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The Journal of Immunology, 2002, 169: 63-67.
Copyright © 2002 by The American Association of Immunologists

IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice

Katrin Peter*, Michael J. Brunda{dagger} and Giampietro Corradin1,*

* Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland; and {dagger} Department of Oncology, Hoffmann-LaRoche, Nutley, NJ 07110

The injection of a mixture of bona fide T cell epitopes can lead to the occurrence of immunodominance, meaning that the immune response is focused on the recognition of a single epitope or a small portion of the epitopes injected. We have previously demonstrated that the administration of rIL-12 can counteract immunodominance in BALB/c mice. In this study, we show that the administration of rIL-12 to HLA-A2.1 transgenic mice (A2kb mice) abrogates specifically the immune response against HLA-A2.1-restricted HIV epitopes in the spleen. This lack of immune response is most probably due to a transient depletion of B cells, T cells, macrophages, and dendritic cells in this organ. Therefore, our study explains the mechanism of immunosuppression by rIL-12 in vivo.




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