By immunohistochemistry,
macrophage-inflammatory protein-1
was not present early in
infection, but was abundant at later stages. RANTES was present
throughout the papular and pustular stages of experimental infection,
but not present in uninfected control skin. Stromal cell-derived
factor-1 was present at low levels in all samples examined. Macrophages
in lesions had significantly increased expression of CCR5 and CXCR4
compared with peripheral blood cells, and CD4 T cells had significant
up-regulation of CCR5. The magnitude of increased expression of these
receptors was not replicated when PBMCs were incubated with H.
ducreyi or H. ducreyi lipooligosaccharide in
vitro. Together with the disruption of mucosal and skin barriers, the
presence of cells with up-regulated HIV-1 coreceptors in H.
ducreyi-infected lesions may provide an environment that
facilitates the acquisition of R5 (CCR5), X4 (CXCR4), and dual-tropic
HIV-1 strains.
This article has been cited by other articles:
|
|
 |
|
  T. L. Humphreys, L. Li, X. Li, D. M. Janowicz, K. R. Fortney, Q. Zhao, W. Li, J. McClintick, B. P. Katz, D. S. Wilkes, et al. Dysregulated Immune Profiles for Skin and Dendritic Cells Are Associated with Increased Host Susceptibility to Haemophilus ducreyi Infection in Human Volunteers Infect. Immun., December 1, 2007; 75(12): 5686 - 5697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hladik, H. Liu, E. Speelmon, D. Livingston-Rosanoff, S. Wilson, P. Sakchalathorn, Y. Hwangbo, B. Greene, T. Zhu, and M. J. McElrath Combined Effect of CCR5-{Delta}32 Heterozygosity and the CCR5 Promoter Polymorphism -2459 A/G on CCR5 Expression and Resistance to Human Immunodeficiency Virus Type 1 Transmission J. Virol., September 15, 2005; 79(18): 11677 - 11684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Humphreys, L. A. Baldridge, S. D. Billings, J. J. Campbell, and S. M. Spinola Trafficking Pathways and Characterization of CD4 and CD8 Cells Recruited to the Skin of Humans Experimentally Infected with Haemophilus ducreyi Infect. Immun., July 1, 2005; 73(7): 3896 - 3902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, G. Li, A. Bafica, M. Pantelic, P. Zhang, H. Broxmeyer, Y. Liu, L. Wetzler, J. J. He, and T. Chen Neisseria gonorrhoeae Enhances Infection of Dendritic Cells by HIV Type 1 J. Immunol., June 15, 2005; 174(12): 7995 - 8002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Prather, M. Bains, R. E. W. Hancock, M. J. Filiatrault, and A. A. Campagnari Differential Expression of Porins OmpP2A and OmpP2B of Haemophilus ducreyi Infect. Immun., November 1, 2004; 72(11): 6271 - 6278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Spinola, C. T. H. Bong, A. L. Faber, K. R. Fortney, S. L. Bennett, C. A. Townsend, B. E. Zwickl, S. D. Billings, T. L. Humphreys, M. E. Bauer, et al. Differences in Host Susceptibility to Disease Progression in the Human Challenge Model of Haemophilus ducreyi Infection Infect. Immun., November 1, 2003; 71(11): 6658 - 6663. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
