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Cutting Edge |
Receptors1
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742
An immune response can deviate toward either a Th1- or Th2-like
response. In this work we examine the contribution that activated
macrophages and IgG Abs make toward this deviation. The use of
activated macrophages as APCs resulted in a strong polarized T cell
response that was predominated by IFN-
. However, when Ag was
targeted to FcRs on these macrophages, the T cell response was
reversed and biased toward a Th2-like response. This Th2-like phenotype
was stable and was retained when the T cells were subsequently
restimulated under nonbiasing conditions. The T cell biasing and its
reversal via FcR was also observed in vivo. Mice vaccinated with
IgG-opsonized OVA made high levels of IgG Ab of the IgG1 isotype. These
studies demonstrate that the ligation of FcR on activated
macrophages can reverse the Th1 biasing that occurs as a result of
innate immune responses to microbial products.
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F. P. Polack, M. N. Teng, P. L.Collins, G. A. Prince, M. Exner, H. Regele, D. D. Lirman, R. Rabold, S. J. Hoffman, C. L. Karp, et al. A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease J. Exp. Med., September 16, 2002; 196(6): 859 - 865. [Abstract] [Full Text] [PDF]
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G. J. Randolph, G. Sanchez-Schmitz, R. M. Liebman, and K. Schakel The CD16+ (Fc{gamma}RIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting J. Exp. Med., August 19, 2002; 196(4): 517 - 527. [Abstract] [Full Text] [PDF]
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