| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cutting Edge |
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110
We have quantitated the major families of peptides from hen egg lysozyme (HEL) presented by MHC class II I-Ak molecules. One striking feature is that the four epitopes are presented at levels that differ by as much as 200- to 300-fold. In these studies, we describe the CD4+ T cell response to each epitope after immunization with several doses of hen egg lysozyme protein. Although fewer T cells were generated at lower doses, the surprising finding was the responses to all four peptides were maintained. The relative number of T cell clones to each of the four epitopes was influenced to a very limited degree by their levels of presentation at the lowest dose. In conclusion, under strong stimulatory conditions, there is not a direct relationship between levels of peptide presentation and the T cell responses.
This article has been cited by other articles:
|
|
 |
|
  S. B. Lovitch, T. J. Esparza, G. Schweitzer, J. Herzog, and E. R. Unanue Activation of Type B T Cells after Protein Immunization Reveals Novel Pathways of In Vivo Presentation of Peptides J. Immunol., January 1, 2007; 178(1): 122 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Willis, J. W. Kappler, and P. C. Marrack CD8 T cell competition for dendritic cells in vivo is an early event in activation PNAS, August 8, 2006; 103(32): 12063 - 12068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ireland, J. Herzog, and E. R. Unanue Cutting Edge: Unique T Cells That Recognize Citrullinated Peptides Are a Feature of Protein Immunization J. Immunol., August 1, 2006; 177(3): 1421 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Herzog, Y. Maekawa, T. P. Cirrito, B. S. Illian, and E. R. Unanue Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells PNAS, May 31, 2005; 102(22): 7928 - 7933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Byersdorfer, R. J. DiPaolo, S. J. Petzold, and E. R. Unanue Following Immunization Antigen Becomes Concentrated in a Limited Number of APCs Including B Cells J. Immunol., December 1, 2004; 173(11): 6627 - 6634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P. Yeung, J. Chang, J. Miller, C. Barnett, M. Stickler, and F. A. Harding Elimination of an Immunodominant CD4+ T Cell Epitope in Human IFN-{beta} Does Not Result in an In Vivo Response Directed at the Subdominant Epitope J. Immunol., June 1, 2004; 172(11): 6658 - 6665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bielekova, M.-H. Sung, N. Kadom, R. Simon, H. McFarland, and R. Martin Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis J. Immunol., March 15, 2004; 172(6): 3893 - 3904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. N. Toka, M. Gierynska, and B. T. Rouse Codelivery of CCR7 Ligands as Molecular Adjuvants Enhances the Protective Immune Response against Herpes Simplex Virus Type 1 J. Virol., December 1, 2003; 77(23): 12742 - 12752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. DiPaolo and E. R. Unanue Cutting Edge: The Relative Distribution of T Cells Responding to Chemically Dominant or Minor Epitopes of Lysozyme Is Not Affected by CD40-CD40 Ligand and B7-CD28-CTLA-4 Costimulatory Pathways J. Immunol., September 15, 2002; 169(6): 2832 - 2836. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
