| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,
*
Istituto di Patologia Generale, Università degli Studi di Milano, Milan, Italy;
Pharma Division, Preclinical Centre National Scientifique Research, F. Hoffmann-La Roche, Basel, Switzerland;
Department of Biotechnology and Biomedical Sciences, Section of General Pathology and Immunology, University of Brescia, Brescia, Italy;
Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
The gene expression profile induced by the CC chemokine ligand
(CCL) 5/RANTES in human monocytes was examined using the
oligonucleotide array technology. Of 5600 transcripts examined, 42 were
consistently induced by CCL5, and none were suppressed.
Chemokine-inducible transcripts could be clustered in functional
groups, including selected cytokines and receptors (e.g., IL-1
,
CCL2/monocyte chemotactic protein-1, and the CCL5 receptor CCR1) and
molecules involved in extracellular matrix recognition and digestion
(e.g., CD44 splice transcripts, urokinase-type plasminogen activator
receptor, matrix metalloprotease (MMP)-9 , and MMP-19). Transcript
expression, confirmed by quantitative real-time PCR analysis for
selected genes, was associated with protein induction for some (e.g.,
CCL2), but not all (e.g., IL-1), transcripts examined. The
chemokine-induced gene profile was distinct from that activated by LPS,
a prototypic phagocyte activator. Although certain transcripts were
stimulated by both agonists (e.g., IL-1 and CCL2), others were
induced only by either LPS (e.g., TNF-
and IL-6) or CCL5 (e.g.,
MMP-19) or were divergently regulated (e.g., CCR1). Thus, CCL5, a
prototypic CC inflammatory chemokine, activates a restricted
transcriptional program in monocytes distinct from that induced by the
prototypic pathogen-derived proinflammatory stimulant LPS.
Chemokine-induced chemokines production could represent a novel
amplification loop of leukocyte recruitment, while a subset of
chemokine-inducible transcripts could be involved in monocyte
extravasation and tissue invasion.
This article has been cited by other articles:
|
|
 |
|
  R. Mihrshahi, A. N. Barclay, and M. H. Brown Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells J. Immunol., October 15, 2009; 183(8): 4879 - 4886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. TAHARA, T. SHIBATA, M. NAKAMURA, H. YAMASHITA, D. YOSHIOKA, I. HIRATA, and T. ARISAWA RANTES Promoter Genotype and Gastric Cancer Risk in a Japanese Population Anticancer Res, October 1, 2009; 29(10): 4265 - 4269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chan, E. R. Bivins-Smith, M. S. Smith, P. M. Smith, and A. D. Yurochko Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage J. Immunol., July 1, 2008; 181(1): 698 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Guruvayoorappan Tumor Versus Tumor-Associated Macrophages: How Hot is the Link? Integr Cancer Ther, June 1, 2008; 7(2): 90 - 95. [Abstract] [PDF]
|
|
|
|
 |
|
 B. E. Bachmeier, I. V. Mohrenz, V. Mirisola, E. Schleicher, F. Romeo, C. Hohneke, M. Jochum, A. G. Nerlich, and U. Pfeffer Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NF{kappa}B Carcinogenesis, April 1, 2008; 29(4): 779 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wels, R. N. Kaplan, S. Rafii, and D. Lyden Migratory neighbors and distant invaders: tumor-associated niche cells Genes & Dev., March 1, 2008; 22(5): 559 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sutton, V. Friand, D. Papy-Garcia, M. Dagouassat, L. Martin, R. Vassy, O. Haddad, O. Sainte-Catherine, M. Kraemer, L. Saffar, et al. Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells Mol. Cancer Ther., November 1, 2007; 6(11): 2948 - 2958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. M. Dirkx, M. G. A. oude Egbrink, J. Wagstaff, and A. W. Griffioen Monocyte/macrophage infiltration in tumors: modulators of angiogenesis J. Leukoc. Biol., December 1, 2006; 80(6): 1183 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shahrara, C. C. Park, V. Temkin, J. W. Jarvis, M. V. Volin, and R. M. Pope RANTES Modulates TLR4-Induced Cytokine Secretion in Human Peripheral Blood Monocytes J. Immunol., October 15, 2006; 177(8): 5077 - 5087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lamagna, M. Aurrand-Lions, and B. A. Imhof Dual role of macrophages in tumor growth and angiogenesis J. Leukoc. Biol., October 1, 2006; 80(4): 705 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sironi, F. O. Martinez, D. D'Ambrosio, M. Gattorno, N. Polentarutti, M. Locati, A. Gregorio, A. Iellem, M. A. Cassatella, J. Van Damme, et al. Differential regulation of chemokine production by Fc{gamma} receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2) J. Leukoc. Biol., August 1, 2006; 80(2): 342 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chabot, P. Reverdiau, S. Iochmann, A. Rico, D. Senecal, C. Goupille, P.-Y. Sizaret, and L. Sensebe CCL5-enhanced human immature dendritic cell migration through the basement membrane in vitro depends on matrix metalloproteinase-9 J. Leukoc. Biol., April 1, 2006; 79(4): 767 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Skwor, H. Cho, C. Cassidy, T. Yoshimura, and D. N. McMurray Recombinant guinea pig CCL5 (RANTES) differentially modulates cytokine production in alveolar and peritoneal macrophages J. Leukoc. Biol., December 1, 2004; 76(6): 1229 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Ness, K. J. Carpenter, J. L. Ewing, C. J. Gerard, C. M. Hogaboam, and S. L. Kunkel CCR1 and CC Chemokine Ligand 5 Interactions Exacerbate Innate Immune Responses during Sepsis J. Immunol., December 1, 2004; 173(11): 6938 - 6948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Murdoch, A. Giannoudis, and C. E. Lewis Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues Blood, October 15, 2004; 104(8): 2224 - 2234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bertini, M. Allegretti, C. Bizzarri, A. Moriconi, M. Locati, G. Zampella, M. N. Cervellera, V. Di Cioccio, M. C. Cesta, E. Galliera, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury PNAS, August 10, 2004; 101(32): 11791 - 11796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Perrier, F. O. Martinez, M. Locati, G. Bianchi, M. Nebuloni, G. Vago, F. Bazzoni, S. Sozzani, P. Allavena, and A. Mantovani Distinct Transcriptional Programs Activated by Interleukin-10 with or without Lipopolysaccharide in Dendritic Cells: Induction of the B Cell-Activating Chemokine, CXC Chemokine Ligand 13 J. Immunol., June 1, 2004; 172(11): 7031 - 7042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gross, C. A. Amella, L. Pompucci, G. Franchin, B. Sherry, and H. Schmidtmayerova Macrophages and lymphocytes differentially modulate the ability of RANTES to inhibit HIV-1 infection J. Leukoc. Biol., November 1, 2003; 74(5): 781 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alfano, N. Sidenius, F. Blasi, and G. Poli The role of urokinase-type plasminogen activator (uPA)/uPA receptor in HIV-1 infection J. Leukoc. Biol., November 1, 2003; 74(5): 750 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakajima, Y. Tanaka, T. Nomiyama, T. Ogihara, F. Ikeda, R. Kanno, N. Iwashita, K. Sakai, H. Watada, T. Onuma, et al. RANTES Promoter Genotype Is Associated With Diabetic Nephropathy in Type 2 Diabetic Subjects Diabetes Care, March 1, 2003; 26(3): 892 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alfano, N. Sidenius, B. Panzeri, F. Blasi, and G. Poli Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication PNAS, June 25, 2002; 99(13): 8862 - 8867. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
