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The Journal of Immunology, 2002, 168: 4272-4276.
Copyright © 2002 by The American Association of Immunologists


Cutting Edge

Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation1

Edward Y. Woo2,{dagger}, Heidi Yeh2,{dagger}, Christina S. Chu{ddagger}, Katia Schlienger*, Richard G. Carroll*, James L. Riley*, Larry R. Kaiser{dagger} and Carl H. June3,*

* Abramson Family Cancer Research Institute and Departments of {dagger} Surgery and {ddagger} Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104

Active suppression by T regulatory cells plays an important role in the down-regulation of T cell responses to foreign and self-Ags. Thus far, the potential role of CD4+CD25+ T cells in human tumors has not been reported. In this work we show that lung tumors contain large numbers of these cells and that they have constitutive high-level expression of CD152 (CTLA-4). Furthermore, the CD4+CD25+ T cells mediate potent inhibition of autologous T cell proliferation. Finally, regulatory T cells from patient tumors failed to inhibit the proliferation of allogeneic T cells. Together these results suggest that the CD4+CD25+ T cells found in lung tumors selectively inhibit the host immune response and therefore could contribute to the progression of lung cancer.




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