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During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair
Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center, Nijmegen, The Netherlands
Osteoarthritis has as main characteristics the degradation of
articular cartilage and the formation of new bone at the joint edges,
so-called osteophytes. In this study enhanced expression of TGF-
1
and -3 was detected in developing osteophytes and articular
cartilage during murine experimental osteoarthritis. To determine the
role of endogenous TGF- on osteophyte formation and articular
cartilage, TGF- activity was blocked via a scavenging soluble
TGF--RII. Our results clearly show that inhibition of endogenous
TGF- nearly completely prevented osteophyte formation. In contrast,
treatment with recombinant soluble TGF--RII markedly enhanced
articular cartilage proteoglycan loss and reduced the thickness of
articular cartilage. In conclusion, we show for the first time that
endogenous TGF- is a crucial factor in the process of osteophyte
formation and has an important function in protection against cartilage
loss.
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