| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Promotes Tumor Growth of Lewis Lung Carcinoma by Induction of Angiogenic Factors: In Vivo Analysis of Tumor-Stromal Interaction1
* Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan; and
Department of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Tokyo, Japan
Inflammatory conditions are associated with tumor development.
IL-1
is a multifunctional and proinflammatory cytokine that affects
nearly all types of cells. To investigate the role of IL-1 in tumor
growth in vivo, we transduced the retroviral vector coding human
IL-1 gene into mouse Lewis lung carcinoma
(LLC) cells and subsequently inoculated the transformant (LLC/IL-1)
to syngeneic C57BL/6 mice. Tumors derived from LLC/IL-1 grew faster
(240%, day 18, vs null-vector control LLC/neo; p
< 0.01) and showed more abundant vasculature (250%, vs LLC/neo;
p < 0.05), whereas LLC/IL-1 cells, LLC/neo
cells, and wild-type LLC cells did not show any significant difference
in the growth rate in vitro. As compared with LLC/neo cells,
LLC/IL-1 cells secreted 2-fold the amount of vascular endothelial
growth factor and >10-fold the amount of macrophage-inflammatory
protein-2 (CXCL2), one of whose main functions is angiogenesis.
Although LLC/IL-1 itself did not secrete hepatocyte growth factor
(HGF), the tumor derived from LLC/IL-1 cells also contained a
>4-fold higher concentration of HGF, another angiogenic factor.
In situ hybridization of HGF mRNA in LLC/IL-1 tumor sections
demonstrated that stromal fibroblasts and infiltrating cells
overexpressed HGF mRNA. Moreover, when cultured in the presence of HGF
in vitro, LLC/IL-1 cells secreted even larger amounts of vascular
endothelial growth factor and macrophage-inflammatory protein-2. The
antiangiogenic agent TNP-470 and anti-CXCR2 Ab inhibited the tumor
growth of LLC/IL-1 cells in vivo. These results indicated that
secreting IL-1 into the tumor milieu induces several angiogenic
factors from tumor and stromal cells and thus promotes tumor growth
through hyperneovascularization.
This article has been cited by other articles:
|
|
 |
|
  H. Sun, W.-C. Chung, S.-H. Ryu, Z. Ju, H. T. Tran, E. Kim, J. M. Kurie, and J. S. Koo Cyclic AMP-Responsive Element Binding Protein- and Nuclear Factor-{kappa}B-Regulated CXC Chemokine Gene Expression in Lung Carcinogenesis Cancer Prevention Research, October 1, 2008; 1(5): 316 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Arnold, J. He, A. Remo, D. Ritsick, Q. Yin-Goen, J. D. Lambeth, M. W. Datta, A. N. Young, and J. A. Petros Nox1 Expression Determines Cellular Reactive Oxygen and Modulates c-fos-Induced Growth Factor, Interleukin-8, and Cav-1 Am. J. Pathol., December 1, 2007; 171(6): 2021 - 2032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Hussain, L.-Y. Kong, J. Jordan, C. Conrad, T. Madden, I. Fokt, W. Priebe, and A. B. Heimberger A Novel Small Molecule Inhibitor of Signal Transducers and Activators of Transcription 3 Reverses Immune Tolerance in Malignant Glioma Patients Cancer Res., October 15, 2007; 67(20): 9630 - 9636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nakao, Y. Hata, M. Miura, K. Noda, Y. N. Kimura, S. Kawahara, T. Kita, T. Hisatomi, T. Nakazawa, Y. Jin, et al. Dexamethasone Inhibits Interleukin-1{beta}-Induced Corneal Neovascularization: Role of Nuclear Factor-{kappa}B-Activated Stromal Cells in Inflammatory Angiogenesis Am. J. Pathol., September 1, 2007; 171(3): 1058 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sinha, V. K. Clements, A. M. Fulton, and S. Ostrand-Rosenberg Prostaglandin E2 Promotes Tumor Progression by Inducing Myeloid-Derived Suppressor Cells Cancer Res., May 1, 2007; 67(9): 4507 - 4513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shao and H. Sheng Prostaglandin E2 Induces the Expression of IL-1{alpha} in Colon Cancer Cells J. Immunol., April 1, 2007; 178(7): 4097 - 4103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Krelin, E. Voronov, S. Dotan, M. Elkabets, E. Reich, M. Fogel, M. Huszar, Y. Iwakura, S. Segal, C. A. Dinarello, et al. Interleukin-1{beta}-Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen-Induced Tumors Cancer Res., February 1, 2007; 67(3): 1062 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. M. Dirkx, M. G. A. oude Egbrink, J. Wagstaff, and A. W. Griffioen Monocyte/macrophage infiltration in tumors: modulators of angiogenesis J. Leukoc. Biol., December 1, 2006; 80(6): 1183 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tateno, T. Minamino, H. Toko, H. Akazawa, N. Shimizu, S. Takeda, T. Kunieda, H. Miyauchi, T. Oyama, K. Matsuura, et al. Critical Roles of Muscle-Secreted Angiogenic Factors in Therapeutic Neovascularization Circ. Res., May 12, 2006; 98(9): 1194 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Elaraj, D. M. Weinreich, S. Varghese, M. Puhlmann, S. M. Hewitt, N. M. Carroll, E. D. Feldman, E. M. Turner, and H. R. Alexander The Role of Interleukin 1 in Growth and Metastasis of Human Cancer Xenografts Clin. Cancer Res., February 15, 2006; 12(4): 1088 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Kollmar, C. Scheuer, M. D. Menger, and M. K. Schilling Macrophage Inflammatory Protein-2 Promotes Angiogenesis, Cell Migration, and Tumor Growth in Hepatic Metastasis Ann. Surg. Oncol., February 1, 2006; 13(2): 263 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bunt, P. Sinha, V. K. Clements, J. Leips, and S. Ostrand-Rosenberg Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression J. Immunol., January 1, 2006; 176(1): 284 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Berdugo, C. Andrieu-Soler, M. Doat, Y. Courtois, D. BenEzra, and F. Behar-Cohen Downregulation of IRS-1 Expression Causes Inhibition of Corneal Angiogenesis Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 4072 - 4078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-h. Lee, M. Nishino, T. Mazumdar, G. E. Garcia, M. Galfione, F. L. Lee, C. L. Lee, A. Liang, J. Kim, L. Feng, et al. 16-kDa Prolactin Down-Regulates Inducible Nitric Oxide Synthase Expression through Inhibition of the Signal Transducer and Activator of Transcription 1/IFN Regulatory Factor-1 Pathway Cancer Res., September 1, 2005; 65(17): 7984 - 7992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Graziano, A. Ruzzo, D. Santini, B. Humar, G. Tonini, V. Catalano, R. Berardi, F. Pizzagalli, F. Arduini, I. Bearzi, et al. Prognostic Role of Interleukin-1{beta} Gene and Interleukin-1 Receptor Antagonist Gene Polymorphisms in Patients With Advanced Gastric Cancer J. Clin. Oncol., April 1, 2005; 23(10): 2339 - 2345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fan, O. Stoeltzing, W. Liu, M. F. McCarty, Y. D. Jung, N. Reinmuth, and L. M. Ellis Interleukin-1{beta} Regulates Angiopoietin-1 Expression in Human Endothelial Cells Cancer Res., May 1, 2004; 64(9): 3186 - 3190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Biswas, K. Banerjee, B. Kim, and B. T. Rouse Mice Transgenic for IL-1 Receptor Antagonist Protein Are Resistant to Herpetic Stromal Keratitis: Possible Role for IL-1 in Herpetic Stromal Keratitis Pathogenesis J. Immunol., March 15, 2004; 172(6): 3736 - 3744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Keane, J. A. Belperio, Y. Y. Xue, M. D. Burdick, and R. M. Strieter Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer J. Immunol., March 1, 2004; 172(5): 2853 - 2860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yamanaka, T. Morisaki, H. Nakashima, A. Tasaki, M. Kubo, H. Kuga, C. Nakahara, K. Nakamura, H. Noshiro, T. Yao, et al. Interleukin 1{beta} Enhances Invasive Ability of Gastric Carcinoma through Nuclear Factor-{kappa}B Activation Clin. Cancer Res., March 1, 2004; 10(5): 1853 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. KUWANO, S. NAKAO, H. YAMAMOTO, M. TSUNEYOSHI, T. YAMAMOTO, M. KUWANO, and M. ONO Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis FASEB J, February 1, 2004; 18(2): 300 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Song, E. Voronov, T. Dvorkin, E. Fima, E. Cagnano, D. Benharroch, Y. Shendler, O. Bjorkdahl, S. Segal, C. A. Dinarello, et al. Differential Effects of IL-1{alpha} and IL-1{beta} on Tumorigenicity Patterns and Invasiveness J. Immunol., December 15, 2003; 171(12): 6448 - 6456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Weinreich, D. M. Elaraj, M. Puhlmann, S. M. Hewitt, N. M. Carroll, E. D. Feldman, E. M. Turner, P. J. Spiess, and H. R. Alexander Effect of Interleukin 1 Receptor Antagonist Gene Transduction on Human Melanoma Xenografts in Nude Mice Cancer Res., September 15, 2003; 63(18): 5957 - 5961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Srisuma, S. S. Biswal, W. A. Mitzner, S. J. Gallagher, K. H. Mai, and E. M. Wagner Identification of Genes Promoting Angiogenesis in Mouse Lung by Transcriptional Profiling Am. J. Respir. Cell Mol. Biol., August 1, 2003; 29(2): 172 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Voronov, D. S. Shouval, Y. Krelin, E. Cagnano, D. Benharroch, Y. Iwakura, C. A. Dinarello, and R. N. Apte IL-1 is required for tumor invasiveness and angiogenesis PNAS, March 4, 2003; 100(5): 2645 - 2650. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
