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The Journal of Immunology, 2002, 168: 3195-3204.
Copyright © 2002 by The American Association of Immunologists

IFN-{gamma}-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking1

Jennifer H. Dufour2,*, Michelle Dziejman3,*, Michael T. Liu{dagger}, Josephine H. Leung*, Thomas E. Lane{dagger} and Andrew D. Luster4,*

* Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; and {dagger} Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697

IFN-{gamma}-inducible protein 10 (IP-10, CXCL10), a chemokine secreted from cells stimulated with type I and II IFNs and LPS, is a chemoattractant for activated T cells. Expression of IP-10 is seen in many Th1-type inflammatory diseases, where it is thought to play an important role in recruiting activated T cells into sites of tissue inflammation. To determine the in vivo function of IP-10, we constructed an IP-10-deficient mouse (IP-10-/-) by targeted gene disruption. Immunological analysis revealed that IP-10-/- mice had impaired T cell responses. T cell proliferation to allogeneic and antigenic stimulation and IFN-{gamma} secretion in response to antigenic challenge were impaired in IP-10-/- mice. In addition, IP-10-/- mice exhibited an impaired contact hypersensitivity response, characterized by decreased ear swelling and reduced inflammatory cell infiltrates. T cells recovered from draining lymph nodes also had a decreased proliferative response to Ag restimulation. Furthermore, IP-10-/- mice infected with a neurotropic mouse hepatitis virus had an impaired ability to control viral replication in the brain. This was associated with decreased recruitment of CD4+ and CD8+ lymphocytes into the brain, reduced levels of IFN-{gamma} and the IFN-{gamma}-induced chemokines monokine induced by IFN-{gamma} (Mig, CXCL9) and IFN-inducible T cell {alpha} chemoattractant (I-TAC, CXCL11) in the brain, decreased numbers of virus-specific IFN-{gamma}-secreting CD8+ cells in the spleen, and reduced levels of demyelination in the CNS. Taken together, our data suggest a role for IP-10 in both effector T cell generation and trafficking in vivo.




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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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Microbiol. Mol. Biol. Rev., December 1, 2005; 69(4): 635 - 664.
[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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J. Leukoc. Biol., September 1, 2005; 78(3): 716 - 724.
[Abstract] [Full Text] [PDF]


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Am. J. Pathol., September 1, 2005; 167(3): 887 - 899.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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J. Virol.Home page
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Role of CXCR3 in the Immune Response to Murine Gammaherpesvirus 68
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[Abstract] [Full Text] [PDF]


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J. Neurosci.Home page
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J. Neurosci., July 13, 2005; 25(28): 6576 - 6583.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
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[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
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J. Immunol., July 1, 2005; 175(1): 450 - 460.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
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J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1263 - 1271.
[Abstract] [Full Text] [PDF]


Home page
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