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-Chain1
*
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814;
Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910; and
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892
Elf-1, a member of the E 26-specific transcription factor family
with a predicted molecular mass of 68 kDa, is involved in the
transcriptional regulation of several hematopoietic cell genes. We
demonstrate that Elf-1 exists primarily as a 98-kDa form in the nucleus
and as an 80-kDa form in the cytoplasm. Phosphorylation and
O-linked glycosylation contribute to the increased
posttranslational molecular mass of Elf-1. The 98-kDa Elf-1 is released
from the cytoplasm tethering retinoblastoma protein and moves to the
nucleus, where it binds to the promoter of the TCR 
-chain gene.
Finally, the cytoplasmic 98-kDa form enters the proteasome pathway and
undergoes degradation. In conclusion, different forms of Elf-1 are the
products of posttranslational modifications that determine its
subcellular localization, activity, and metabolic
degradation.
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