| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cutting Edge |
*
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143;
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232;
Division of Biology, California Institute of Technology, Pasadena, CA 91125; and
The Jackson Laboratory, Bar Harbor, ME 04609
Minor histocompatibility Ags elicit cell-mediated immune responses and graft rejection in individuals receiving MHC-matched tissues. H60 represents a dominant Ag that elicits a strong CTL response in C57BL/6 mice immunized against BALB.B. An 8-aa peptide in the H60 protein is presented by H-2Kb and this is recognized by the TCR as an alloantigen. The intact H60 glycoprotein is a ligand for the costimulatory NKG2D receptor that is expressed by activated CD8+ T cells. Thus, H60 may provide both an allogeneic peptide and its own costimulation. We show that mutation of an H-2Kb-binding anchor residue in the H60 peptide completely abrogates binding of H60 glycoprotein to NKG2D and a synthetic H60 peptide partially blocks the binding of NKG2D to its ligand. Ligands of the human NKG2D receptor are remarkably polymorphic, suggesting that these may also serve as minor histocompatibility Ags.
This article has been cited by other articles:
|
|
 |
|
  A. Takada, S. Yoshida, M. Kajikawa, Y. Miyatake, U. Tomaru, M. Sakai, H. Chiba, K. Maenaka, D. Kohda, K. Fugo, et al. Two Novel NKG2D Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to NKG2D J. Immunol., February 1, 2008; 180(3): 1678 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hyka-Nouspikel, L. Lucian, E. Murphy, T. McClanahan, and J. H. Phillips DAP10 Deficiency Breaks the Immune Tolerance against Transplantable Syngeneic Melanoma J. Immunol., September 15, 2007; 179(6): 3763 - 3771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, F. M. Ellison, M. A. Eckhaus, A. L. Smith, K. Keyvanfar, R. T. Calado, and N. S. Young Minor Antigen H60-Mediated Aplastic Anemia Is Ameliorated by Immunosuppression and the Infusion of Regulatory T Cells J. Immunol., April 1, 2007; 178(7): 4159 - 4168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Kappel, J. Pinilla-Ibarz, A. A. Kochman, J. M. Eng, V. M. Hubbard, I. Leiner, E. G. Pamer, G. Heller, M. R. M. van den Brink, and D. A. Scheinberg Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model Blood, March 1, 2006; 107(5): 2045 - 2051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhou, Y. Luo, J.-f. Lo, C. D. Kaplan, M. Mizutani, N. Mizutani, J.-D. Lee, F. J. Primus, J. C. Becker, R. Xiang, et al. DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor PNAS, August 2, 2005; 102(31): 10846 - 10851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Sugerman, S. B. Faber, L. M. Willis, A. Petrovic, G. F. Murphy, J. Pappo, D. Silberstein, and M. R. M. van den Brink Kinetics of Gene Expression in Murine Cutaneous Graft-versus-Host Disease Am. J. Pathol., June 1, 2004; 164(6): 2189 - 2202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lodoen, K. Ogasawara, J. A. Hamerman, H. Arase, J. P. Houchins, E. S. Mocarski, and L. L. Lanier NKG2D-mediated Natural Killer Cell Protection Against Cytomegalovirus Is Impaired by Viral gp40 Modulation of Retinoic Acid Early Inducible 1 Gene Molecules J. Exp. Med., May 19, 2003; 197(10): 1245 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Y. Choi, G. J. Christianson, Y. Yoshimura, N. Jung, T. J. Sproule, S. Malarkannan, S. Joyce, and D. C. Roopenian Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease Blood, December 15, 2002; 100(13): 4259 - 4264. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
