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Cutting Edge |
,
*
Department of Immunology, Instituto Nacional de Cardiologia "Ignacio Chavez," Mexico, D.F. Mexico;
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115; and
Department of Microbiology, Ohio State University, Columbus, OH 43210
Using STAT6-/- BALB/c mice, we analyzed the role
of STAT6-induced Th2 response in determining the outcome of murine
cysticercosis caused by the helminth parasite Taenia
crassiceps. After T. crassiceps
infection, wild-type BALB/c mice developed a strong
Th2-like response; produced high levels of IgG1, IgE, IL-4, as well as
IL-13; and remained susceptible to T. crassiceps. In
contrast, similarly infected STAT6-/- mice
mounted a strong Th1-like response; produced high levels of IgG2a,
IL-12, IFN-
, as well as nitric oxide; and efficiently controlled
T. crassiceps infection. These findings demonstrate that
Th2-like response induced via STAT6-mediated signaling pathway mediates
susceptibility to T. crassiceps and, furthermore, that
unlike the case in most helminths, immunity against T.
crassiceps is mediated by a Th1-like rather than Th2-like
response.
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