| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114;
Massachusetts Eye and Ear Infirmary/National Eye Institute Training Program in the Molecular Bases of Eye Diseases, Massachusetts Eye and Ear Infirmary, Boston, MA 02114; and
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115
The induction of peripheral tolerance via immune privileged sites such as the eye requires splenic colocalization of NKT cells and CD1d+ tolerogenic F4/80+ APCs, both of which are needed for the generation of CD8+-regulatory T (Tr) cells. Whereas tolerogenic APCs secrete the chemokine macrophage-inflammatory protein-2 for the purpose of recruiting NKT cells, the signals responsible for recruiting potential Tr cells and additional APCs to the spleen are not known. Here we examined the ability of CD1d-stimulated NKT cells to produce chemokines that can recruit other cells needed for tolerance. Our results show that NKT cells stimulated by either CD1d-transfected fibroblasts in vitro or CD1d+ tolerogenic APCs both in vivo and ex vivo produced RANTES in a CD1d-dependent manner. The requirement for RANTES in tolerance was demonstrated by studies in which RANTES blockade in vivo prevented not only APC accumulation in the spleen but also the generation of CD8+ Tr cells that suppress Th1 immunity. Thus, CD1d-restricted NKT cells provide critical signals for orchestrating the accumulation of cells needed for tolerance induction. These data expand our current knowledge of RANTES beyond its role in Th1 immune responses to show its importance in tolerance induction and add a novel aspect to our understanding of the role of NKT cells in tolerance. Understanding the precise mechanisms involved in tolerance induction may lead to more effective therapeutic strategies for autoimmunity and graft rejection.
This article has been cited by other articles:
|
|
 |
|
  M. J. Mattapallil, A. Augello, C. Cheadle, D. Teichberg, K. G. Becker, C.-C. Chan, J. J. Mattapallil, G. Pennesi, and R. R. Caspi Differentially Expressed Genes in MHC-Compatible Rat Strains That Are Susceptible or Resistant to Experimental Autoimmune Uveitis Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 1957 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-H. Sonoda, T. Nakamura, H. A. Young, D. Hart, P. Carmeliet, and J. Stein-Streilein NKT Cell-Derived Urokinase-Type Plasminogen Activator Promotes Peripheral Tolerance Associated with Eye J. Immunol., August 15, 2007; 179(4): 2215 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Stein-Streilein and A. W. Taylor An eye's view of T regulatory cells J. Leukoc. Biol., March 1, 2007; 81(3): 593 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Ashour and J. Y. Niederkorn {gamma}{delta} T Cells Promote Anterior Chamber-Associated Immune Deviation and Immune Privilege through Their Production of IL-10 J. Immunol., December 15, 2006; 177(12): 8331 - 8337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Reyes, L. I. Terrazas, B. Espinoza, D. Cruz-Robles, V. Soto, I. Rivera-Montoya, L. Gomez-Garcia, H. Snider, A. R. Satoskar, and M. Rodriguez-Sosa Macrophage Migration Inhibitory Factor Contributes to Host Defense against Acute Trypanosoma cruzi Infection. Infect. Immun., June 1, 2006; 74(6): 3170 - 3179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Ashour and J. Y. Niederkorn Peripheral Tolerance Via the Anterior Chamber of the Eye: Role of B Cells in MHC Class I and II Antigen Presentation J. Immunol., May 15, 2006; 176(10): 5950 - 5957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nowak, F. Kopp, K. Roelofs-Haarhuis, X. Wu, and E. Gleichmann Oral nickel tolerance: fas ligand-expressing invariant NK T cells promote tolerance induction by eliciting apoptotic death of antigen-carrying, effete B cells. J. Immunol., April 15, 2006; 176(8): 4581 - 4589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Matsuda, Q. Zhang, R. Ndonye, S. K. Richardson, A. R. Howell, and L. Gapin T-bet concomitantly controls migration, survival, and effector functions during the development of V{alpha}14i NKT cells Blood, April 1, 2006; 107(7): 2797 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Faunce, J. L. Palmer, K. K. Paskowicz, P. L. Witte, and E. J. Kovacs CD1d-Restricted NKT Cells Contribute to the Age-Associated Decline of T Cell Immunity J. Immunol., September 1, 2005; 175(5): 3102 - 3109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Yue, A. Shaulov, R. Wang, S. P. Balk, and M. A. Exley CD1d ligation on human monocytes directly signals rapid NF-{kappa}B activation and production of bioactive IL-12 PNAS, August 16, 2005; 102(33): 11811 - 11816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakamura, A. Terajewicz, and J. Stein-Streilein Mechanisms of Peripheral Tolerance following Intracameral Inoculation Are Independent of IL-13 or STAT6 J. Immunol., August 15, 2005; 175(4): 2643 - 2646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kitaichi, K. Namba, and A. W. Taylor Inducible immune regulation following autoimmune disease in the immune-privileged eye J. Leukoc. Biol., April 1, 2005; 77(4): 496 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Oh, S. Kim, S.-H. Park, H. Gu, D. Roopenian, D. H. Chung, Y. S. Kim, and D.-S. Lee Direct Regulatory Role of NKT Cells in Allogeneic Graft Survival Is Dependent on the Quantitative Strength of Antigenicity J. Immunol., February 15, 2005; 174(4): 2030 - 2036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Duthie, M. Kahn, M. White, R. P. Kapur, and S. J. Kahn Critical Proinflammatory and Anti-Inflammatory Functions of Different Subsets of CD1d-Restricted Natural Killer T Cells during Trypanosoma cruzi Infection Infect. Immun., January 1, 2005; 73(1): 181 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Shibolet, Y. Kalish, A. Klein, R. Alper, L. Zolotarov, B. Thalenfeld, D. Engelhardt, E. Rabbani, and Y. Ilan Adoptive transfer of ex vivo immune-programmed NKT lymphocytes alleviates immune-mediated colitis J. Leukoc. Biol., January 1, 2004; 75(1): 76 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Teige, I. Teige, S. Lavasani, R. Bockermann, E. Mondoc, R. Holmdahl, and S. Issazadeh-Navikas CD1-Dependent Regulation of Chronic Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis J. Immunol., January 1, 2004; 172(1): 186 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Stein-Streilein Invariant NKT Cells as Initiators, Licensors, and Facilitators of the Adaptive Immune Response J. Exp. Med., December 15, 2003; 198(12): 1779 - 1783. [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Sonoda, Y. Sasa, H. Qiao, C. Tsutsumi, T. Hisatomi, S. Komiyama, T. Kubota, T. Sakamoto, Y.-I. Kawano, and T. Ishibashi Immunoregulatory Role of Ocular Macrophages: The Macrophages Produce RANTES to Suppress Experimental Autoimmune Uveitis J. Immunol., September 1, 2003; 171(5): 2652 - 2659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakamura, K.-H. Sonoda, D. E. Faunce, J. Gumperz, T. Yamamura, S. Miyake, and J. Stein-Streilein CD4+ NKT Cells, But Not Conventional CD4+ T Cells, Are Required to Generate Efferent CD8+ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site J. Immunol., August 1, 2003; 171(3): 1266 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Faunce, R. L. Gamelli, M. A. Choudhry, and E. J. Kovacs A role for CD1d-restricted NKT cells in injury-associated T cell suppression J. Leukoc. Biol., June 1, 2003; 73(6): 747 - 755. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
