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The Journal of Immunology, 2002, 168: 4414-4419.
Copyright © 2002 by The American Association of Immunologists

Aberrant Expression of Fas Ligand in Mice Deficient for the MHC Class II Transactivator1

Tania S. Gourley*, Dipak R. Patel*, Kevin Nickerson*, Soon-Cheol Hong{dagger} and Cheong-Hee Chang2,*,{dagger}

* Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109; and {dagger} Department of Microbiology and Immunology, Walther Oncology Center, Indiana University, Indianapolis, IN 46202

The MHC class II transactivator (CIITA) is a critical regulator of MHC class II genes and other genes involved in the Ag presentation pathway. CIITA-deficient mice lack MHC class II expression on almost all APCs. In this study, we show that these mice also have aberrant Fas ligand expression on both CD4 T cells and B cells. We found that Fas ligand expression was greatly increased on CIITA-deficient CD4 T cells during the Th1 differentiation process. However, both CIITA-deficient and control Th1 effector cells up-regulated Fas ligand to similar levels if cells were reactivated. The introduction of CIITA into primary CD4 T cells via retroviral infection resulted in a reduction in the level of Fas ligand and delay in apoptosis after activation. Interestingly, activated B cells from the CIITA-deficient mice also showed increased levels of Fas ligand that could be to some degree inhibited by the introduction of IL-4.




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