| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratories of
* Immunology,
Bacteriology and Medical Mycology, and
Virology, Istituto Superiore di Sanità, Rome, Italy;
Laboratory of Cytokine Signaling, Institut Pasteur, Paris, France; and
¶ Institute of Molecular Genetics, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5124, Montpellier, France
Type I IFN regulates different aspects of the immune response,
inducing a cell-mediated immunity. We have recently shown that the
infection of dendritic cells (DC) with Mycobacterium
tuberculosis (Mtb) induces IFN-
. In this work we have
monitored a rapid induction of IFN-
followed by the delayed
production of the IFN-1 and/or -13 subtypes. The Mtb infection
rapidly activates the NF-
B complex and stimulates the
phosphorylation of IFN regulatory factor (IRF)-3, events known to
induce IFN- expression in viral infection. In turn, the autocrine
production of IFN- induces the IFN-stimulated genes that contain
binding sites for activated STATs in their promoters. Among the
IFN-stimulated genes induced in DC through STAT activation are IRF-1
and IRF-7. The expression of IRF-1 appears to be dependent on the
sequential activation of NF-B and STAT-1. Once expressed, IRF-1 may
further stimulate the transcription of IFN-. Induction
of IRF-7 is also regulated at the transcriptional level through the
binding of phosphorylated STAT-1 and STAT-2, forming the IFN-stimulated
gene factor-3 complex. In turn, the IRF-1 and IRF-7 expression appears
to be required for the delayed induction of the IFN-1/13
genes. Although correlative, our results strongly support the
existence of a cascade of molecular events in Mtb-infected DC. Upon
infection, constitutively expressed NF-B and IRF-3 are activated and
likely contribute to the rapid IFN- expression. In turn,
IFN--induced IRF-1 and IRF-7 may cooperate toward induction of
IFN-1/13 if infection persists and these factors are
activated.
This article has been cited by other articles:
|
|
 |
|
  M. Parcina, C. Wendt, F. Goetz, R. Zawatzky, U. Zahringer, K. Heeg, and I. Bekeredjian-Ding Staphylococcus aureus-Induced Plasmacytoid Dendritic Cell Activation Is Based on an IgG-Mediated Memory Response J. Immunol., September 15, 2008; 181(6): 3823 - 3833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Severa, M. E. Remoli, E. Giacomini, V. Annibali, V. Gafa, R. Lande, M. Tomai, M. Salvetti, and E. M. Coccia Sensitization to TLR7 Agonist in IFN-beta-Preactivated Dendritic Cells J. Immunol., May 15, 2007; 178(10): 6208 - 6216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wang, H. D. Edington, U. N.M. Rao, D. M. Jukic, S. R. Land, S. Ferrone, and J. M. Kirkwood Modulation of Signal Transducers and Activators of Transcription 1 and 3 Signaling in Melanoma by High-Dose IFN{alpha}2b Clin. Cancer Res., March 1, 2007; 13(5): 1523 - 1531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Remoli, J. Ragimbeau, E. Giacomini, V. Gafa, M. Severa, R. Lande, S. Pellegrini, and E. M. Coccia NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation J. Leukoc. Biol., January 1, 2007; 81(1): 355 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Penna, S. Amuchastegui, N. Giarratana, K. C. Daniel, M. Vulcano, S. Sozzani, and L. Adorini 1,25-Dihydroxyvitamin D3 Selectively Modulates Tolerogenic Properties in Myeloid but Not Plasmacytoid Dendritic Cells J. Immunol., January 1, 2007; 178(1): 145 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J Lengi, R. A Phillips, E. Karpuzoglu, and S. A. Ahmed 17{beta}-Estradiol downregulates interferon regulatory factor-1 in murine splenocytes J. Mol. Endocrinol., December 1, 2006; 37(3): 421 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Raghuraman, Y. Geng, and C.-R. Wang IFN-beta-Mediated Up-Regulation of CD1d in Bacteria-Infected APCs J. Immunol., December 1, 2006; 177(11): 7841 - 7848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Romieu-Mourez, M. Solis, A. Nardin, D. Goubau, V. Baron-Bodo, R. Lin, B. Massie, M. Salcedo, and J. Hiscott Distinct Roles for IFN Regulatory Factor (IRF)-3 and IRF-7 in the Activation of Antitumor Properties of Human Macrophages Cancer Res., November 1, 2006; 66(21): 10576 - 10585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Fanning, T. C. George, D. Feng, S. B. Feldman, N. J. Megjugorac, A. G. Izaguirre, and P. Fitzgerald-Bocarsly Receptor Cross-Linking on Human Plasmacytoid Dendritic Cells Leads to the Regulation of IFN-{alpha} Production J. Immunol., November 1, 2006; 177(9): 5829 - 5839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Giacomini, A. Sotolongo, E. Iona, M. Severa, M. E. Remoli, V. Gafa, R. Lande, L. Fattorini, I. Smith, R. Manganelli, et al. Infection of Human Dendritic Cells with a Mycobacterium tuberculosis sigE Mutant Stimulates Production of High Levels of Interleukin-10 but Low Levels of CXCL10: Impact on the T-Cell Response. Infect. Immun., June 1, 2006; 74(6): 3296 - 3304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Severa, M. E. Remoli, E. Giacomini, J. Ragimbeau, R. Lande, G. Uze, S. Pellegrini, and E. M. Coccia Differential responsiveness to IFN-{alpha} and IFN-{beta} of human mature DC through modulation of IFNAR expression J. Leukoc. Biol., June 1, 2006; 79(6): 1286 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E M Coccia, M E Remoli, C Di Giacinto, B Del Zotto, E Giacomini, G Monteleone, and M Boirivant Cholera toxin subunit B inhibits IL-12 and IFN-{gamma} production and signaling in experimental colitis and Crohn's disease Gut, November 1, 2005; 54(11): 1558 - 1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shi, A. Blumenthal, C. M. Hickey, S. Gandotra, D. Levy, and S. Ehrt Expression of Many Immunologically Important Genes in Mycobacterium tuberculosis-Infected Macrophages Is Independent of Both TLR2 and TLR4 but Dependent on IFN-{alpha}{beta} Receptor and STAT1 J. Immunol., September 1, 2005; 175(5): 3318 - 3328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Buettner, C. Meinken, M. Bastian, R. Bhat, E. Stossel, G. Faller, G. Cianciolo, J. Ficker, M. Wagner, M. Rollinghoff, et al. Inverse Correlation of Maturity and Antibacterial Activity in Human Dendritic Cells J. Immunol., April 1, 2005; 174(7): 4203 - 4209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Prabhakar, Y. Qiao, A. Canova, D. B. Tse, and R. Pine IFN-{alpha}{beta} Secreted during Infection Is Necessary but Not Sufficient for Negative Feedback Regulation of IFN-{alpha}{beta} Signaling by Mycobacterium tuberculosis J. Immunol., January 15, 2005; 174(2): 1003 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Gauzzi, C. Purificato, K. Donato, Y. Jin, L. Wang, K. C. Daniel, A. A. Maghazachi, F. Belardelli, L. Adorini, and S. Gessani Suppressive Effect of 1{alpha},25-Dihydroxyvitamin D3 on Type I IFN-Mediated Monocyte Differentiation into Dendritic Cells: Impairment of Functional Activities and Chemotaxis J. Immunol., January 1, 2005; 174(1): 270 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Dondi, G. Roue, V. J. Yuste, S. A. Susin, and S. Pellegrini A Dual Role of IFN-{alpha} in the Balance between Proliferation and Death of Human CD4+ T Lymphocytes during Primary Response J. Immunol., September 15, 2004; 173(6): 3740 - 3747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mariotti, R. Teloni, E. Iona, L. Fattorini, G. Romagnoli, M. C. Gagliardi, G. Orefici, and R. Nisini Mycobacterium tuberculosis Diverts Alpha Interferon-Induced Monocyte Differentiation from Dendritic Cells into Immunoprivileged Macrophage-Like Host Cells Infect. Immun., August 1, 2004; 72(8): 4385 - 4392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Foster, S. H. Masri, R. David, M. Jones, A. Datta, G. Lombardi, L. Runkell, C. de Dios, I. Sizing, M. J. James, et al. IFN-{alpha} Subtypes Differentially Affect Human T Cell Motility J. Immunol., August 1, 2004; 173(3): 1663 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Yokota, N. Yokosawa, T. Okabayashi, T. Suzutani, S. Miura, K. Jimbow, and N. Fujii Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway J. Virol., June 15, 2004; 78(12): 6282 - 6286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mattner, A. Wandersee-Steinhauser, A. Pahl, M. Rollinghoff, G. R. Majeau, P. S. Hochman, and C. Bogdan Protection against Progressive Leishmaniasis by IFN-{beta} J. Immunol., June 15, 2004; 172(12): 7574 - 7582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Gold, Y. Hoshino, S. Hoshino, M. B. Jones, A. Nolan, and M. D. Weiden Exogenous Gamma and Alpha/Beta Interferon Rescues Human Macrophages from Cell Death Induced by Bacillus anthracis Infect. Immun., March 1, 2004; 72(3): 1291 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Qiao, S. Prabhakar, A. Canova, Y. Hoshino, M. Weiden, and R. Pine Posttranscriptional Inhibition of Gene Expression by Mycobacterium tuberculosis Offsets Transcriptional Synergism with IFN-{gamma} and Posttranscriptional Up-Regulation by IFN-{gamma} J. Immunol., March 1, 2004; 172(5): 2935 - 2943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chaussabel, R. T. Semnani, M. A. McDowell, D. Sacks, A. Sher, and T. B. Nutman Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites Blood, July 15, 2003; 102(2): 672 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Prabhakar, Y. Qiao, Y. Hoshino, M. Weiden, A. Canova, E. Giacomini, E. Coccia, and R. Pine Inhibition of Response to Alpha Interferon by Mycobacterium tuberculosis Infect. Immun., May 1, 2003; 71(5): 2487 - 2497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kerkmann, S. Rothenfusser, V. Hornung, A. Towarowski, M. Wagner, A. Sarris, T. Giese, S. Endres, and G. Hartmann Activation with CpG-A and CpG-B Oligonucleotides Reveals Two Distinct Regulatory Pathways of Type I IFN Synthesis in Human Plasmacytoid Dendritic Cells J. Immunol., May 1, 2003; 170(9): 4465 - 4474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lande, E. Giacomini, T. Grassi, M. E. Remoli, E. Iona, M. Miettinen, I. Julkunen, and E. M. Coccia IFN-{alpha}{beta} Released by Mycobacterium tuberculosis-Infected Human Dendritic Cells Induces the Expression of CXCL10: Selective Recruitment of NK and Activated T Cells J. Immunol., February 1, 2003; 170(3): 1174 - 1182. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
