| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Induced Galectin-9
Departments of
* Radiology,
Immunology and Immunopathology,
Perinatology and Gynecology, and
Endocrinology, Kagawa Medical University, Kagawa, Japan;
¶ Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan; and
|| First Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
Among galectin family members, galectin-9 was first described as a
potent eosinophil chemoattractant derived from Ag-stimulated T cells.
In the present study a role of galectin-9 in the interaction between
eosinophils and fibroblasts was investigated using a human lung
fibroblast cell line, HFL-1. RT-PCR, real-time PCR, and Western blot
analyses revealed that both galectin-9 mRNA and protein in HFL-1 cells
were up-regulated by IFN-
stimulation. On the one hand, IL-4, known
as a Th2 cytokine, did not affect the galectin-9 expression in HFL-1
cells. We further confirmed that IFN- up-regulated the expression of
galectin-9 in primary human dermal fibroblasts. Flow cytometric
analysis revealed that IFN- up-regulated surface galectin-9
expression on HFL-1 cells. Stimulation of HFL-1 cells with IFN-
up-regulated adhesion of eosinophils, but not neutrophils, to HFL-1
cells. This adherence of eosinophils to HFL-1 cells was inhibited by
both lactose and anti-galectin-9 Ab. These findings demonstrate
that IFN--induced galectin-9 expression in fibroblasts mediates
eosinophil adhesion to the cells, suggesting a crucial role of
galectin-9 in IFN--stimulated fibroblasts as a physiological
modulator at the inflammatory sites.
This article has been cited by other articles:
|
|
 |
|
  L. V Norling, M. Perretti, and D. Cooper Endogenous galectins and the control of the host inflammatory response J. Endocrinol., May 1, 2009; 201(2): 169 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Matsuura, J. Tsukada, T. Mizobe, T. Higashi, F. Mouri, R. Tanikawa, A. Yamauchi, M. Hirashima, and Y. Tanaka Intracellular galectin-9 activates inflammatory cytokines in monocytes. Genes Cells, April 1, 2009; 14(4): 511 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nagahara, T. Arikawa, S. Oomizu, K. Kontani, A. Nobumoto, H. Tateno, K. Watanabe, T. Niki, S. Katoh, M. Miyake, et al. Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions J. Immunol., December 1, 2008; 181(11): 7660 - 7669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Anderson, D. E. Anderson, L. Bregoli, W. D. Hastings, N. Kassam, C. Lei, R. Chandwaskar, J. Karman, E. W. Su, M. Hirashima, et al. Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells Science, November 16, 2007; 318(5853): 1141 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oikawa, Y. Kamimura, H. Akiba, H. Yagita, K. Okumura, H. Takahashi, M. Zeniya, H. Tajiri, and M. Azuma Preferential Involvement of Tim-3 in the Regulation of Hepatic CD8+ T Cells in Murine Acute Graft-versus-Host Disease J. Immunol., October 1, 2006; 177(7): 4281 - 4287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Popovici, M. S. Krause, A. Germeyer, T. Strowitzki, and M. von Wolff Galectin-9: A New Endometrial Epithelial Marker for the Mid- and Late-Secretory and Decidual Phases in Humans J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6170 - 6176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Baba, J. Wada, J. Eguchi, I. Hashimoto, T. Okada, A. Yasuhara, K. Shikata, Y. S. Kanwar, and H. Makino Galectin-9 Inhibits Glomerular Hypertrophy in db/db Diabetic Mice via Cell-Cycle-Dependent Mechanisms J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3222 - 3234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Dai, R. Nakagawa, A. Itoh, H. Murakami, Y. Kashio, H. Abe, S. Katoh, K. Kontani, M. Kihara, S.-L. Zhang, et al. Galectin-9 Induces Maturation of Human Monocyte-Derived Dendritic Cells J. Immunol., September 1, 2005; 175(5): 2974 - 2981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V. Nair, H. Del Valle, P. S. Gross, D. P. Terwilliger, and L. C. Smith Macroarray analysis of coelomocyte gene expression in response to LPS in the sea urchin. Identification of unexpected immune diversity in an invertebrate Physiol Genomics, June 16, 2005; 22(1): 33 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Pelletier, T. Hashidate, T. Urashima, N. Nishi, T. Nakamura, M. Futai, Y. Arata, K.-i. Kasai, M. Hirashima, J. Hirabayashi, et al. Specific Recognition of Leishmania major Poly-{beta}-galactosyl Epitopes by Galectin-9: POSSIBLE IMPLICATION OF GALECTIN-9 IN INTERACTION BETWEEN L. MAJOR AND HOST CELLS J. Biol. Chem., June 13, 2003; 278(25): 22223 - 22230. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
