The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by von Essen, M.
Right arrow Articles by Geisler, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by von Essen, M.
Right arrow Articles by Geisler, C.
The Journal of Immunology, 2002, 168: 4519-4523.
Copyright © 2002 by The American Association of Immunologists

The CD3{gamma} Leucine-Based Receptor-Sorting Motif Is Required for Efficient Ligand-Mediated TCR Down-Regulation1

Marina von Essen, Charlotte Menné, Bodil L. Nielsen, Jens Peter H. Lauritsen, Jes Dietrich, Peter S. Andersen, Klaus Karjalainen, Niels Ødum and Carsten Geisler2

Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark

TCR down-regulation plays an important role in modulating T cell responses both during T cell development and in mature T cells. At least two distinct pathways exist for down-regulation of the TCR. One pathway is activated following TCR ligation and is dependent on tyrosine phosphorylation. The other pathway is dependent on protein kinase C (PKC)-mediated activation of the CD3{gamma} di-leucine-based receptor-sorting motif. Previous studies have failed to demonstrate a connection between ligand- and PKC-induced TCR down-regulation. Thus, although an apparent paradox, the dogma has been that ligand- and PKC-induced TCR down-regulations are not interrelated. By analyses of a newly developed CD3{gamma}-negative T cell variant, freshly isolated and PHA-activated PBMC, and a mouse T cell line, we challenged this dogma and demonstrate in this work that PKC activation and the CD3{gamma} di-leucine-based motif are indeed required for efficient ligand-induced TCR down-regulation.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
L. Boding, C. M. Bonefeld, B. L. Nielsen, J. P. H. Lauritsen, M. R. von Essen, A. K. Hansen, J. M. Larsen, M. M. Nielsen, N. Odum, and C. Geisler
TCR Down-Regulation Controls T Cell Homeostasis
J. Immunol., October 15, 2009; 183(8): 4994 - 5005.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. D. Schneider, A. A. Weiss, and W. E. Miller
Pertussis Toxin Signals through the TCR to Initiate Cross-Desensitization of the Chemokine Receptor CXCR4
J. Immunol., May 1, 2009; 182(9): 5730 - 5739.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. Bonefeld, M. Haks, B. Nielsen, M. von Essen, L. Boding, A. K. Hansen, J. M. Larsen, N. Odum, P. Krimpenfort, A. Kruisbeek, et al.
TCR Down-Regulation Controls Virus-Specific CD8+ T Cell Responses
J. Immunol., December 1, 2008; 181(11): 7786 - 7799.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. L. Szymczak and D. A. A. Vignali
Plasticity and Rigidity in Adaptor Protein-2-Mediated Internalization of the TCR:CD3 Complex
J. Immunol., April 1, 2005; 174(7): 4153 - 4160.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. C. Wreden, M. Wlizla, and R. J. Reimer
Varied Mechanisms Underlie the Free Sialic Acid Storage Disorders
J. Biol. Chem., January 14, 2005; 280(2): 1408 - 1416.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. von Essen, C. M. Bonefeld, V. Siersma, A. B. Rasmussen, J. P. H. Lauritsen, B. L. Nielsen, and C. Geisler
Constitutive and Ligand-Induced TCR Degradation
J. Immunol., July 1, 2004; 173(1): 384 - 393.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Nguyen, I. Moisini, and T. L. Geiger
Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function
Blood, December 15, 2003; 102(13): 4320 - 4325.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. Bonefeld, A. B. Rasmussen, J. P. H. Lauritsen, M. von Essen, N. Odum, P. S. Andersen, and C. Geisler
TCR Comodulation of Nonengaged TCR Takes Place by a Protein Kinase C and CD3{gamma} Di-Leucine-Based Motif-Dependent Mechanism
J. Immunol., September 15, 2003; 171(6): 3003 - 3009.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. S. Torres, A. Alcover, D. A. Zapata, J. Arnaud, A. Pacheco, J. M. Martin-Fernandez, E. M. Villasevil, O. Sanal, and J. R. Regueiro
TCR Dynamics in Human Mature T Lymphocytes Lacking CD3{gamma}
J. Immunol., June 15, 2003; 170(12): 5947 - 5955.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. R. Carrasco, M. N. Navarro, and M. L. Toribio
A Role for the Cytoplasmic Tail of the Pre-T Cell Receptor (TCR) alpha Chain in Promoting Constitutive Internalization and Degradation of the Pre-TCR
J. Biol. Chem., April 11, 2003; 278(16): 14507 - 14513.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. M. Badran, S. M. Wolinsky, A. Burny, and K. E. Willard-Gallo
Identification of Three NFAT Binding Motifs in the 5'-Upstream Region of the Human CD3gamma Gene That Differentially Bind NFATc1, NFATc2, and NF-kappa B p50
J. Biol. Chem., November 27, 2002; 277(49): 47136 - 47148.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
P. S. Torres, D. A. Zapata, A. Pacheco-Castro, J. L. Rodriguez-Fernandez, C. Cabanas, and J. R. Regueiro
Contribution of CD3{gamma} to TCR regulation and signaling in human mature T lymphocytes
Int. Immunol., November 1, 2002; 14(11): 1357 - 1367.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.