The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ng, T. F.
Right arrow Articles by Streilein, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ng, T. F.
Right arrow Articles by Streilein, J. W.
The Journal of Immunology, 2002, 169: 5601-5606.
Copyright © 2002 by The American Association of Immunologists

Allogeneic Neonatal Neuronal Retina Grafts Display Partial Immune Privilege in the Subcapsular Space of the Kidney1

Tat Fong Ng, Hideya Osawa, Junko Hori, Michael J. Young and J. Wayne Streilein2

The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114

Transplantation of immature retinal tissues may offer a solution for restoring sight to individuals afflicted with degenerative retinal diseases. Promising results have recently demonstrated that neonatal retinal grafts placed in the eye can survive, differentiate into photoreceptor cells, and respond to evoked electrical stimuli. These transplants, however, were performed in immunologically immature recipients. Since it is important to know whether neonatal neuronal retina (NNR) tissue is immunogenic in immune-competent recipients, and whether this tissue displays inherent immune privilege, we have examined the fate of such grafts placed in a non-immune-privileged site of adult recipient mice. We found that typical, photoreceptor-dominated rosettes formed in differentiating NNR grafts, and that these allografts survived beyond 12 days, whereas genetically identical skin grafts were rejected earlier. Class II MHC-bearing cells of recipient origin were observed along the edge of NNR allografts as early as day 5. Donor-specific delayed hypersensitivity was not detected at 12 days, but did emerge on day 20, coincident with rejection of NNR allografts. Lymph nodes, but not spleens, of mice bearing NNR grafts at 12 days contained regulatory lymphoid cells that suppressed delayed hypersensitivity in naive recipients. We conclude that NNR grafts accommodate and even differentiate in the non-immune-privileged space beneath the kidney capsule. Survival beneath the kidney capsule of NNR allografts, but not skin allografts, at 12 days and beyond implies that NNR tissue possesses inherent immune privilege. The vulnerability of these grafts to rejection by 20 days reveals this privilege to be partial and temporary.




This article has been cited by other articles:


Home page
 IOVSHome page
T. F. Ng, N. Kitaichi, and A. W. Taylor
In Vitro Generated Autoimmune Regulatory T Cells Enhance Intravitreous Allogeneic Retinal Graft Survival
Invest. Ophthalmol. Vis. Sci., November 1, 2007; 48(11): 5112 - 5117.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
T. F. Ng, E. Lavik, H. Keino, A. W. Taylor, R. S. Langer, and M. J. Young
Creating an Immune-Privileged Site Using Retinal Progenitor Cells and Biodegradable Polymers
Stem Cells, June 1, 2007; 25(6): 1552 - 1559.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
M. J. Young, T. Borras, M. Walter, and R. Ritch
Tissue Bioengineering: Potential Applications to Glaucoma
Arch Ophthalmol, December 1, 2005; 123(12): 1725 - 1731.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.