| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Locus Secondary Rearrangement: Role in Tolerance Induction1
,
*
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;
Laboratoire d’Immunobiologie, Université Denis Diderot, Paris, France; and
Departments of Immunology and Medial Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
Immunization with superantigen in vivo induces transient activation
of superantigen-specific T cells, followed by a
superantigen-nonresponsive state. In this study, using a TCR 
knock-in mouse in which the knock-in -chain can be replaced with
endogenous -chain through secondary rearrangement, we show that
immunization of superantigen changes the TCR -chain expression on
peripheral superantigen-specific T cells, induces expression of
recombination-activating genes, and generates DNA double-strand breaks
at the TCR -chain locus. These results suggest that viral
superantigens are capable of inducing peripheral TCR revision. Our
findings thus provide a new perspective on pathogen-immune system
interaction.
This article has been cited by other articles:
|
|
 |
|
  D. Zehn, M. J. Bevan, and P. J. Fink Cutting Edge: TCR Revision Affects Predominantly Foxp3 Cells and Skews Them toward the Th17 Lineage J. Immunol., November 1, 2007; 179(9): 5653 - 5657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takase, E. M. Kanagawa, and O. Kanagawa Age-Dependent TCR Revision Mediated by Interaction between {alpha}beta TCR and Self-Antigens J. Immunol., August 15, 2007; 179(4): 2163 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Cooper, G. L. Turk, M. Sun, A. G. Farr, and P. J. Fink Cutting Edge: TCR Revision Occurs in Germinal Centers J. Immunol., December 1, 2004; 173(11): 6532 - 6536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ali, M. Weinreich, S. Balcaitis, C. J. Cooper, and P. J. Fink Differential Regulation of Peripheral CD4+ T Cell Tolerance Induced by Deletion and TCR Revision J. Immunol., December 1, 2003; 171(11): 6290 - 6296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Cooper, M. T. Orr, C. J. McMahan, and P. J. Fink T Cell Receptor Revision Does Not Solely Target Recent Thymic Emigrants J. Immunol., July 1, 2003; 171(1): 226 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Serra, A. Amrani, B. Han, J. Yamanouchi, S. J. Thiessen, and P. Santamaria RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytes PNAS, November 26, 2002; 99(24): 15566 - 15571. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
