| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
* Medicine/Rheumatology and Immunology,
Biochemistry and Molecular Biology, and
Biostatistics, Mayo Clinic, Rochester, MN 55905
Killer Ig-like receptors (KIRs) are expressed on
CD4+CD28null T cells, a highly oligoclonal
subset of T cells that is expanded in patients with rheumatoid
arthritis. It is unclear at what stage of development these T cells
acquire KIR expression. To determine whether KIR expression is a
consequence of clonal expansion and replicative senescence, multiple
CD4+CD28null T cell clones expressing the in
vivo dominant TCR 
-chain sequences were identified in three patients
and analyzed for their KIR gene expression pattern. Based on sharing of
TCR sequences, the clones were grouped into five clone families. The
repertoire of KIRs was diverse, even within each clone family; however,
the gene expression was not random. Three particular receptors,
KIR2DS2, KIR2DL2, and KIR3DL2, had significant differences in gene
expression frequencies between the clone families. These data suggest
that KIRs are successively acquired after TCR rearrangement, with each
clone family developing a dominant expression pattern. The patterns did
not segregate with the individual from whom the clones were derived,
indicating that peripheral selection in the host environment was not a
major shaping force. Several models were examined using a computer
algorithm that was designed to simulate the expression of KIRs at
various times during T cell proliferation. The computer simulations
favored a model in which KIR gene expression is inducible for a limited
time during the initial stages of clonal
expansion.
This article has been cited by other articles:
|
|
 |
|
  G. Li, M. Yu, C. M. Weyand, and J. J. Goronzy Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells Blood, October 15, 2009; 114(16): 3422 - 3430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. van Bergen, E. M. C. Kooy-Winkelaar, H. van Dongen, F. A. van Gaalen, A. Thompson, T. W. J. Huizinga, M. C. W. Feltkamp, R. E. M. Toes, and F. Koning Functional Killer Ig-Like Receptors on Human Memory CD4+ T Cells Specific for Cytomegalovirus J. Immunol., April 1, 2009; 182(7): 4175 - 4182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. T. van der Veken, M. Diez Campelo, M. A. W. G. van der Hoorn, R. S. Hagedoorn, H. M. E. van Egmond, J. van Bergen, R. Willemze, J. H. F. Falkenburg, and M. H. M. Heemskerk Functional Analysis of Killer Ig-Like Receptor-Expressing Cytomegalovirus-Specific CD8+ T Cells J. Immunol., January 1, 2009; 182(1): 92 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. E. Dumitriu, E. T. Araguas, C. Baboonian, and J. C. Kaski CD4+CD28null T cells in coronary artery disease: when helpers become killers Cardiovasc Res, January 1, 2009; 81(1): 11 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zal, J. C. Kaski, J. P. Akiyu, D. Cole, G. Arno, J. Poloniecki, A. Madrigal, A. Dodi, and C. Baboonian Differential Pathways Govern CD4+CD28- T Cell Proinflammatory and Effector Responses in Patients with Coronary Artery Disease J. Immunol., October 15, 2008; 181(8): 5233 - 5241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Studer, M. P. George, X. Zhu, Y. Song, V. G. Valentine, M. W. Stoner, J. Sethi, C. Steele, and S. R. Duncan CD28 Down-Regulation on CD4 T Cells Is a Marker for Graft Dysfunction in Lung Transplant Recipients Am. J. Respir. Crit. Care Med., October 1, 2008; 178(7): 765 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, C. M. Weyand, and J. J. Goronzy Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells J. Leukoc. Biol., September 1, 2008; 84(3): 824 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Thewissen, V. Somers, N. Hellings, J. Fraussen, J. Damoiseaux, and P. Stinissen CD4+CD28null T Cells in Autoimmune Disease: Pathogenic Features and Decreased Susceptibility to Immunoregulation J. Immunol., November 15, 2007; 179(10): 6514 - 6523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Henel, K. Singh, D. Cui, S. Pryshchep, W.-W. Lee, C. M. Weyand, and J. J. Goronzy Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors Blood, June 1, 2006; 107(11): 4449 - 4457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ortonne, D. Huet, C. Gaudez, A. Marie-Cardine, V. Schiavon, M. Bagot, P. Musette, and A. Bensussan Significance of circulating T-cell clones in Sezary syndrome Blood, May 15, 2006; 107(10): 4030 - 4038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. L. Teng, M. H. Kershaw, Y. Hayakawa, L. Cerutti, S. M. Jane, P. K. Darcy, and M. J. Smyth T Cells Gene-engineered with DAP12 Mediate Effector Function in an NKG2D-dependent and Major Histocompatibility Complex-independent Manner J. Biol. Chem., November 18, 2005; 280(46): 38235 - 38241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Amyes, A. J. McMichael, and M. F. C. Callan Human CD4+ T Cells Are Predominantly Distributed among Six Phenotypically and Functionally Distinct Subsets J. Immunol., November 1, 2005; 175(9): 5765 - 5773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, A. N. Vallejo, Y. Jiang, C. M. Weyand, and J. J. Goronzy Distinct Transcriptional Control Mechanisms of Killer Immunoglobulin-like Receptors in Natural Killer (NK) and in T Cells J. Biol. Chem., June 24, 2005; 280(25): 24277 - 24285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Gniadecki and A. Lukowsky Monoclonal T-Cell Dyscrasia of Undetermined Significance Associated With Recalcitrant Erythroderma Arch Dermatol, March 1, 2005; 141(3): 361 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Taneja, N. Taneja, M. Behrens, M. M. Griffiths, H. S. Luthra, and C. S. David Requirement for CD28 May Not Be Absolute for Collagen-Induced Arthritis: Study with HLA-DQ8 Transgenic Mice J. Immunol., January 15, 2005; 174(2): 1118 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Anfossi, J.-M. Doisne, M.-A. Peyrat, S. Ugolini, O. Bonnaud, D. Bossy, V. Pitard, P. Merville, J.-F. Moreau, J.-F. Delfraissy, et al. Coordinated Expression of Ig-Like Inhibitory MHC Class I Receptors and Acquisition of Cytotoxic Function in Human CD8+ T Cells J. Immunol., December 15, 2004; 173(12): 7223 - 7229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Snyder, T. Nakajima, P. J. Leibson, C. M. Weyand, and J. J. Goronzy Stimulatory Killer Ig-Like Receptors Modulate T Cell Activation through DAP12-Dependent and DAP12-Independent Mechanisms J. Immunol., September 15, 2004; 173(6): 3725 - 3731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Wagner, M. Pierer, M. Wahle, F. Moritz, S. Kaltenhauser, and H. Hantzschel Ex Vivo Homeostatic Proliferation of CD4+ T Cells in Rheumatoid Arthritis Is Dysregulated and Driven by Membrane-Anchored TNF{alpha} J. Immunol., August 15, 2004; 173(4): 2825 - 2833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Lewis, M. Merched-Sauvage, J. J. Goronzy, C. M. Weyand, and A. N. Vallejo Tumor Necrosis Factor-{alpha} and CD80 Modulate CD28 Expression through a Similar Mechanism of T-cell Receptor-independent Inhibition of Transcription J. Biol. Chem., July 9, 2004; 279(28): 29130 - 29138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bornhauser, R. Schwerdtfeger, H. Martin, K.-H. Frank, C. Theuser, G. Ehninger, F. Locatelli, A. Velardi, and S. Giebel Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors Blood, April 1, 2004; 103(7): 2860 - 2861. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Groh, A. Bruhl, H. El-Gabalawy, J. L. Nelson, and T. Spies Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis PNAS, August 5, 2003; 100(16): 9452 - 9457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Stewart, J. van Bergen, and J. Trowsdale Different and Divergent Regulation of the KIR2DL4 and KIR3DL1 Promoters J. Immunol., June 15, 2003; 170(12): 6073 - 6081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Warrington, A. N. Vallejo, C. M. Weyand, and J. J. Goronzy CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation Blood, May 1, 2003; 101(9): 3543 - 3549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Snyder, M. Lucas, E. Vivier, C. M. Weyand, and J. J. Goronzy Selective Activation of the c-Jun NH2-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4+ T Cells J. Exp. Med., February 17, 2003; 197(4): 437 - 449. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
