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*
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, and
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
CCR9 mediates chemotaxis in response to CCL25/thymus-expressed
chemokine and is selectively expressed on T cells in the thymus and
small intestine. To investigate the role of CCR9 in T cell development,
the CCR9 gene was disrupted by homologous recombination. B cell
development, thymic 
-T cell development, and thymocyte selection
appeared unimpaired in adult CCR9-deficient (CCR9-/-)
mice. However, competitive transplantation experiments revealed that
bone marrow from CCR9-/- mice was less efficient at
repopulating the thymus of lethally irradiated Rag-1-/-
mice than bone marrow from littermate CCR9+/+ mice.
CCR9-/- mice had increased numbers of peripheral 
-T
cells but reduced numbers of TCR+ and
CD8+TCR+ intraepithelial
lymphocytes in the small intestine. Thus, CCR9 plays an important,
although not indispensable, role in regulating the development and/or
migration of both - and - T
lymphocytes.
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