| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cutting Edge |
* Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;
Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation, Osaka, Japan;
Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030; and
Division of Dermatology, Department of Microbiology and Immunology and Molecular Biology Institute, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095
The Toll-like receptor (TLR) family acts as pattern recognition
receptors for pathogen-specific molecular patterns (PAMPs). TLR2 is
essential for the signaling of a variety of PAMPs, including bacterial
lipoprotein/lipopeptides, peptidoglycan, and GPI anchors. TLR6
associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide
along with TLR2. We report here that TLR1 associates with TLR2 and
recognizes the native mycobacterial 19-kDa lipoprotein along with TLR2.
Macrophages from TLR1-deficient (TLR1-/-) mice showed
impaired proinflammatory cytokine production in response to the 19-kDa
lipoprotein and a synthetic triacylated lipopeptide. In contrast,
TLR1-/- cells responded normally to diacylated
lipopeptide. TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2
enhanced the NF-
B activation in response to a synthetic lipopeptide.
Furthermore, lipoprotein analogs whose acylation was modified were
preferentially recognized
by
TLR1. Taken together, TLR1 interacts with TLR2 to recognize the lipid
configuration of the native mycobacterial lipoprotein as well as
several triacylated lipopeptides.
This article has been cited by other articles:
|
|
 |
|
  P. E. Almeida, A. R. Silva, C. M. Maya-Monteiro, D. Torocsik, H. D'Avila, B. Dezso, K. G. Magalhaes, H. C. Castro-Faria-Neto, L. Nagy, and P. T. Bozza Mycobacterium bovis Bacillus Calmette-Guerin Infection Induces TLR2-Dependent Peroxisome Proliferator-Activated Receptor {gamma} Expression and Activation: Functions in Inflammation, Lipid Metabolism, and Pathogenesis J. Immunol., July 15, 2009; 183(2): 1337 - 1345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-C. Raby, E. Le Bouder, C. Colmont, J. Davies, P. Richards, B. Coles, C. H. George, S. A. Jones, P. Brennan, N. Topley, et al. Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering J. Immunol., July 1, 2009; 183(1): 506 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-L. Wu, I. N. Buhtoiarov, P. M. Sondel, A. L. Rakhmilevich, and E. A. Ranheim Tumoricidal Effects of Activated Macrophages in a Mouse Model of Chronic Lymphocytic Leukemia J. Immunol., June 1, 2009; 182(11): 6771 - 6778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Covacu, L. Arvidsson, A. Andersson, M. Khademi, H. Erlandsson-Harris, R. A. Harris, M. A. Svensson, T. Olsson, and L. Brundin TLR Activation Induces TNF-{alpha} Production from Adult Neural Stem/Progenitor Cells J. Immunol., June 1, 2009; 182(11): 6889 - 6895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kurokawa, H. Lee, K.-B. Roh, M. Asanuma, Y. S. Kim, H. Nakayama, A. Shiratsuchi, Y. Choi, O. Takeuchi, H. J. Kang, et al. The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2 J. Biol. Chem., March 27, 2009; 284(13): 8406 - 8411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Cerovic, C. D. Jenkins, A. G. C. Barnes, S. W. F. Milling, G. G. MacPherson, and L. S. Klavinskis Hyporesponsiveness of Intestinal Dendritic Cells to TLR Stimulation Is Limited to TLR4 J. Immunol., February 15, 2009; 182(4): 2405 - 2415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Blair, S. Rex, O. Vitseva, L. Beaulieu, K. Tanriverdi, S. Chakrabarti, C. Hayashi, C. A. Genco, M. Iafrati, and J. E. Freedman Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase Circ. Res., February 13, 2009; 104(3): 346 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Gargano, J. C. Forrest, and S. H. Speck Signaling through Toll-Like Receptors Induces Murine Gammaherpesvirus 68 Reactivation In Vivo J. Virol., February 1, 2009; 83(3): 1474 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Gomez, C. L. Arguelles, D. Guerrieri, N. L. Tateosian, N. O. Amiano, R. Slimovich, P. C. Maffia, E. Abbate, R. M. Musella, V. E. Garcia, et al. Secretory Leukocyte Protease Inhibitor: A Secreted Pattern Recognition Receptor for Mycobacteria Am. J. Respir. Crit. Care Med., February 1, 2009; 179(3): 247 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sweet, W. Zhang, H. Torres-Fewell, A. Serianni, W. Boggess, and J. Schorey Mycobacterium avium Glycopeptidolipids Require Specific Acetylation and Methylation Patterns for Signaling through Toll-like Receptor 2 J. Biol. Chem., November 28, 2008; 283(48): 33221 - 33231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kiyokawa, S. Akashi-Takamura, T. Shibata, F. Matsumoto, C. Nishitani, Y. Kuroki, Y. Seto, and K. Miyake A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors Int. Immunol., November 1, 2008; 20(11): 1407 - 1415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Dasu, S. Devaraj, L. Zhao, D. H. Hwang, and I. Jialal High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation Diabetes, November 1, 2008; 57(11): 3090 - 3098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. F. Bernardino, T. A. Myers, X. Alvarez, A. Hasegawa, and M. T. Philipp Toll-Like Receptors: Insights into Their Possible Role in the Pathogenesis of Lyme Neuroborreliosis Infect. Immun., October 1, 2008; 76(10): 4385 - 4395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miettinen, V. Veckman, S. Latvala, T. Sareneva, S. Matikainen, and I. Julkunen Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages J. Leukoc. Biol., October 1, 2008; 84(4): 1092 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Wurfel, A. C. Gordon, T. D. Holden, F. Radella, J. Strout, O. Kajikawa, J. T. Ruzinski, G. Rona, R. A. Black, S. Stratton, et al. Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis Am. J. Respir. Crit. Care Med., October 1, 2008; 178(7): 710 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wu, H. Wang, W. Xiong, S. Chen, H. Tang, and D. Han Expression Patterns and Functions of Toll-Like Receptors in Mouse Sertoli Cells Endocrinology, September 1, 2008; 149(9): 4402 - 4412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Q. Nicol, J.-M. Mathys, A. Pereira, K. Ollington, M. H. Ieong, and P. R. Skolnik Human Immunodeficiency Virus Infection Alters Tumor Necrosis Factor Alpha Production via Toll-Like Receptor-Dependent Pathways in Alveolar Macrophages and U1 Cells J. Virol., August 15, 2008; 82(16): 7790 - 7798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimizu, Y. Kida, and K. Kuwano A Triacylated Lipoprotein from Mycoplasma genitalium Activates NF-{kappa}B through Toll-Like Receptor 1 (TLR1) and TLR2 Infect. Immun., August 1, 2008; 76(8): 3672 - 3678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Nilsen, S. Deininger, U. Nonstad, F. Skjeldal, H. Husebye, D. Rodionov, S. von Aulock, T. Hartung, E. Lien, O. Bakke, et al. Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36 J. Leukoc. Biol., July 1, 2008; 84(1): 280 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nigou, T. Vasselon, A. Ray, P. Constant, M. Gilleron, G. S. Besra, I. Sutcliffe, G. Tiraby, and G. Puzo Mannan Chain Length Controls Lipoglycans Signaling via and Binding to TLR2 J. Immunol., May 15, 2008; 180(10): 6696 - 6702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shimizu, Y. Kida, and K. Kuwano Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6 Microbiology, May 1, 2008; 154(5): 1318 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Trott, E. M. Hellestad, M. Yang, and M. E. Cook Additions of Killed Whole Cell Bacteria Preparations to Freund Complete Adjuvant Alter Laying Hen Antibody Response to Soluble Protein Antigen Poult. Sci., May 1, 2008; 87(5): 912 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Peiser, J. Koeck, C. J. Kirschning, B. Wittig, and R. Wanner Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity J. Leukoc. Biol., May 1, 2008; 83(5): 1118 - 1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Abrahams, P. B. Aldo, S. P. Murphy, I. Visintin, K. Koga, G. Wilson, R. Romero, S. Sharma, and G. Mor TLR6 Modulates First Trimester Trophoblast Responses to Peptidoglycan J. Immunol., May 1, 2008; 180(9): 6035 - 6043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Henneke, S. Dramsi, G. Mancuso, K. Chraibi, E. Pellegrini, C. Theilacker, J. Hubner, S. Santos-Sierra, G. Teti, D. T. Golenbock, et al. Lipoproteins Are Critical TLR2 Activating Toxins in Group B Streptococcal Sepsis J. Immunol., May 1, 2008; 180(9): 6149 - 6158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. de Paiva, A. Nobrega, G. O. De Melo, E. A. Hayashi, V. Carvalho, P. M. Rodrigues e Silva, M. Bellio, G. P. Teixeira, V. Rumjanek, S. S. Costa, et al. Selective blockade of lymphopoiesis induced by kalanchosine dimalate: inhibition of IL-7-dependent proliferation J. Leukoc. Biol., April 1, 2008; 83(4): 1038 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Farhat, S. Riekenberg, H. Heine, J. Debarry, R. Lang, J. Mages, U. Buwitt-Beckmann, K. Roschmann, G. Jung, K.-H. Wiesmuller, et al. Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling J. Leukoc. Biol., March 1, 2008; 83(3): 692 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pegu, S. Qin, B. A. Fallert Junecko, R. E. Nisato, M. S. Pepper, and T. A. Reinhart Human Lymphatic Endothelial Cells Express Multiple Functional TLRs J. Immunol., March 1, 2008; 180(5): 3399 - 3405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Thakran, H. Li, C. L. Lavine, M. A. Miller, J. E. Bina, X. R. Bina, and F. Re Identification of Francisella tularensis Lipoproteins That Stimulate the Toll-like Receptor (TLR) 2/TLR1 Heterodimer J. Biol. Chem., February 15, 2008; 283(7): 3751 - 3760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Yang, Q. Chen, S. B. Su, P. Zhang, K. Kurosaka, R. R. Caspi, S. M. Michalek, H. F. Rosenberg, N. Zhang, and J. J. Oppenheim Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses J. Exp. Med., January 21, 2008; 205(1): 79 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bas, L. Neff, M. Vuillet, U. Spenato, T. Seya, M. Matsumoto, and C. Gabay The Proinflammatory Cytokine Response to Chlamydia trachomatis Elementary Bodies in Human Macrophages Is Partly Mediated by a Lipoprotein, the Macrophage Infectivity Potentiator, through TLR2/TLR1/TLR6 and CD14 J. Immunol., January 15, 2008; 180(2): 1158 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimizu, Y. Kida, and K. Kuwano Mycoplasma pneumoniae-Derived Lipopeptides Induce Acute Inflammatory Responses in the Lungs of Mice Infect. Immun., January 1, 2008; 76(1): 270 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ruby, K. Rehani, and M. Martin Treponema denticola Activates Mitogen-Activated Protein Kinase Signal Pathways through Toll-Like Receptor 2 Infect. Immun., December 1, 2007; 75(12): 5763 - 5768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhou and S. Amar Identification of Signaling Pathways in Macrophage Exposed to Porphyromonas gingivalis or to Its Purified Cell Wall Components J. Immunol., December 1, 2007; 179(11): 7777 - 7790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Murphy, H. J. Legere III, and H. R. Katz Activation of Protein Kinase D1 in Mast Cells in Response to Innate, Adaptive, and Growth Factor Signals J. Immunol., December 1, 2007; 179(11): 7876 - 7882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takahashi, T. Shibata, S. Akashi-Takamura, T. Kiyokawa, Y. Wakabayashi, N. Tanimura, T. Kobayashi, F. Matsumoto, R. Fukui, T. Kouro, et al. A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses J. Exp. Med., November 26, 2007; 204(12): 2963 - 2976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Tonks, E. Dudley, N. G. Porter, J. Parton, J. Brazier, E. L. Smith, and A. Tonks A 5.8-kDa component of manuka honey stimulates immune cells via TLR4 J. Leukoc. Biol., November 1, 2007; 82(5): 1147 - 1155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Geisel, F. Kahl, M. Muller, H. Wagner, C. J. Kirschning, I. B. Autenrieth, and J.-S. Frick IL-6 and Maturation Govern TLR2 and TLR4 Induced TLR Agonist Tolerance and Cross-Tolerance in Dendritic Cells J. Immunol., November 1, 2007; 179(9): 5811 - 5818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, M. J. Cowan, J. D. Hasday, S. N. Vogel, and A. E. Medvedev Tobacco Smoking Inhibits Expression of Proinflammatory Cytokines and Activation of IL-1R-Associated Kinase, p38, and NF-{kappa}B in Alveolar Macrophages Stimulated with TLR2 and TLR4 Agonists J. Immunol., November 1, 2007; 179(9): 6097 - 6106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bhatnagar, K. Shinagawa, F. J. Castellino, and J. S. Schorey Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo Blood, November 1, 2007; 110(9): 3234 - 3244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-C. Chen, E. Giovannucci, P. Kraft, R. Lazarus, and D. J. Hunter Association between Toll-Like Receptor Gene Cluster (TLR6, TLR1, and TLR10) and Prostate Cancer Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1982 - 1989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Thibault, M. R. Tardif, C. Barat, and M. J. Tremblay TLR2 Signaling Renders Quiescent Naive and Memory CD4+ T Cells More Susceptible to Productive Infection with X4 and R5 HIV-Type 1 J. Immunol., October 1, 2007; 179(7): 4357 - 4366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Young Goo, Y. S. Han, W. H. Kim, K.-H. Lee, and S.-J. Park Vibrio vulnificus IlpA-induced Cytokine Production Is Mediated by Toll-like Receptor 2 J. Biol. Chem., September 21, 2007; 282(38): 27647 - 27658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vallois, C. H. Grimm, P. Avner, C. Boitard, and U. C. Rogner The Type 1 Diabetes Locus Idd6 Controls TLR1 Expression J. Immunol., September 15, 2007; 179(6): 3896 - 3903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. MacLeod and L. M. Wetzler T Cell Activation by TLRs: A Role for TLRs in the Adaptive Immune Response Sci. Signal., September 4, 2007; 2007(402): pe48 - pe48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Fremond, D. Togbe, E. Doz, S. Rose, V. Vasseur, I. Maillet, M. Jacobs, B. Ryffel, and V. F. J. Quesniaux IL-1 Receptor-Mediated Signal Is an Essential Component of MyD88-Dependent Innate Response to Mycobacterium tuberculosis Infection J. Immunol., July 15, 2007; 179(2): 1178 - 1189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Dye, A. Palvanov, B. Guo, and T. L. Rothstein B Cell Receptor Cross-Talk: Exposure to Lipopolysaccharide Induces an Alternate Pathway for B Cell Receptor-Induced ERK Phosphorylation and NF-{kappa}B Activation J. Immunol., July 1, 2007; 179(1): 229 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Johnson, E. A. Lyle, K. O. Omueti, V. A. Stepensky, O. Yegin, E. Alpsoy, L. Hamann, R. R. Schumann, and R. I. Tapping Cutting Edge: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects against Leprosy J. Immunol., June 15, 2007; 178(12): 7520 - 7524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A Mitchell, M. J Paul-Clark, G. W Clarke, S. K McMaster, and N. Cartwright Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease J. Endocrinol., June 1, 2007; 193(3): 323 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Imanishi, H. Hara, S. Suzuki, N. Suzuki, S. Akira, and T. Saito Cutting Edge: TLR2 Directly Triggers Th1 Effector Functions J. Immunol., June 1, 2007; 178(11): 6715 - 6719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Keestra, M. R. de Zoete, R. A. M. H. van Aubel, and J. P. M. van Putten The Central Leucine-Rich Repeat Region of Chicken TLR16 Dictates Unique Ligand Specificity and Species-Specific Interaction with TLR2 J. Immunol., June 1, 2007; 178(11): 7110 - 7119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. O. Omueti, D. J. Mazur, K. S. Thompson, E. A. Lyle, and R. I. Tapping The Polymorphism P315L of Human Toll-Like Receptor 1 Impairs Innate Immune Sensing of Microbial Cell Wall Components J. Immunol., May 15, 2007; 178(10): 6387 - 6394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Hoffmann, J. S. Braun, D. Becker, A. Halle, D. Freyer, E. Dagand, S. Lehnardt, and J. R. Weber TLR2 Mediates Neuroinflammation and Neuronal Damage J. Immunol., May 15, 2007; 178(10): 6476 - 6481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Into, J.-i. Dohkan, M. Inomata, M. Nakashima, K.-i. Shibata, and K. Matsushita Synthesis and Characterization of a Dipalmitoylated Lipopeptide Derived from Paralogous Lipoproteins of Mycoplasma pneumoniae Infect. Immun., May 1, 2007; 75(5): 2253 - 2259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Togbe, L. Schofield, G. E. Grau, B. Schnyder, V. Boissay, S. Charron, S. Rose, B. Beutler, V. F.J. Quesniaux, and B. Ryffel Murine Cerebral Malaria Development Is Independent of Toll-Like Receptor Signaling Am. J. Pathol., May 1, 2007; 170(5): 1640 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hashimoto, M. Furuyashiki, R. Kaseya, Y. Fukada, M. Akimaru, K. Aoyama, T. Okuno, T. Tamura, T. Kirikae, F. Kirikae, et al. Evidence of Immunostimulating Lipoprotein Existing in the Natural Lipoteichoic Acid Fraction Infect. Immun., April 1, 2007; 75(4): 1926 - 1932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Asai, Y. Makimura, and T. Ogawa Toll-like receptor 2-mediated dendritic cell activation by a Porphyromonas gingivalis synthetic lipopeptide J. Med. Microbiol., April 1, 2007; 56(4): 459 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kielian, N. K. Phulwani, N. Esen, M. Md. Syed, A. C. Haney, K. McCastlain, and J. Johnson MyD88-Dependent Signals Are Essential for the Host Immune Response in Experimental Brain Abscess J. Immunol., April 1, 2007; 178(7): 4528 - 4537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Alugupalli, S. Akira, E. Lien, and J. M. Leong MyD88- and Bruton's Tyrosine Kinase-Mediated Signals Are Essential for T Cell-Independent Pathogen-Specific IgM Responses J. Immunol., March 15, 2007; 178(6): 3740 - 3749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Liang, M. Wang, R. I. Tapping, V. Stepensky, H. F. Nawar, M. Triantafilou, K. Triantafilou, T. D. Connell, and G. Hajishengallis Ganglioside GD1a Is an Essential Coreceptor for Toll-like Receptor 2 Signaling in Response to the B subunit of Type IIb Enterotoxin J. Biol. Chem., March 9, 2007; 282(10): 7532 - 7542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hamm, A. Heit, M. Koffler, K. M. Huster, S. Akira, D. H. Busch, H. Wagner, and S. Bauer Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo Int. Immunol., March 1, 2007; 19(3): 297 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Y. Toshchakov, M. J. Fenton, and S. N. Vogel Cutting Edge: Differential Inhibition of TLR Signaling Pathways by Cell-Permeable Peptides Representing BB Loops of TLRs J. Immunol., March 1, 2007; 178(5): 2655 - 2660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wiens, M. Korzhev, S. Perovic-Ottstadt, B. Luthringer, D. Brandt, S. Klein, and W. E. G. Muller Toll-Like Receptors Are Part of the Innate Immune Defense System of Sponges (Demospongiae: Porifera) Mol. Biol. Evol., March 1, 2007; 24(3): 792 - 804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pevsner-Fischer, V. Morad, M. Cohen-Sfady, L. Rousso-Noori, A. Zanin-Zhorov, S. Cohen, I. R. Cohen, and D. Zipori Toll-like receptors and their ligands control mesenchymal stem cell functions Blood, February 15, 2007; 109(4): 1422 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Satta, S. Dunoyer-Geindre, G. Reber, R. J. Fish, F. Boehlen, E. K. O. Kruithof, and P. de Moerloose The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies Blood, February 15, 2007; 109(4): 1507 - 1514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-F. Tsan and Baochong Gao Review: Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors Innate Immunity, February 1, 2007; 13(1): 6 - 14. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Aflatoonian, E. Tuckerman, S.L. Elliott, C. Bruce, A. Aflatoonian, T.C. Li, and A. Fazeli Menstrual cycle-dependent changes of Toll-like receptors in endometrium Hum. Reprod., February 1, 2007; 22(2): 586 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. van Duin, S. Mohanty, V. Thomas, S. Ginter, R. R. Montgomery, E. Fikrig, H. G. Allore, R. Medzhitov, and A. C. Shaw Age-Associated Defect in Human TLR-1/2 Function J. Immunol., January 15, 2007; 178(2): 970 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bagchi, E. A. Herrup, H. S. Warren, J. Trigilio, H.-S. Shin, C. Valentine, and J. Hellman MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists J. Immunol., January 15, 2007; 178(2): 1164 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Erridge, C. M. Spickett, and D. J. Webb Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2 Cardiovasc Res, January 1, 2007; 73(1): 181 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, Y. Shao, T. A. Bennett, R. A. Shankar, P. D. Wightman, and L. G. Reddy The Functional Effects of Physical Interactions among Toll-like Receptors 7, 8, and 9 J. Biol. Chem., December 8, 2006; 281(49): 37427 - 37434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Bolz, R. S. Sundsbak, Y. Ma, S. Akira, J. H. Weis, T. G. Schwan, and J. J. Weis Dual Role of MyD88 in Rapid Clearance of Relapsing Fever Borrelia spp. Infect. Immun., December 1, 2006; 74(12): 6750 - 6760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Flacher, M. Bouschbacher, E. Verronese, C. Massacrier, V. Sisirak, O. Berthier-Vergnes, B. de Saint-Vis, C. Caux, C. Dezutter-Dambuyant, S. Lebecque, et al. Human Langerhans Cells Express a Specific TLR Profile and Differentially Respond to Viruses and Gram-Positive Bacteria J. Immunol., December 1, 2006; 177(11): 7959 - 7967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. F. Lau, G. Deliyannis, W. Zeng, A. Mansell, D. C. Jackson, and L. E. Brown Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines Int. Immunol., December 1, 2006; 18(12): 1801 - 1813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Triantafilou, F. G. J. Gamper, R. M. Haston, M. A. Mouratis, S. Morath, T. Hartung, and K. Triantafilou Membrane Sorting of Toll-like Receptor (TLR)-2/6 and TLR2/1 Heterodimers at the Cell Surface Determines Heterotypic Associations with CD36 and Intracellular Targeting J. Biol. Chem., October 13, 2006; 281(41): 31002 - 31011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, S. Nookala, X. R. Bina, J. E. Bina, and F. Re Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation J. Leukoc. Biol., October 1, 2006; 80(4): 766 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hashimoto, K. Tawaratsumida, H. Kariya, A. Kiyohara, Y. Suda, F. Krikae, T. Kirikae, and F. Gotz Not Lipoteichoic Acid but Lipoproteins Appear to Be the Dominant Immunobiologically Active Compounds in Staphylococcus aureus. J. Immunol., September 1, 2006; 177(5): 3162 - 3169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Miyake Invited review: Roles for accessory molecules in microbial recognition by Toll-like receptors Innate Immunity, August 1, 2006; 12(4): 195 - 204. [Abstract] [PDF]
|
|
|
|
|
|
A. Punturieri, P. Copper, T. Polak, P. J. Christensen, and J. L. Curtis Conserved Nontypeable Haemophilus influenzae-Derived TLR2-Binding Lipopeptides Synergize with IFN-beta to Increase Cytokine Production by Resident Murine and Human Alveolar Macrophages J. Immunol., July 1, 2006; 177(1): 673 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Arcaroli, E. Silva, J. P. Maloney, Q. He, D. Svetkauskaite, J. R. Murphy, and E. Abraham Variant IRAK-1 Haplotype Is Associated with Increased Nuclear Factor-{kappa}B Activation and Worse Outcomes in Sepsis Am. J. Respir. Crit. Care Med., June 15, 2006; 173(12): 1335 - 1341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Henneke and R. Berner Interaction of neonatal phagocytes with group B streptococcus: recognition and response. Infect. Immun., June 1, 2006; 74(6): 3085 - 3095. [Full Text] [PDF]
|
|
|
|
|
|
M. Shi and J. Xiang CD4+ T cell-independent maintenance and expansion of memory CD8+ T cells derived from in vitro dendritic cell activation Int. Immunol., June 1, 2006; 18(6): 887 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Esen and T. Kielian Central Role for MyD88 in the Responses of Microglia to Pathogen-Associated Molecular Patterns. J. Immunol., June 1, 2006; 176(11): 6802 - 6811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Buwitt-Beckmann, H. Heine, K.-H. Wiesmuller, G. Jung, R. Brock, S. Akira, and A. J. Ulmer TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides J. Biol. Chem., April 7, 2006; 281(14): 9049 - 9057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-S. X. Yu and L. D. Hazlett Toll-like Receptors and the Eye. Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1255 - 1263. [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Liu and A. B. Malik NF-{kappa}B activation as a pathological mechanism of septic shock and inflammation Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L622 - L645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Basler, S. Jeckstadt, P. Valentin-Weigand, and R. Goethe Mycobacterium paratuberculosis, Mycobacterium smegmatis, and lipopolysaccharide induce different transcriptional and post-transcriptional regulation of the IRG1 gene in murine macrophages J. Leukoc. Biol., March 1, 2006; 79(3): 628 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Chang, J. F. Huggett, K. Dheda, L. U. Kim, A. Zumla, and G. A. W. Rook Myobacterium tuberculosis Induces Selective Up-Regulation of TLRs in the Mononuclear Leukocytes of Patients with Active Pulmonary Tuberculosis. J. Immunol., March 1, 2006; 176(5): 3010 - 3018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Banaiee, E. Z. Kincaid, U. Buchwald, W. R. Jacobs Jr., and J. D. Ernst Potent Inhibition of Macrophage Responses to IFN-{gamma} by Live Virulent Mycobacterium tuberculosis Is Independent of Mature Mycobacterial Lipoproteins but Dependent on TLR2. J. Immunol., March 1, 2006; 176(5): 3019 - 3027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D'Avila, R. C. N. Melo, G. G. Parreira, E. Werneck-Barroso, H. C. Castro-Faria-Neto, and P. T. Bozza Mycobacterium bovis Bacillus Calmette-Guerin Induces TLR2-Mediated Formation of Lipid Bodies: Intracellular Domains for Eicosanoid Synthesis In Vivo. J. Immunol., March 1, 2006; 176(5): 3087 - 3097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Massari, A. Visintin, J. Gunawardana, K. A. Halmen, C. A. King, D. T. Golenbock, and L. M. Wetzler Meningococcal Porin PorB Binds to TLR2 and Requires TLR1 for Signaling J. Immunol., February 15, 2006; 176(4): 2373 - 2380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hashimoto, K. Tawaratsumida, H. Kariya, K. Aoyama, T. Tamura, and Y. Suda Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components Int. Immunol., February 1, 2006; 18(2): 355 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. O'Connell, I. A. Ionova, A. J. Quayle, A. Visintin, and R. R. Ingalls Localization of TLR2 and MyD88 to Chlamydia trachomatis Inclusions: EVIDENCE FOR SIGNALING BY INTRACELLULAR TLR2 DURING INFECTION WITH AN OBLIGATE INTRACELLULAR PATHOGEN J. Biol. Chem., January 20, 2006; 281(3): 1652 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Vermi, F. Facchetti, E. Riboldi, H. Heine, S. Scutera, S. Stornello, D. Ravarino, P. Cappello, M. Giovarelli, R. Badolato, et al. Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma Blood, January 15, 2006; 107(2): 454 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Fritz and S. E. Girardin How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals Innate Immunity, December 1, 2005; 11(6): 390 - 394. [Abstract] [PDF]
|
|
|
|
|
|
K. O. Omueti, J. M. Beyer, C. M. Johnson, E. A. Lyle, and R. I. Tapping Domain Exchange between Human Toll-like Receptors 1 and 6 Reveals a Region Required for Lipopeptide Discrimination J. Biol. Chem., November 4, 2005; 280(44): 36616 - 36625. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
