The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maurik, A. v.
Right arrow Articles by Jones, N. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maurik, A. v.
Right arrow Articles by Jones, N. D.
The Journal of Immunology, 2002, 169: 5401-5404.
Copyright © 2002 by The American Association of Immunologists

Cutting Edge

Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy1

Andre van Maurik, Manuela Herber, Kathryn J. Wood and Nick D. Jones2

Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8+ T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4+CD25+ regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8+ T cells.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
P. M. Porrett, X. Yuan, D. F. LaRosa, P. T. Walsh, J. Yang, W. Gao, P. Li, J. Zhang, J. M. Ansari, W. W. Hancock, et al.
Mechanisms Underlying Blockade of Allograft Acceptance by TLR Ligands
J. Immunol., August 1, 2008; 181(3): 1692 - 1699.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Carvalho-Gaspar, N. D. Jones, S. Luo, L. Martin, M. O. Brook, and K. J. Wood
Location and Time-Dependent Control of Rejection by Regulatory T Cells Culminates in a Failure to Generate Memory T Cells
J. Immunol., May 15, 2008; 180(10): 6640 - 6648.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Razmara, B. Hilliard, A. K. Ziarani, Y. H. Chen, and M. L. Tykocinski
CTLA-4{middle dot}Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells
Int. Immunol., April 1, 2008; 20(4): 471 - 483.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Demirkiran, B. M. Bosma, A. Kok, C. C. Baan, H. J. Metselaar, J. N. M. IJzermans, H. W. Tilanus, J. Kwekkeboom, and L. J. W. van der Laan
Allosuppressive Donor CD4+CD25+ Regulatory T Cells Detach from the Graft and Circulate in Recipients after Liver Transplantation
J. Immunol., May 15, 2007; 178(10): 6066 - 6072.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Golshayan, S. Jiang, J. Tsang, M. I. Garin, C. Mottet, and R. I. Lechler
In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance
Blood, January 15, 2007; 109(2): 827 - 835.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Toda and C. A. Piccirillo
Development and function of naturally occurring CD4+CD25+ regulatory T cells
J. Leukoc. Biol., September 1, 2006; 80(3): 458 - 470.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. J. A. Coenen, H. J. P. M. Koenen, E. van Rijssen, L. Boon, I. Joosten, and L. B. Hilbrands
CTLA-4 Engagement and Regulatory CD4+CD25+ T Cells Independently Control CD8+-Mediated Responses under Costimulation Blockade
J. Immunol., May 1, 2006; 176(9): 5240 - 5246.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. D. Jones, M. Carvalho-Gaspar, S. Luo, M. O. Brook, L. Martin, and K. J. Wood
Effector and Memory CD8+ T Cells Can Be Generated in Response to Alloantigen Independently of CD4+ T Cell Help
J. Immunol., February 15, 2006; 176(4): 2316 - 2323.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
S. G. Zheng, L. Meng, J. H. Wang, M. Watanabe, M. L. Barr, D. V. Cramer, J. D. Gray, and D. A. Horwitz
Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient
Int. Immunol., February 1, 2006; 18(2): 279 - 289.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
W Chalermskulrat, K P McKinnon, W J Brickey, I P Neuringer, R C Park, D G Sterka, B R Long, P McNeillie, R J Noelle, J P Ting, et al.
Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance
Thorax, January 1, 2006; 61(1): 61 - 67.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. E. Lunsford, M. A. Koester, A. M. Eiring, P. H. Horne, D. Gao, and G. L. Bumgardner
Targeting LFA-1 and CD154 Suppresses the In Vivo Activation and Development of Cytolytic (CD4-Independent) CD8+ T Cells
J. Immunol., December 15, 2005; 175(12): 7855 - 7866.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
F. Ghiringhelli, C. Menard, M. Terme, C. Flament, J. Taieb, N. Chaput, P. E. Puig, S. Novault, B. Escudier, E. Vivier, et al.
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-{beta}-dependent manner
J. Exp. Med., October 17, 2005; 202(8): 1075 - 1085.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. J. Mekala, R. S. Alli, and T. L. Geiger
IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes
PNAS, August 16, 2005; 102(33): 11817 - 11822.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. A. Quezada, K. Bennett, B. R. Blazar, A. Y. Rudensky, S. Sakaguchi, and R. J. Noelle
Analysis of the Underlying Cellular Mechanisms of Anti-CD154-Induced Graft Tolerance: The Interplay of Clonal Anergy and Immune Regulation
J. Immunol., July 15, 2005; 175(2): 771 - 779.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Karim, G. Feng, K. J. Wood, and A. R. Bushell
CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation
Blood, June 15, 2005; 105(12): 4871 - 4877.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
D. T. Nardelli, J. P. Cloute, K. H. K. Luk, J. Torrealba, T. F. Warner, S. M. Callister, and R. F. Schell
CD4+ CD25+ T Cells Prevent Arthritis Associated with Borrelia Vaccination and Infection
Clin. Vaccine Immunol., June 1, 2005; 12(6): 786 - 792.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. G. Heuer, T. Zhang, J. Zhao, C. Ding, M. Cramer, K. L. Justen, S. L. Vonderfecht, and S. Na
Adoptive Transfer of In Vitro-Stimulated CD4+CD25+ Regulatory T Cells Increases Bacterial Clearance and Improves Survival in Polymicrobial Sepsis
J. Immunol., June 1, 2005; 174(11): 7141 - 7146.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Bushell, E. Jones, A. Gallimore, and K. Wood
The Generation of CD25+CD4+ Regulatory T Cells That Prevent Allograft Rejection Does Not Compromise Immunity to a Viral Pathogen
J. Immunol., March 15, 2005; 174(6): 3290 - 3297.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. J. Mekala and T. L. Geiger
Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes
Blood, March 1, 2005; 105(5): 2090 - 2092.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Metzler, P. Gfeller, M. Bigaud, J. Li, G. Wieczorek, C. Heusser, P. Lake, and A. Katopodis
Combinations of Anti-LFA-1, Everolimus, Anti-CD40 Ligand, and Allogeneic Bone Marrow Induce Central Transplantation Tolerance through Hemopoietic Chimerism, Including Protection from Chronic Heart Allograft Rejection
J. Immunol., December 1, 2004; 173(11): 7025 - 7036.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Weiss, V. Donkova-Petrini, L. Caccavelli, M. Balbo, C. Carbonneil, and Y. Levy
Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
Blood, November 15, 2004; 104(10): 3249 - 3256.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Zheng, B. Wang, and A. Chen
The 4-1BB Costimulation Augments the Proliferation of CD4+CD25+ Regulatory T Cells
J. Immunol., August 15, 2004; 173(4): 2428 - 2434.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Graca, A. Le Moine, C.-Y. Lin, P. J. Fairchild, S. P. Cobbold, and H. Waldmann
Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+ T cells
PNAS, July 6, 2004; 101(27): 10122 - 10126.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. R. Karlsson, J. Rugtveit, and P. Brandtzaeg
Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy
J. Exp. Med., June 21, 2004; 199(12): 1679 - 1688.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
Q. Tang, K. J. Henriksen, M. Bi, E. B. Finger, G. Szot, J. Ye, E. L. Masteller, H. McDevitt, M. Bonyhadi, and J. A. Bluestone
In Vitro-expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes
J. Exp. Med., June 7, 2004; 199(11): 1455 - 1465.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. L. Sumpter and D. S. Wilkes
Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1129 - L1139.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
O. Joffre, N. Gorsse, P. Romagnoli, D. Hudrisier, and J. P. M. van Meerwijk
Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes
Blood, June 1, 2004; 103(11): 4216 - 4221.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
B. K. Choi, J. S. Bae, E. M. Choi, W. J. Kang, S. Sakaguchi, D. S. Vinay, and B. S. Kwon
4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells
J. Leukoc. Biol., May 1, 2004; 75(5): 785 - 791.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. van Maurik, B. F. de St. Groth, K. J. Wood, and N. D. Jones
Dependency of Direct Pathway CD4+ T Cells on CD40-CD154 Costimulation Is Determined by Nature and Microenvironment of Primary Contact with Alloantigen
J. Immunol., February 15, 2004; 172(4): 2163 - 2170.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Stanzani, S. L. R. Martins, R. M. Saliba, L. S. St. John, S. Bryan, D. Couriel, J. McMannis, R. E. Champlin, J. J. Molldrem, and K. V. Komanduri
CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans
Blood, February 1, 2004; 103(3): 1140 - 1146.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Karim, C. I. Kingsley, A. R. Bushell, B. S. Sawitzki, and K. J. Wood
Alloantigen-Induced CD25+CD4+ Regulatory T Cells Can Develop In Vivo from CD25-CD4+ Precursors in a Thymus-Independent Process
J. Immunol., January 15, 2004; 172(2): 923 - 928.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Dubois, L. Chapat, A. Goubier, M. Papiernik, J.-F. Nicolas, and D. Kaiserlian
Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation
Blood, November 1, 2003; 102(9): 3295 - 3301.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. Yamazaki, T. Iyoda, K. Tarbell, K. Olson, K. Velinzon, K. Inaba, and R. M. Steinman
Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells
J. Exp. Med., July 21, 2003; 198(2): 235 - 247.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Pearson, T. G. Markees, D. V. Serreze, M. A. Pierce, M. P. Marron, L. S. Wicker, L. B. Peterson, L. D. Shultz, J. P. Mordes, A. A. Rossini, et al.
Genetic Disassociation of Autoimmunity and Resistance to Costimulation Blockade-Induced Transplantation Tolerance in Nonobese Diabetic Mice
J. Immunol., July 1, 2003; 171(1): 185 - 195.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. E. Phillips, T. G. Markees, J. P. Mordes, D. L. Greiner, and A. A. Rossini
Blockade of CD40-Mediated Signaling Is Sufficient for Inducing Islet But Not Skin Transplantation Tolerance
J. Immunol., March 15, 2003; 170(6): 3015 - 3023.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.