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,
*
Virginia Mason Research Center, Seattle, WA 98101;
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263; and Departments of
Immunology and
Biological Structure, University of Washington, Seattle, WA 98195
Thymic stromal lymphopoietin (TSLP) is a cytokine that facilitates
B lymphocyte differentiation and costimulates T cells. Previous studies
have demonstrated that a functional TSLP receptor complex is a
heterodimer consisting of the TSLP receptor and the IL-7R 
-chain.
TSLP-mediated signaling is unique among members of the cytokine
receptor family in that activation of the transcription factor Stat5
occurs without detectable Janus kinase activation. Using a variety of
biological systems we demonstrate here that TSLP-mediated Stat5
activation can be uncoupled from proliferation. We also show that the
single tyrosine residue in the cytoplasmic domain of the TSLP receptor
is critical for TSLP-mediated proliferation, but is dispensable for
Stat5 activation. Our data demonstrate that TSLP-mediated Stat5
activation is insufficient for cell proliferation and identifies
residues within the TSLP receptor complex required to mediate these
downstream events.
This article has been cited by other articles:
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 C. A. J. Vosshenrich, A. Cumano, W. Muller, J. P. Di Santo, and P. Vieira Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment PNAS, July 27, 2004; 101(30): 11070 - 11075. [Abstract] [Full Text] [PDF]
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A. Al-Shami, R. Spolski, J. Kelly, T. Fry, P. L. Schwartzberg, A. Pandey, C. L. Mackall, and W. J. Leonard A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development J. Exp. Med., July 19, 2004; 200(2): 159 - 168. [Abstract] [Full Text] [PDF]
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 M. J. Osborn, P. L. Ryan, N. Kirchhof, A. Panoskaltsis-Mortari, F. Mortari, and K.-S. R. S. Tudor Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis Blood, February 1, 2004; 103(3): 843 - 851. [Abstract] [Full Text] [PDF]
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