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The Journal of Immunology, 2002, 168: 3702-3706.
Copyright © 2002 by The American Association of Immunologists

Cutting Edge

Cutting Edge: DNA Polymerases µ and {lambda} Are Dispensable for Ig Gene Hypermutation1

Barbara Bertocci*, Annie De Smet*, Eric Flatter*, Auriel Dahan*, Jean-Christophe Bories{dagger}, Catherine Landreau{ddagger}, Jean-Claude Weill2,* and Claude-Agnès Reynaud2,3,*

* Institut National de la Santé et de la Recherche Médicale, Unité 373, Faculté de Médecine Necker-Enfants Malades, and {dagger} Institut National de la Santé et de la Recherche Médicale, Unité 462, Hôpital Saint-Louis, Center Hayem, Paris, France; and {ddagger} Service d’Expérimentation Animale et de Transgénèse du Centre National de la Recherche Scientifique, Villejuif, France

Mutations arising in Ig V genes during an immune response are most likely introduced by one or several error-prone DNA polymerases. Many of the recently described nonreplicative DNA polymerases have an intrinsic fidelity compatible with such an activity, the strongest candidates being polymerase (pol) {eta}, pol {iota}, pol {zeta}, and pol µ. We report in this work that mice inactivated for either of the two polymerases related to pol {beta} (i.e., pol µ and pol {lambda}) are viable and fertile and display a normal hypermutation pattern.




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