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3 Lymphocytes1
Department of Clinical Chemistry, Microbiology, and Immunology, University of Ghent, University Hospital, Ghent, Belgium
Ly49 and CD94/NKG2 inhibitory receptors are predominantly expressed
on murine NK cells, but they are also expressed on a subpopulation of
peripheral CD8 memory TCR 
lymphocytes. In this study we
demonstrate that Ly49E and CD94/NKG2 receptors are expressed on mature
TCR V
3+ cells in the fetal thymus. Expression correlated
with a memory phenotype, such as expression of CD44, 2B4, and IL-2R
(CD122), and absence of IL-2R (CD25) expression. No expression of
Ly49A, C, D, G2, or I receptors was observed. This phenotype is similar
to that of fetal thymic NK cells. Skin-located V3 T cells, the
progeny of fetal thymic V3 cells, also expressed CD94/NKG2 and Ly49E
but not the other members of the Ly49 family. The development and
survival of Ly49E+ or CD94/NKG2+ V3 T
lymphocytes was not dependent upon expression of MHC class I molecules.
The cytotoxicity of TCR V3 cells was inhibited when Qdm, the ligand
for CD94/NKG2, was presented by Qa1b-transfected target
cells. Also, upon cross-linking of CD94/NKG2 with mAb 3S9, TCR V3
thymocytes were prevented from killing FcR+ P815 target
cells. These effects were most pronounced in the
CD94/NKG2high subpopulation as compared with the
CD94/NKG2low subpopulation of V3 cells. Our data
demonstrate that V3 T cells expressing inhibitory Ly49E and
CD94/NKG2 receptors are mature and display a memory phenotype, and that
CD94/NKG2 functions as an inhibitory receptor on these T
lymphocytes.
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