| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cutting Edge |
24+CD8+ NK T Cells Activated by -Galactosylceramide-Pulsed Monocyte-Derived Dendritic Cells
Departments of
*
Hematology and Oncology,
Transfusion Medicine,
Urology, and
Surgery, Graduate School of Medicine, University of Tokyo, and
¶ Department of Research, The Japanese Red Central Blood Center, Tokyo, Japan
Human V
24+ NKT cells constitute a counterpart of
mouse V14+ NKT cells, both of which use an invariant
TCR- chain. The human V24+ NKT cells as well as mouse
V14+ NKT cells are activated by glycolipids in a
CD1d-restricted manner and produce many immunomodulatory cytokines,
possibly affecting the immune balance. In mice, it has been considered
from extensive investigations that
V14+CD8+ NKT cells that express invariant
TCR do not exist. Here we introduce human
V24+CD8+ NKT cells. These cells share
important features of V24+ NKT cells in common, but in
contrast to CD4-CD8- (double-negative) or
CD4+ V24+ NKT cells, they do not produce
IL-4. Our discovery may extend and deepen the research field of
V24+ NKT cells as well as help to understand the
mechanism of the immune balance-related
diseases.
This article has been cited by other articles:
|
|
 |
|
  G. Bricard, V. Cesson, E. Devevre, H. Bouzourene, C. Barbey, N. Rufer, J. S. Im, P. M. Alves, O. Martinet, N. Halkic, et al. Enrichment of Human CD4+ V{alpha}24/V{beta}11 Invariant NKT Cells in Intrahepatic Malignant Tumors J. Immunol., April 15, 2009; 182(8): 5140 - 5151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kis, P. Engelmann, K. Farkas, G. Richman, S. Eck, J. Lolley, H. Jalahej, M. Borowiec, S. C. Kent, A. Treszl, et al. Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus J. Leukoc. Biol., March 1, 2007; 81(3): 654 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mitsuo, S. Morimoto, Y. Nakiri, J. Suzuki, H. Kaneko, Y. Tokano, H. Tsuda, Y. Takasaki, and H. Hashimoto Decreased CD161+CD8+ T cells in the peripheral blood of patients suffering from rheumatic diseases Rheumatology, December 1, 2006; 45(12): 1477 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Motohashi, A. Ishikawa, E. Ishikawa, M. Otsuji, T. Iizasa, H. Hanaoka, N. Shimizu, S. Horiguchi, Y. Okamoto, S.-i. Fujii, et al. A Phase I Study of In vitro Expanded Natural Killer T Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer Clin. Cancer Res., October 15, 2006; 12(20): 6079 - 6086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lin, M. Nieda, J. F. Hutton, V. Rozenkov, and A. J. Nicol Comparative gene expression analysis of NKT cell subpopulations J. Leukoc. Biol., July 1, 2006; 80(1): 164 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sen, B. Yongyi, H. Yuling, X. Luokun, H. Li, X. Jie, D. Tao, Z. Gang, L. Junyan, H. Chunsong, et al. V{alpha}24-Invariant NKT Cells from Patients with Allergic Asthma Express CCR9 at High Frequency and Induce Th2 Bias of CD3+ T Cells upon CD226 Engagement J. Immunol., October 15, 2005; 175(8): 4914 - 4926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-P. Ho, B. C. Urban, L. Jones, G. S. Ogg, and A. J. McMichael CD4-CD8{alpha}{alpha} Subset of CD1d-Restricted NKT Cells Controls T Cell Expansion J. Immunol., June 15, 2004; 172(12): 7350 - 7358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Esteban, T. Tsoutsman, M. A. Jordan, D. Roach, L. D. Poulton, A. Brooks, O. V. Naidenko, S. Sidobre, D. I. Godfrey, and A. G. Baxter Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci J. Immunol., September 15, 2003; 171(6): 2873 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kenna, L. G. Mason, S. A. Porcelli, Y. Koezuka, J. E. Hegarty, C. O'Farrelly, and D. G. Doherty NKT Cells from Normal and Tumor-Bearing Human Livers Are Phenotypically and Functionally Distinct from Murine NKT Cells J. Immunol., August 15, 2003; 171(4): 1775 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Azuma, T. Takahashi, A. Kunisato, T. Kitamura, and H. Hirai Human CD4+ CD25+ Regulatory T Cells Suppress NKT Cell Functions Cancer Res., August 1, 2003; 63(15): 4516 - 4520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Motsinger, A. Azimzadeh, A. K. Stanic, R. P. Johnson, L. Van Kaer, S. Joyce, and D. Unutmaz Identification and Simian Immunodeficiency Virus Infection of CD1d-Restricted Macaque Natural Killer T Cells J. Virol., July 15, 2003; 77(14): 8153 - 8158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Gansert, V. Kiebler, M. Engele, F. Wittke, M. Rollinghoff, A. M. Krensky, S. A. Porcelli, R. L. Modlin, and S. Stenger Human NKT Cells Express Granulysin and Exhibit Antimycobacterial Activity J. Immunol., March 15, 2003; 170(6): 3154 - 3161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lucas, S. Gadola, U. Meier, N. T. Young, G. Harcourt, A. Karadimitris, N. Coumi, D. Brown, G. Dusheiko, V. Cerundolo, et al. Frequency and Phenotype of Circulating V{alpha}24/V{beta}11 Double-Positive Natural Killer T Cells during Hepatitis C Virus Infection J. Virol., February 1, 2003; 77(3): 2251 - 2257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Gurney, O. O. Yang, S. B. Wilson, and C. H. Uittenbogaart TCR{gamma}{delta}+ and CD161+ Thymocytes Express HIV-1 in the SCID-hu Mouse, Potentially Contributing to Immune Dysfunction in HIV Infection J. Immunol., November 1, 2002; 169(9): 5338 - 5346. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
