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Departments of
* Microbiology and Immunology and
Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women’s Medical University, and
Medical Devices and Diagnostics Research Laboratories, Toray Industries, Ohtsu, Japan
We analyzed the responses of several T cell fractions reactive with
superantigenic toxins (SAGTs), staphylococcal enterotoxin A (SEA), or
Yersinia pseudotuberculosis-derived mitogen (YPM) in
mice implanted with mini-osmotic pumps filled with SEA or YPM. In mice
implanted with the SEA pump, SEA-reactive
V
3+CD4+ T cells exhibited a
high-level protracted expansion for 30 days, and SEA-reactive
V11+CD4+ T cells
exhibited a low-level protracted expansion. SEA-reactive
CD8+ counterparts exhibited only a transient
expansion. A similar difference in T cell expansion was also observed
in YPM-reactive T cell fractions in mice implanted with the YPM pump.
V3+CD4+ and
V11+CD4+ T cells
from mice implanted with the SEA pump exhibited cell divisions upon in
vitro restimulation with SEA and expressed surface phenotypes as memory
T cells. CD4+ T cells from mice implanted with
the SEA pump exhibited high IL-4 production upon in vitro restimulation
with SEA, which was due to the enhanced capacity of the SEA-reactive
CD4+ T cells to produce IL-4. The findings in
the present study indicate that, in mice implanted with a specific
SAGT, the level of expansion of the SAGT-reactive
CD4+ T cell fractions varies widely depending
on the TCR V elements expressed and that the reactive
CD4+ T cells acquire a capacity to raise a memory response.
CD8+ T cells are low responders to
SAGTs.
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