The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hager-Theodorides, A. L.
Right arrow Articles by Crompton, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hager-Theodorides, A. L.
Right arrow Articles by Crompton, T.
The Journal of Immunology, 2002, 169: 5496-5504.
Copyright © 2002 by The American Association of Immunologists

Bone Morphogenetic Protein 2/4 Signaling Regulates Early Thymocyte Differentiation1

Ariadne L. Hager-Theodorides2,*, Susan V. Outram2,*, Divya K. Shah*, Rosa Sacedon{dagger}, Rachel E. Shrimpton*, Angeles Vicente{dagger}, Alberto Varas{dagger} and Tessa Crompton3,*

* Department of Biological Sciences, Imperial College of Science Technology and Medicine, London, United Kingdom; and {dagger} Department of Cell Biology, Complutense University, Madrid, Spain

Bone morphogenetic protein (BMP)2 and BMP4 are involved in the development of many tissues. In this study, we show that BMP2/4 signaling is involved in thymocyte development. Our data suggest that termination of BMP2/4 signaling is necessary for differentiation of CD44+CD25-CD4-CD8- double negative (DN) cells along the T cell lineage. BMP2 and BMP4 are produced by the thymic stroma and the requisite BMP receptor molecules (BMPR-1A, BMPR-1B, BMPR-II), and signal transduction molecules (Smad-1, -5, -8, and -4) are expressed by DN thymocytes. BMP4 inhibits thymocyte proliferation, enhances thymocyte survival, and arrests thymocyte differentiation at the CD44+CD25- DN stage, before T cell lineage commitment. Neutralization of endogenous BMP2 and BMP4 by treatment with the antagonist Noggin promotes and accelerates thymocyte differentiation, increasing the expression of CD2 and the proportion of CD44-CD25- DN cells and CD4+CD8+ double-positive cells. Our study suggests that the BMP2/4 pathway may function in thymic homeostasis by regulating T cell lineage commitment and differentiation.




This article has been cited by other articles:


Home page
 BloodHome page
M. Ravoet, C. Sibille, C. Gu, M. Libin, B. Haibe-Kains, C. Sotiriou, M. Goldman, F. Roufosse, and K. Willard-Gallo
Molecular profiling of CD3-CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways
Blood, October 1, 2009; 114(14): 2969 - 2983.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Hall, P Brogan, S G Haworth, and N Klein
Contribution of inflammation to the pathology of idiopathic pulmonary arterial hypertension in children
Thorax, September 1, 2009; 64(9): 778 - 783.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. A. Sultana, S. Tomita, M. Hamada, Y. Iwanaga, Y. Kitahama, N. Van Khang, S. Hirai, I. Ohigashi, S. Nitta, T. Amagai, et al.
Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development
Blood, March 26, 2009; 113(13): 2976 - 2987.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. V. Outram, A. L. Hager-Theodorides, D. K. Shah, N. J. Rowbotham, E. Drakopoulou, S. E. Ross, B. Lanske, J. T. Dessens, and T. Crompton
Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
Blood, March 5, 2009; 113(10): 2217 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. T. Jeker, T. Barthlott, M. P. Keller, S. Zuklys, M. Hauri-Hohl, C.-X. Deng, and G. A. Hollander
Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells
Blood, November 1, 2008; 112(9): 3688 - 3695.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. C. Wan, J. H. Pomerantz, L. J. Brunet, J.-B. Kim, Y.-F. Chou, B. M. Wu, R. Harland, H. M. Blau, and M. T. Longaker
Noggin Suppression Enhances in Vitro Osteogenesis and Accelerates in Vivo Bone Formation
J. Biol. Chem., September 7, 2007; 282(36): 26450 - 26459.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. L. Chandler, K. J. Chandler, K. A. McFarland, and D. P. Mortlock
Bmp2 Transcription in Osteoblast Progenitors Is Regulated by a Distant 3' Enhancer Located 156.3 Kilobases from the Promoter
Mol. Cell. Biol., April 15, 2007; 27(8): 2934 - 2951.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Assarsson, B. J. Chambers, K. Hogstrand, E. Berntman, C. Lundmark, L. Fedorova, S. Imreh, A. Grandien, S. Cardell, B. Rozell, et al.
Severe Defect in Thymic Development in an Insertional Mutant Mouse Model
J. Immunol., April 15, 2007; 178(8): 5018 - 5027.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Tzachanis, L. Li, E. M. Lafuente, A. Berezovskaya, G. J. Freeman, and V. A. Boussiotis
Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-{beta} signaling in activated T lymphocytes
Blood, April 1, 2007; 109(7): 2944 - 2952.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. R. Nicolls, L. Taraseviciene-Stewart, P. R. Rai, D. B. Badesch, and N. F. Voelkel
Autoimmunity and pulmonary hypertension: a perspective
Eur. Respir. J., December 1, 2005; 26(6): 1110 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. C. Bleul and T. Boehm
BMP Signaling Is Required for Normal Thymus Development
J. Immunol., October 15, 2005; 175(8): 5213 - 5221.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. L. Hager-Theodorides, J. T. Dessens, S. V. Outram, and T. Crompton
The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes
Blood, August 15, 2005; 106(4): 1296 - 1304.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. E. Mick, T. K. Starr, T. M. McCaughtry, L. K. McNeil, and K. A. Hogquist
The Regulated Expression of a Diverse Set of Genes during Thymocyte Positive Selection In Vivo
J. Immunol., November 1, 2004; 173(9): 5434 - 5444.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Gutierrez-Frias, R. Sacedon, C. Hernandez-Lopez, T. Cejalvo, T. Crompton, A. G. Zapata, A. Varas, and A. Vicente
Sonic Hedgehog Regulates Early Human Thymocyte Differentiation by Counteracting the IL-7-Induced Development of CD34+ Precursor Cells
J. Immunol., October 15, 2004; 173(8): 5046 - 5053.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. Schramm, S. Huber, M. Protschka, P. Czochra, J. Burg, E. Schmitt, A. W. Lohse, P. R. Galle, and M. Blessing
TGF{beta} regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo
Int. Immunol., September 1, 2004; 16(9): 1241 - 1249.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Yang, F. M. Murillo, K.-Y. Lin, W. H. Yutzy IV, S. Uematsu, K. Takeda, S. Akira, R. P. Viscidi, and R. B. S. Roden
Human Papillomavirus Type-16 Virus-Like Particles Activate Complementary Defense Responses in Key Dendritic Cell Subpopulations
J. Immunol., August 15, 2004; 173(4): 2624 - 2631.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. K. Shah, A. L. Hager-Theodorides, S. V. Outram, S. E. Ross, A. Varas, and T. Crompton
Reduced Thymocyte Development in Sonic Hedgehog Knockout Embryos
J. Immunol., February 15, 2004; 172(4): 2296 - 2306.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. T. Tsai, R. A. Lee, and H. Wu
BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis
Blood, December 1, 2003; 102(12): 3947 - 3953.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.