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* Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97201;
Max von Pettenkofer Institute, Munich, Germany; and
Corixa Corporation, Seattle, Washington 98104
Although in vitro studies have shown that herpesviruses, including
murine CMV (MCMV), encode genes that interfere with the MHC class I
pathway, their effects on the CTL response in vivo is unclear. We
identified a Db-restricted CTL epitope from MCMV M45 by
screening an MCMV genomic library using CTL clones isolated from mice
infected with MCMV lacking m152. Because
m152 severely inhibits CTL recognition of M45 in vitro,
we questioned whether an M45-specific response would be generated in
mice infected with wild-type MCMV expressing m152. Mice
infected with wild-type MCMV or MCMV
m152 made similar responses to
the M45 Ag. Moreover, we saw no skewing of the proportion of
M45-specific CD8 T cells within the total MCMV-specific response after
infection with MCMV with m152. Despite the profound
effect m152 has on presentation of M45 in vitro, it does
not affect the immunodominance of M45 in the CTL response in
vivo.
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