The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MacDonald, A. S.
Right arrow Articles by Pearce, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MacDonald, A. S.
Right arrow Articles by Pearce, E. J.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
The Journal of Immunology, 2002, 168: 3127-3130.
Copyright © 2002 by The American Association of Immunologists

Cutting Edge

Cutting Edge: Polarized Th Cell Response Induction by Transferred Antigen-Pulsed Dendritic Cells Is Dependent on IL-4 or IL-12 Production by Recipient Cells1

Andrew S. MacDonald2 and Edward J. Pearce2,3

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853

To assess the influence of dendritic cell (DC) production of polarizing cytokines on Th2 and Th1 development we transferred Ag-pulsed DC generated from wild-type, IL-4-/-, or IL-12-/- mice into wild-type, IL-4-/-, or IL-12-/- recipients. We found that DC IL-4 was not necessary for Th2 induction and that, surprisingly, DC IL-12 was not an absolute requirement for Th1 development. However, DC IL-12 production facilitated optimal Th1 response development. Critically, recipient ability to produce IL-4 or IL-12 was essential for either Th2 or Th1 development. These data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC.




This article has been cited by other articles:


Home page
 JEMHome page
B. Everts, G. Perona-Wright, H. H. Smits, C. H. Hokke, A. J. van der Ham, C. M. Fitzsimmons, M. J. Doenhoff, J. van der Bosch, K. Mohrs, H. Haas, et al.
Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses
J. Exp. Med., August 3, 2009; 206(8): 1673 - 1680.
[Abstract] [Full Text] [PDF]

Home page
 J R Soc InterfaceHome page
J. Thakar, A. Saadatpour-Moghaddam, E. T. Harvill, and R. Albert
Constraint-based network model of pathogen-immune system interactions
J R Soc Interface, July 6, 2009; 6(36): 599 - 612.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Perona-Wright, S. J. Jenkins, R. A. O'Connor, D. Zienkiewicz, H. J. McSorley, R. M. Maizels, S. M. Anderton, and A. S. MacDonald
A Pivotal Role for CD40-Mediated IL-6 Production by Dendritic Cells during IL-17 Induction In Vivo
J. Immunol., March 1, 2009; 182(5): 2808 - 2815.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. Krawczyk, J. Sun, and E. J. Pearce
Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells
J. Immunol., June 15, 2008; 180(12): 7931 - 7937.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Wiethe, A. Debus, M. Mohrs, A. Steinkasserer, M. Lutz, and A. Gessner
Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection
J. Immunol., April 1, 2008; 180(7): 4371 - 4381.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. S. MacDonald and R. M. Maizels
Alarming dendritic cells for Th2 induction
J. Exp. Med., January 21, 2008; 205(1): 13 - 17.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. M. Krawczyk, H. Shen, and E. J. Pearce
Memory CD4 T Cells Enhance Primary CD8 T-Cell Responses
Infect. Immun., July 1, 2007; 75(7): 3556 - 3560.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. J. Ekkens, D. J. Shedlock, E. Jung, A. Troy, E. L. Pearce, H. Shen, and E. J. Pearce
Th1 and Th2 Cells Help CD8 T-Cell Responses
Infect. Immun., May 1, 2007; 75(5): 2291 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. Krawczyk, H. Shen, and E. J. Pearce
Functional Plasticity in Memory T Helper Cell Responses
J. Immunol., April 1, 2007; 178(7): 4080 - 4088.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Haase, M. Ejrnaes, A. E. Juedes, T. Wolfe, H. Markholst, and M. G. von Herrath
Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo
Blood, December 15, 2005; 106(13): 4225 - 4233.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Artis, C. M. Kane, J. Fiore, C. Zaph, S. Shapira, K. Joyce, A. MacDonald, C. Hunter, P. Scott, and E. J. Pearce
Dendritic Cell-Intrinsic Expression of NF-{kappa}B1 Is Required to Promote Optimal Th2 Cell Differentiation
J. Immunol., June 1, 2005; 174(11): 7154 - 7159.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Liu, Q. Liu, H. Hamed, R. M. Anthony, A. Foster, F. D. Finkelman, J. F. Urban Jr, and W. C. Gause
IL-2 and Autocrine IL-4 Drive the In Vivo Development of Antigen-Specific Th2 T Cells Elicited by Nematode Parasites
J. Immunol., February 15, 2005; 174(4): 2242 - 2249.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Sun, M. Walsh, A. V. Villarino, L. Cervi, C. A. Hunter, Y. Choi, and E. J. Pearce
TLR Ligands Can Activate Dendritic Cells to Provide a MyD88-Dependent Negative Signal for Th2 Cell Development
J. Immunol., January 15, 2005; 174(2): 742 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
L. de Repentigny, D. Lewandowski, and P. Jolicoeur
Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection
Clin. Microbiol. Rev., October 1, 2004; 17(4): 729 - 759.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Jankovic, M. C. Kullberg, P. Caspar, and A. Sher
Parasite-Induced Th2 Polarization Is Associated with Down-Regulated Dendritic Cell Responsiveness to Th1 Stimuli and a Transient Delay in T Lymphocyte Cycling
J. Immunol., August 15, 2004; 173(4): 2419 - 2427.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Terme, E. Tomasello, K. Maruyama, F. Crepineau, N. Chaput, C. Flament, J.-P. Marolleau, E. Angevin, E. F. Wagner, B. Salomon, et al.
IL-4 Confers NK Stimulatory Capacity to Murine Dendritic Cells: A Signaling Pathway Involving KARAP/DAP12-Triggering Receptor Expressed on Myeloid Cell 2 Molecules
J. Immunol., May 15, 2004; 172(10): 5957 - 5966.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. R. Ramirez-Pineda, A. Frohlich, C. Berberich, and H. Moll
Dendritic Cells (DC) Activated by CpG DNA Ex Vivo Are Potent Inducers of Host Resistance to an Intracellular Pathogen That Is Independent of IL-12 Derived from the Immunizing DC
J. Immunol., May 15, 2004; 172(10): 6281 - 6289.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Cervi, A. S. MacDonald, C. Kane, F. Dzierszinski, and E. J. Pearce
Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses
J. Immunol., February 15, 2004; 172(4): 2016 - 2020.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. A. Jones, M. Fernandez, K. Herc, L. Bosnjak, M. Miranda-Saksena, R. A. Boadle, and A. Cunningham
Herpes Simplex Virus Type 2 Induces Rapid Cell Death and Functional Impairment of Murine Dendritic Cells In Vitro
J. Virol., October 15, 2003; 77(20): 11139 - 11149.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
Y.-T. A. Teng
THE ROLE OF ACQUIRED IMMUNITY AND PERIODONTAL DISEASE PROGRESSION
Critical Reviews in Oral Biology & Medicine, July 1, 2003; 14(4): 237 - 252.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. Tschoep, T. C. Manning, H. Harlin, C. George, M. Johnson, and T. F. Gajewski
Disparate functions of immature and mature human myeloid dendritic cells: implications for dendritic cell-based vaccines
J. Leukoc. Biol., July 1, 2003; 74(1): 69 - 80.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Berberich, J. R. Ramirez-Pineda, C. Hambrecht, G. Alber, Y. A. W. Skeiky, and H. Moll
Dendritic Cell (DC)-Based Protection Against an Intracellular Pathogen Is Dependent Upon DC-Derived IL-12 and Can Be Induced by Molecularly Defined Antigens
J. Immunol., March 15, 2003; 170(6): 3171 - 3179.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. D. Straw, A. S. MacDonald, E. Y. Denkers, and E. J. Pearce
CD154 Plays a Central Role in Regulating Dendritic Cell Activation During Infections That Induce Th1 or Th2 Responses
J. Immunol., January 15, 2003; 170(2): 727 - 734.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y.-T. A. Teng
Mixed Periodontal Th1-Th2 Cytokine Profile in Actinobacillus actinomycetemcomitans-Specific Osteoprotegerin Ligand (or RANK-L)- Mediated Alveolar Bone Destruction In Vivo
Infect. Immun., September 1, 2002; 70(9): 5269 - 5273.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.