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RI 
-Chain Gene Expression by Multiple Transcription Factors
* Allergy (Atopy) Research Center, Departments of
Immunology and
Dermatology, Juntendo University School of Medicine, Tokyo, Japan;
Biotechnology Research Center, University of Tokyo, Tokyo, Japan; and
¶ Foods and Pharmaceuticals Research and Development Laboratory, Asahi Breweries, Ibaraki, Japan
Transcriptional regulation of the gene-encoding human Fc
RI
-chain was analyzed in detail. EMSA revealed that either YY1 or PU.1
bound to the region close to that recognized by Elf-1. The -chain
promoter activity was up-regulated 
2-fold by exogenously expressed
YY1 or PU.1 and 7-fold by GATA-1, respectively, in KU812 cells. In
contrast, coexpression of GATA-1 with either of PU.1 or YY1
dramatically activated the promoter 41- or 27-fold, respectively.
Especially synergic activation by GATA-1 and PU.1 was surprising,
because these transcription factors are known to inhibit the respective
transactivating activities of each other. These up-regulating effects
of PU.1 and YY1 with GATA-1 were inhibited by overexpression of Elf-1,
indicating that Elf-1 serves as a repressor for the -chain gene
expression. Transcriptional regulation of the -chain gene through
four transcriptional factors is discussed.
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