The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Müllbacher, A.
Right arrow Articles by Simon, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Müllbacher, A.
Right arrow Articles by Simon, M. M.
The Journal of Immunology, 2002, 169: 145-150.
Copyright © 2002 by The American Association of Immunologists

Antigen-Dependent Release of IFN-{gamma} by Cytotoxic T Cells Up-Regulates Fas on Target Cells and Facilitates Exocytosis-Independent Specific Target Cell Lysis

Arno Müllbacher1,*, Mario Lobigs*, Ron Tha Hla*, Thao Tran{dagger}, Thomas Stehle{dagger} and Markus M. Simon{dagger}

* Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia; and {dagger} Max-Planck-Institut für Immunbiologie, Stübeweg, Freiburg, Germany

Effector cytolytic T (Tc) lymphocytes, deficient in the exocytosis-mediated pathway of target cell lysis, induce Fas on target cells and, in turn, delayed cell death and apoptosis via the Fas ligand-Fas interaction. The induction of Fas can be blocked by anti- IFN-{gamma} Abs. This Fas up-regulation on initially Fas-negative target cells is not mediated by TCR-MHC/peptide signaling per se, but by secreted IFN-{gamma} from Tc cells after Ag engagement. The Fas up-regulation by Tc cells can be mimicked by treatment of target cells with rIFN-{gamma}. Tc cells from IFN-{gamma} knockout mice do not induce Fas expression on target cells. Tc cell-mediated Fas expression on third party, bystander, target cells does not enhance their susceptibility to lysis by these nominal effector cells. The results are discussed as to the possible relevance of the phenomenon in efficiency and regulation of the Tc cell response to infections by viruses.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. Charni, J. I. Aguilo, J. Garaude, G. de Bettignies, C. Jacquet, R. A. Hipskind, D. Singer, A. Anel, and M. Villalba
ERK5 Knockdown Generates Mouse Leukemia Cells with Low MHC Class I Levels That Activate NK Cells and Block Tumorigenesis
J. Immunol., March 15, 2009; 182(6): 3398 - 3405.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. S. Woodworth, Y. Wu, and S. M. Behar
Mycobacterium tuberculosis-Specific CD8+ T Cells Require Perforin to Kill Target Cells and Provide Protection In Vivo
J. Immunol., December 15, 2008; 181(12): 8595 - 8603.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. Shrestha and M. S. Diamond
Fas Ligand Interactions Contribute to CD8+ T-Cell-Mediated Control of West Nile Virus Infection in the Central Nervous System
J. Virol., November 1, 2007; 81(21): 11749 - 11757.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
Y. Wang, M. Lobigs, E. Lee, A. Koskinen, and A. Mullbacher
CD8+ T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon
J. Gen. Virol., December 1, 2006; 87(12): 3599 - 3609.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. K. Ahn, H. Chung, D.-s. Lee, Y. S. Yu, and H. G. Yu
CD8brightCD56+ T Cells Are Cytotoxic Effectors in Patients with Active Behcet's Uveitis
J. Immunol., November 1, 2005; 175(9): 6133 - 6142.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. C. Morris, A. Tsallios, G. M. Bendle, S.-a. Xue, and H. J. Stauss
A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection
PNAS, May 31, 2005; 102(22): 7934 - 7939.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
U. Christen, R. Darwiche, H. E. Thomas, T. Wolfe, E. Rodrigo, A. Chervonsky, R. A. Flavell, and M. G. von Herrath
Virally Induced Inflammation Triggers Fratricide of Fas-Ligand-Expressing {beta}-Cells
Diabetes, March 1, 2004; 53(3): 591 - 596.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Roth and H. Pircher
IFN-{gamma} Promotes Fas Ligand- and Perforin-Mediated Liver Cell Destruction by Cytotoxic CD8 T Cells
J. Immunol., February 1, 2004; 172(3): 1588 - 1594.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. Zamiri, Q. Zhang, and J. W. Streilein
Vulnerability of Allogeneic Retinal Pigment Epithelium to Immune T-Cell-Mediated Damage In Vivo and In Vitro
Invest. Ophthalmol. Vis. Sci., January 1, 2004; 45(1): 177 - 184.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
B.-G. Xiao, X.-C. Wu, J.-S. Yang, L.-Y. Xu, X. Liu, Y.-M. Huang, B. Bjelke, and H. Link
Therapeutic potential of IFN-{gamma}-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis
Int. Immunol., January 1, 2004; 16(1): 13 - 22.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Murakami, A. R. Cardones, S. E. Finkelstein, N. P. Restifo, B. A. Klaunberg, F. O. Nestle, S. S. Castillo, P. A. Dennis, and S. T. Hwang
Immune Evasion by Murine Melanoma Mediated through CC Chemokine Receptor-10
J. Exp. Med., November 3, 2003; 198(9): 1337 - 1347.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.